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Guidelines

MIRAGE

solute carrier family 11 member 1

Summary

Gene Symbol

SLC11A1

Organism

Homo sapiens (human)

External Links

NCBI Gene

6556

KEGG Gene ID

PubChem

6556

Alliance of Genome Resources

HGNC:10907

Annotation

Keyword

3D-structure
Alternative splicing
Endosome
Glycoprotein
Iron transport
Lysosome
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DQ73	Solute carrier family 11 member 1
P49279	Solute carrier family 11 member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 50 in total

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GO Term	Evidence Code	PMID
inflammatory response	ISS
vacuolar acidification	ISS
response to bacterium	IDA
positive regulation of gene expression	ISS
nitrite transport	ISS

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

antigen processing and presentation [inference]

antigen processing and presentation of peptide antigen

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell proliferation [inference]

T cell proliferation involved in immune response

lymphocyte proliferation [inference]

T cell proliferation [inference]

T cell proliferation involved in immune response

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell proliferation [inference]

T cell proliferation involved in immune response

lymphocyte proliferation [inference]

T cell proliferation [inference]

T cell proliferation involved in immune response

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

MHC class II biosynthetic process

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

MHC class II biosynthetic process

respiratory burst

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation [inference]

T cell proliferation involved in immune response

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

cellular detoxification [inference]

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

leukocyte activation [inference]

myeloid leukocyte activation [inference]

macrophage activation

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell activation [inference]

T cell activation involved in immune response [inference]

T cell proliferation involved in immune response

T cell proliferation [inference]

T cell proliferation involved in immune response

lymphocyte proliferation [inference]

T cell proliferation [inference]

T cell proliferation involved in immune response

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

homeostatic process [inference]

cellular homeostasis [inference]

cell redox homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

inorganic ion homeostasis [inference]

intracellular iron ion homeostasis

manganese ion homeostasis [inference]

intracellular manganese ion homeostasis

multicellular organismal-level iron ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level iron ion homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to protozoan [inference]

defense response to protozoan

response to bacterium

defense response to bacterium

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to protozoan

defense response to symbiont [inference]

antimicrobial humoral response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to bacterium

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to protozoan

defense response to symbiont [inference]

antimicrobial humoral response

response to wounding [inference]

wound healing

immune response [inference]

humoral immune response [inference]

antimicrobial humoral response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to protozoan [inference]

defense response to protozoan

response to bacterium

defense response to bacterium

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to protozoan

defense response to symbiont [inference]

antimicrobial humoral response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to protozoan [inference]

defense response to protozoan

response to bacterium

defense response to bacterium

defense response to Gram-negative bacterium

defense response to other organism [inference]

defense response to protozoan

defense response to symbiont [inference]

antimicrobial humoral response

response to chemical [inference]

response to lipid [inference]

response to lipopolysaccharide

response to peptide [inference]

response to cytokine [inference]

response to type II interferon

response to oxygen-containing compound [inference]

response to lipopolysaccharide

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport

transition metal ion transport [inference]

iron ion transport

iron ion transmembrane transport

manganese ion transport

manganese ion transmembrane transport

cadmium ion transport [inference]

cadmium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

amino acid transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transport [inference]

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic cation transport [inference]

L-arginine transmembrane transport

inorganic anion transport [inference]

nitrite transport

organic anion transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

organic acid transport [inference]

carboxylic acid transport [inference]

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

vesicle-mediated transport [inference]

endocytosis [inference]

phagocytosis

transmembrane transport [inference]

amino acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

basic amino acid transmembrane transport [inference]

L-arginine transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

carboxylic acid transmembrane transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

nitrogen compound transport [inference]

nitrite transport

L-amino acid transport [inference]

L-alpha-amino acid transmembrane transport [inference]

L-arginine transmembrane transport

import into cell [inference]

endocytosis [inference]

phagocytosis

establishment of localization in cell

biological regulation [inference]

regulation of pH [inference]

