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solute carrier family 8 member A1

Summary

Gene Symbol

SLC8A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6546

KEGG Gene ID

PubChem

6546

Alliance of Genome Resources

HGNC:11068

Annotation

Keyword

3D-structure
Alternative splicing
Antiport
Calcium transport
Calmodulin-binding
Cell membrane
Glycoprotein
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Signal
Sodium transport
Synapse
Transmembrane helix

Proteins

Displaying **all 6** entries
UniProt	Protein Name
A0A994J4U7	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
Q4QQH3
A0A994J7E1	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
E9PB98	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
P32418	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1
A0A994J7G2	Na(+)/Ca(2+)-exchange protein 1 Solute carrier family 8 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 49 in total

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GO Term	Evidence Code	PMID
regulation of the force of heart contraction	ISS
regulation of the force of heart contraction	IC
regulation of heart rate	ISS
monoatomic ion transport	IEA
ion transport	IEA

GO Hierarchy

biological process

cellular process [inference]

cell communication

cell communication by electrical coupling [inference]

cell communication by electrical coupling involved in cardiac conduction

cell communication involved in cardiac conduction [inference]

cell communication by electrical coupling involved in cardiac conduction

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

calcium ion export across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export across plasma membrane [inference]

export from cell [inference]

export across plasma membrane [inference]

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction

smooth muscle contraction [inference]

vascular associated smooth muscle contraction

striated muscle contraction [inference]

cardiac muscle contraction

relaxation of muscle [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

developmental process [inference]

anatomical structure development [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

cellular developmental process [inference]

cell development [inference]

muscle cell development [inference]

striated muscle cell development [inference]

cardiac muscle cell development

cardiac cell development [inference]

cardiac muscle cell development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

calcium ion homeostasis

intracellular calcium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

response to external stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

response to muscle stretch

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

response to nitrogen compound [inference]

response to purine-containing compound [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to purine-containing compound [inference]

cellular response to caffeine

response to alkaloid [inference]

response to caffeine [inference]

cellular response to caffeine

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

response to oxygen-containing compound [inference]

response to reactive oxygen species [inference]

cellular response to reactive oxygen species

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to chemical stimulus [inference]

cellular response to chemical stress [inference]

cellular response to oxidative stress [inference]

cellular response to reactive oxygen species

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to caffeine

cellular response to oxygen-containing compound [inference]

cellular response to reactive oxygen species

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

sodium ion transmembrane transport

calcium ion transport

calcium ion import

calcium ion import across plasma membrane

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

calcium ion export across plasma membrane

calcium ion export

calcium ion import into cytosol [inference]

calcium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

calcium ion export across plasma membrane

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

calcium ion export across plasma membrane

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

calcium ion transmembrane transport

calcium ion transmembrane import into cytosol

calcium ion export across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export across plasma membrane [inference]

import into cell [inference]

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic cation import across plasma membrane [inference]

export from cell [inference]

export across plasma membrane [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

positive regulation of biological process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of developmental process [inference]

positive regulation of developmental process [inference]

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

calcium-mediated signaling [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of intracellular signal transduction [inference]

negative regulation of intracellular signal transduction

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of cell communication by electrical coupling

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of release of sequestered calcium ion into cytosol [inference]

regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum [inference]

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction

regulation of multicellular organismal process [inference]

regulation of ossification [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of blood circulation [inference]

regulation of heart contraction [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

regulation of heart rate

regulation of cardiac muscle contraction [inference]

regulation of cardiac muscle contraction by calcium ion signaling

regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion

regulation of cardiac conduction

positive regulation of multicellular organismal process [inference]

positive regulation of ossification [inference]

positive regulation of bone mineralization

regulation of multicellular organismal development [inference]

regulation of biomineral tissue development [inference]

regulation of bone mineralization [inference]

positive regulation of bone mineralization

positive regulation of biomineral tissue development [inference]

positive regulation of bone mineralization

regulation of biological quality [inference]

regulation of the force of heart contraction

positive regulation of the force of heart contraction

regulation of heart rate

positive regulation of cytosolic calcium ion concentration [inference]

calcium ion transport into cytosol

regulation of membrane potential [inference]

membrane depolarization [inference]

membrane depolarization during action potential [inference]

membrane depolarization during cardiac muscle cell action potential

negative regulation of cytosolic calcium ion concentration

regulation of anatomical structure size [inference]

regulation of tube size [inference]

regulation of tube diameter [inference]

blood vessel diameter maintenance [inference]

vasoconstriction [inference]

vascular associated smooth muscle contraction

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
nucleoplasm
plasma membrane	EXP
plasma membrane	TAS
plasma membrane	IDA
plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

membrane

plasma membrane

sarcolemma

Z disc

cell junction

synapse

anchoring junction [inference]

cell-cell junction [inference]

cell-cell contact zone [inference]

intercalated disc

T-tubule

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

organelle [inference]

postsynaptic specialization [inference]

postsynaptic density

cell body [inference]

neuronal cell body

neuron projection terminus [inference]

axon terminus

cell periphery

presynapse [inference]

axon terminus

postsynapse

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
calcium:sodium antiporter activity	TAS
calcium:sodium antiporter activity	IDA
calcium:sodium antiporter activity	IMP
calcium:sodium antiporter activity	IBA
calcium:sodium antiporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

calcium:sodium antiporter activity

calcium ion transmembrane transporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

calcium:monoatomic cation antiporter activity [inference]

calcium:sodium antiporter activity

binding [inference]

protein binding

calmodulin binding

cytoskeletal protein binding

ankyrin binding

transmembrane transporter binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SODIUM/CALCIUM EXCHANGER

Functional Category

E: Amino acid transport and metabolism
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
calcium ion transport
calcium
calmodulin binding
cell communication
metal ion binding
monoatomic ion transport
sodium ion transmembrane transport

Displaying **all 6** entries
InterPro
CalX-like domain superfamily
NCX, central ion-binding domain superfamily
Na-Ca exchanger/integrin-beta4
Sodium/calcium exchanger domain, C-terminal extension
Sodium/calcium exchanger membrane region
Sodium/calcium exchanger protein

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10763	hypertension	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	20541	MGI:107956
Rattus norvegicus	29715	RGD:3717
Drosophila melanogaster	42481	FB:FBgn0013995

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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OrthoDB (Group)

International Collaboration

Acknowledgements