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solute carrier family 1 member 5

Summary

Gene Symbol

SLC1A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

6510

PubChem

6510

Alliance of Genome Resources

HGNC:10943

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Alternative splicing
Amino-acid transport
Antiport
Cell membrane
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Metal-binding
Phosphoprotein
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q15758	Baboon M7 virus receptor RD114/simian type D retrovirus receptor Sodium-dependent neutral amino acid transporter type 2 Solute carrier family 1 member 5
Q59ES3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
L-aspartate import across plasma membrane	IBA
transport across blood-brain barrier	ISS
transport across blood-brain barrier	NAS	26590417 30280653
L-glutamine import across plasma membrane	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

export from cell [inference]

secretion by cell [inference]

glutamine secretion

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

secretion [inference]

secretion by cell [inference]

glutamine secretion

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

nitrogen compound transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

import into cell [inference]

amino acid import across plasma membrane [inference]

export from cell [inference]

secretion by cell [inference]

glutamine secretion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	23492904 24953180
plasma membrane	IBA
basal plasma membrane	ISS
membrane	IDA	29872227

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

membrane

plasma membrane

plasma membrane region [inference]

basal plasma membrane

centriolar satellite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
L-aspartate transmembrane transporter activity	ISS
L-aspartate transmembrane transporter activity	IBA
L-glutamine transmembrane transporter activity	TAS	21757002
L-glutamine transmembrane transporter activity	IDA	29872227
L-serine transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-amino acid transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-amino acid transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

binding [inference]

protein binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Ortholog

Displaying entries **51 - 60** of 76 in total

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Species	Gene ID	Orthologous MAtrix
Nannospalax galili	103724657	NANGA21282
Rhinopithecus roxellana	104673399	RHIRO06812
Macaca nemestrina	105478592	MACNE39648
Mandrillus leucophaeus	105531675	MANLE26203
Cercocebus atys	105595193	CERAT28402
Aotus nancymaae	105713015	AOTNA29117
Propithecus coquereli	105817644	PROCO06231
Salmo salar	106612393	SALSA141454
Equus asinus asinus	106845166	EQUAS26543
Sinocyclocheilus grahami	107566078	SINGR91238

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Acknowledgements