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of antigen processing and presentation [inference]

positive regulation of antigen processing and presentation [inference]

positive regulation of dendritic cell antigen processing and presentation

regulation of dendritic cell antigen processing and presentation [inference]

positive regulation of dendritic cell antigen processing and presentation

positive regulation of immune system process [inference]

positive regulation of antigen processing and presentation [inference]

positive regulation of dendritic cell antigen processing and presentation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of antigen processing and presentation [inference]

positive regulation of dendritic cell antigen processing and presentation

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

positive regulation of transport [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of immune response [inference]

regulation of adaptive immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of T-helper 1 type immune response [inference]

positive regulation of T-helper 1 type immune response

positive regulation of immune response [inference]

positive regulation of adaptive immune response [inference]

positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [inference]

positive regulation of T-helper 1 type immune response

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

positive regulation of cytokine production

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

positive regulation of cytokine production

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of RNA metabolic process [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of mRNA stability [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of catabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA catabolic process [inference]

RNA stabilization [inference]

mRNA stabilization

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

negative regulation of mRNA metabolic process [inference]

negative regulation of mRNA catabolic process [inference]

mRNA stabilization

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis [inference]

positive regulation of phagocytosis

regulation of phagocytosis [inference]

positive regulation of phagocytosis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production

positive regulation of cytokine production

positive regulation of type II interferon production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

positive regulation of type II interferon production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production

regulation of biological quality [inference]

regulation of RNA stability [inference]

regulation of mRNA stability [inference]

mRNA stabilization

RNA stabilization [inference]

mRNA stabilization

regulation of intracellular pH [inference]

intracellular pH reduction [inference]

vacuolar acidification

detoxification [inference]

detoxification of inorganic compound [inference]

detoxification of cadmium ion [inference]

cellular detoxification of cadmium ion

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

cellular detoxification [inference]

cellular detoxification of metal ion [inference]

cellular detoxification of cadmium ion

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
lysosome	ISS
lysosome	IEA
lysosomal membrane	ISS
lysosomal membrane	IBA
lysosomal membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

late endosome membrane

endocytic vesicle membrane [inference]

phagocytic vesicle membrane

secretory granule membrane [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
iron ion transmembrane transporter activity	IDA
iron ion transmembrane transporter activity	IBA
iron ion transmembrane transporter activity	IEA
manganese ion transmembrane transporter activity	ISS
manganese ion transmembrane transporter activity	IDA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

metal cation:proton antiporter activity

metal ion transmembrane transporter activity

transition metal ion transmembrane transporter activity

metal cation:monoatomic cation antiporter activity [inference]

metal cation:proton antiporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

antiporter activity [inference]

metal cation:monoatomic cation antiporter activity [inference]

metal cation:proton antiporter activity

binding [inference]

protein binding [inference]

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

transporter

Functional Category

K: Transcription
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
cadmium ion transmembrane transporter activity
manganese ion transmembrane transporter activity
metal ion transmembrane transporter activity

Displaying 1 entry
InterPro
NRAMP family

Disease

Disease Ontology

Displaying entries **1 - 10** of 19 in total

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DO ID	Disease Name	Source
DOID:2377	multiple sclerosis	Alliance of Genome Resources
DOID:9146	visceral leishmaniasis	Alliance of Genome Resources
DOID:11335	sarcoidosis	Alliance of Genome Resources
DOID:7148	rheumatoid arthritis	Alliance of Genome Resources
DOID:0060704	lymphoproliferative syndrome	Alliance of Genome Resources
DOID:418	systemic scleroderma	Alliance of Genome Resources
DOID:1024	leprosy	Alliance of Genome Resources
DOID:676	systemic juvenile rheumatoid arthritis	Alliance of Genome Resources
DOID:9111	cutaneous leishmaniasis	Alliance of Genome Resources
DOID:13241	Behcet's disease	Alliance of Genome Resources

Ortholog

Displaying **all 7** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	18173	MGI:1345275
Rattus norvegicus	316519	RGD:1601463
Caenorhabditis elegans	180939	WB:WBGene00004876
Caenorhabditis elegans	191766	WB:WBGene00004877
Caenorhabditis elegans	177044	WB:WBGene00004878
Drosophila melanogaster	42490	FB:FBgn0011672
Saccharomyces cerevisiae S288C	850721	SGD:S000004024

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Last updated: April 6, 2026