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solute carrier family 1 member 5

Summary

Gene Symbol

SLC1A5

Organism

Homo sapiens (human)

External Links

NCBI Gene

6510

PubChem

6510

Alliance of Genome Resources

HGNC:10943

Annotation

Keyword

3D-structure
Acetylation
Alternative initiation
Alternative splicing
Amino-acid transport
Antiport
Cell membrane
Glycoprotein
Host cell receptor for virus entry
Host-virus interaction
Metal-binding
Phosphoprotein
Reference proteome
Sodium
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q15758	Baboon M7 virus receptor RD114/simian type D retrovirus receptor Sodium-dependent neutral amino acid transporter type 2 Solute carrier family 1 member 5
Q59ES3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 14** of 14 in total

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GO Term	Evidence Code	PMID
L-aspartate import across plasma membrane	IBA
transport across blood-brain barrier	ISS
transport across blood-brain barrier	NAS	26590417 30280653
L-glutamine import across plasma membrane	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein complex oligomerization [inference]

protein homooligomerization [inference]

protein homotrimerization

protein trimerization [inference]

protein homotrimerization

export from cell [inference]

secretion by cell [inference]

glutamine secretion

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

myeloid cell differentiation [inference]

erythrocyte differentiation

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

localization [inference]

establishment of localization [inference]

transport [inference]

vascular transport [inference]

transport across blood-brain barrier

secretion [inference]

secretion by cell [inference]

glutamine secretion

transmembrane transport [inference]

import across plasma membrane [inference]

amino acid import across plasma membrane [inference]

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic substance transport [inference]

organic anion transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic acid transport [inference]

carboxylic acid transport [inference]

dicarboxylic acid transport [inference]

C4-dicarboxylate transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

organic acid transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

nitrogen compound transport [inference]

amino acid transport

amino acid transmembrane transport [inference]

aspartate transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

amino acid import across plasma membrane [inference]

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

neutral amino acid transport

glutamine transport

serine transport [inference]

L-serine transport

L-amino acid transport [inference]

L-serine transport

L-alpha-amino acid transmembrane transport [inference]

L-aspartate transmembrane transport [inference]

L-aspartate import across plasma membrane

L-glutamine import across plasma membrane

import into cell [inference]

amino acid import across plasma membrane [inference]

export from cell [inference]

secretion by cell [inference]

glutamine secretion

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
plasma membrane	TAS
plasma membrane	IDA	23492904 24953180
plasma membrane	IBA
basal plasma membrane	ISS
membrane	IDA	29872227

GO Hierarchy

cellular component

cellular anatomical entity [inference]

microtubule organizing center [inference]

ciliary basal body

membrane

plasma membrane

plasma membrane region [inference]

basal plasma membrane

centriolar satellite

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
virus receptor activity	IEA
protein binding	IPI	23492904 25759021 32296183
amino acid transmembrane transporter activity	TAS
neutral L-amino acid transmembrane transporter activity	IBA
L-amino acid transmembrane transporter activity

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

organic acid transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-amino acid transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

organic anion transmembrane transporter activity [inference]

carboxylic acid transmembrane transporter activity [inference]

dicarboxylic acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

amino acid transmembrane transporter activity

acidic amino acid transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

neutral L-amino acid transmembrane transporter activity

L-glutamine transmembrane transporter activity

L-amino acid transmembrane transporter activity

C4-dicarboxylate transmembrane transporter activity [inference]

L-aspartate transmembrane transporter activity

passive transmembrane transporter activity [inference]

channel activity [inference]

gated channel activity [inference]

ligand-gated channel activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

binding [inference]

protein binding

exogenous protein binding [inference]

virus receptor activity

ion binding [inference]

cation binding [inference]

metal ion binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

amino acid transporter

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
L-alpha-amino acid transmembrane transport
L-glutamate transmembrane transporter activity
neutral L-amino acid transmembrane transporter activity
symporter activity

Displaying **all 3** entries
InterPro
Sodium
Sodium
Sodium

Ortholog

Displaying entries **11 - 20** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	25550	FB:FBgn0026439
Drosophila melanogaster	29483	FB:FBgn0026439
Drosophila melanogaster	55963	FB:FBgn0026439
Drosophila melanogaster	84012	FB:FBgn0026439
Xenopus tropicalis	188744	Xenbase:XB-GENE-482596
Drosophila melanogaster	242607	FB:FBgn0026439
Bos taurus	282355		BOVIN11380
Rattus norvegicus	292657		RATNO19050
Pan troglodytes	456155		PANTR18737
Canis lupus familiaris	484425		CANLF00894

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Acknowledgements