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Submissions

solute carrier family 1 member 2

Summary

Gene Symbol

SLC1A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6506

KEGG Gene ID

PubChem

6506

Alliance of Genome Resources

HGNC:10940

Annotation

Keyword

3D-structure
Alternative splicing
Amino-acid transport
Cell membrane
Chloride
Disease variant
Epilepsy
Glycoprotein
Metal-binding
Palmitate
Phosphoprotein
Potassium
Proteomics identification
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying **all 5** entries
UniProt	Protein Name
A0A2R8Y860
A0A2U3TZS7
A2A2U1
P43004	Glutamate/aspartate transporter II Sodium-dependent glutamate/aspartate transporter 2 Solute carrier family 1 member 2
A0A2R8YFE3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 34 in total

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GO Term	Evidence Code	PMID
glutathione biosynthetic process	IEA
neurotransmitter transport	TAS
neurotransmitter transport	IEA
amino acid transport	TAS
chemical synaptic transmission	TAS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

metabolic process [inference]

peptide metabolic process [inference]

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

modified amino acid metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound metabolic process [inference]

glutathione metabolic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

biosynthetic process [inference]

modified amino acid biosynthetic process [inference]

glutathione biosynthetic process

peptide biosynthetic process [inference]

nonribosomal peptide biosynthetic process [inference]

glutathione biosynthetic process

sulfur compound biosynthetic process [inference]

glutathione biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

behavior [inference]

multicellular organism growth

developmental process [inference]

anatomical structure development [inference]

telencephalon development

growth [inference]

developmental growth [inference]

multicellular organism growth

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

chemical homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular amino acid homeostasis [inference]

intracellular glutamate homeostasis

response to stimulus [inference]

response to stress [inference]

response to wounding

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior

response to chemical [inference]

response to acid chemical [inference]

response to amino acid

response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

response to nitrogen compound [inference]

response to alkaloid [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

response to oxygen-containing compound [inference]

response to cocaine [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to cocaine

cellular response to oxygen-containing compound [inference]

cellular response to cocaine

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic anion transport [inference]

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

neurotransmitter transport

neurotransmitter uptake [inference]

neurotransmitter reuptake

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

acidic amino acid transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

neutral amino acid transport

cysteine transport [inference]

cysteine transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

vascular transport [inference]

transport across blood-brain barrier

organic cation transport [inference]

cysteine transport [inference]

cysteine transmembrane transport

organic anion transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport [inference]

cysteine transmembrane transport

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

cysteine transport [inference]

cysteine transmembrane transport

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic anion transmembrane transport

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

carboxylic acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

cysteine transmembrane transport

transepithelial transport

nitrogen compound transport [inference]

sulfur amino acid transport [inference]

cysteine transport [inference]

cysteine transmembrane transport

L-amino acid transport [inference]

L-glutamate import [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-alpha-amino acid transmembrane transport [inference]

L-glutamate transmembrane transport

L-glutamate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

aspartate transmembrane transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

L-aspartate transmembrane transport

L-aspartate import across plasma membrane

D-amino acid transport [inference]

D-aspartate transmembrane transport [inference]

D-aspartate import across plasma membrane

sulfur compound transport [inference]

sulfur amino acid transport [inference]

cysteine transport [inference]

cysteine transmembrane transport

import into cell

neurotransmitter uptake [inference]

neurotransmitter reuptake

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

establishment of localization in cell [inference]

neurotransmitter reuptake

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transport [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of cellular process [inference]

regulation of transmembrane transport [inference]

regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

regulation of D-glucose import across plasma membrane [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

positive regulation of cellular process [inference]

positive regulation of transmembrane transport [inference]

positive regulation of D-glucose transmembrane transport [inference]

positive regulation of D-glucose import across plasma membrane

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IMP
plasma membrane	IBA
plasma membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

cell projection membrane [inference]

neuron projection membrane [inference]

axolemma

synaptic membrane [inference]

presynaptic membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

glutamatergic synapse

leading edge membrane [inference]

neuron projection membrane [inference]

axolemma

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

glial cell projection [inference]

astrocyte projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
L-glutamate transmembrane transporter activity	TAS
L-glutamate transmembrane transporter activity	IDA
L-glutamate transmembrane transporter activity	IBA
L-glutamate transmembrane transporter activity	IEA
high-affinity L-glutamate transmembrane transporter activity	TAS

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

monoatomic anion transmembrane transporter activity

amino acid transmembrane transporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity

solute:monoatomic cation symporter activity [inference]

amino acid:monoatomic cation symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

solute:sodium symporter activity [inference]

amino acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

organic acid:sodium symporter activity [inference]

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

carboxylic acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

L-amino acid transmembrane transporter activity

L-glutamate transmembrane transporter activity

high-affinity L-glutamate transmembrane transporter activity

glutamate:sodium symporter activity

high-affinity L-glutamate transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

cysteine transmembrane transporter activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080442	developmental and epileptic encephalopathy 41	Alliance of Genome Resources

Ortholog

Displaying **all 5** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20511	MGI:101931
Rattus norvegicus	29482	RGD:3697
Caenorhabditis elegans	177882	WB:WBGene00001621
Caenorhabditis elegans	187623	WB:WBGene00001624
Caenorhabditis elegans	180641	WB:WBGene00001620

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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Acknowledgements