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solute carrier family 12 member 2

Summary

Gene Symbol

SLC12A2

Organism

Homo sapiens (human)

External Links

NCBI Gene

6558

PubChem

6558

Alliance of Genome Resources

HGNC:10911

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cell membrane
Chloride
Disease variant
Disulfide bond
Intellectual disability
Non-syndromic deafness
Phosphoprotein
Potassium transport
Reference proteome
Sodium transport
Symport
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q53ZR1
P55011	Basolateral Na-K-Cl symporter Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
B7ZM24

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 38 in total

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GO Term	Evidence Code	PMID
sodium ion transmembrane transport	IBA
cellular response to potassium ion	ISS
positive regulation of cell volume	IEA
chloride ion homeostasis	IBA
potassium ion homeostasis	IBA

GO Hierarchy

biological process

immune system process [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

T cell migration [inference]

T cell chemotaxis

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

mononuclear cell migration [inference]

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

T cell migration [inference]

T cell chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to salt [inference]

cellular response to potassium ion

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

positive regulation of cell volume

multicellular organismal process [inference]

system process [inference]

circulatory system process [inference]

vascular process in circulatory system [inference]

vascular transport [inference]

transport across blood-brain barrier

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

lymphocyte chemotaxis [inference]

T cell chemotaxis

homeostatic process [inference]

cellular homeostasis [inference]

cell volume homeostasis

positive regulation of cell volume

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

multicellular organismal-level homeostasis [inference]

anatomical structure homeostasis [inference]

tissue homeostasis [inference]

maintenance of blood-brain barrier

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

potassium ion homeostasis

intracellular potassium ion homeostasis

sodium ion homeostasis

intracellular sodium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

inorganic ion homeostasis [inference]

chloride ion homeostasis

intracellular chloride ion homeostasis

potassium ion homeostasis

intracellular potassium ion homeostasis

sodium ion homeostasis

intracellular sodium ion homeostasis

response to stimulus [inference]

response to stress [inference]

response to osmotic stress [inference]

hyperosmotic response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

response to chemokine [inference]

cellular response to chemokine

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

response to inorganic substance [inference]

response to metal ion [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to salt [inference]

cellular response to potassium ion

response to oxygen-containing compound [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

response to salt [inference]

response to potassium ion [inference]

cellular response to potassium ion

cellular response to salt [inference]

cellular response to potassium ion

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to potassium ion

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to chemokine

cellular response to oxygen-containing compound [inference]

cellular response to potassium ion

cellular response to salt [inference]

cellular response to potassium ion

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport

monoatomic cation transport [inference]

metal ion transport [inference]

potassium ion transport [inference]

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

sodium ion transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transport [inference]

chloride transport [inference]

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

vascular transport [inference]

transport across blood-brain barrier

inorganic anion transport [inference]

chloride transport [inference]

inorganic anion transmembrane transport [inference]

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

monoatomic anion transmembrane transport [inference]

chloride transmembrane transport

inorganic ion transmembrane transport [inference]

inorganic anion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

sodium ion transmembrane transport

sodium ion import across plasma membrane

potassium ion transmembrane transport [inference]

potassium ion import across plasma membrane

ammonium transmembrane transport

inorganic cation import across plasma membrane

inorganic ion import across plasma membrane [inference]

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

import across plasma membrane [inference]

inorganic ion import across plasma membrane [inference]

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

transepithelial transport [inference]

nitrogen compound transport [inference]

import into cell [inference]

inorganic ion import across plasma membrane [inference]

inorganic anion import across plasma membrane

inorganic cation import across plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of spontaneous synaptic transmission

signaling [inference]

cell-cell signaling [inference]

gamma-aminobutyric acid signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of organic acid transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of secretion [inference]

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of amine transport [inference]

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of amino acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

positive regulation of transport [inference]

positive regulation of organic acid transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

positive regulation of secretion [inference]

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

positive regulation of amine transport [inference]

positive regulation of amino acid transport [inference]

positive regulation of aspartate secretion

negative regulation of biological process [inference]

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of response to stimulus [inference]

regulation of response to external stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

negative regulation of response to stimulus [inference]

negative regulation of response to external stimulus [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

negative regulation of response to wounding [inference]

negative regulation of wound healing [inference]

negative regulation of vascular wound healing

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

negative regulation of developmental process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of spontaneous synaptic transmission

positive regulation of cellular process [inference]

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

regulation of cellular localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

regulation of secretion by cell [inference]

regulation of protein secretion [inference]

regulation of matrix metallopeptidase secretion

positive regulation of secretion by cell [inference]

positive regulation of aspartate secretion

regulation of aspartate secretion [inference]

positive regulation of aspartate secretion

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of vascular wound healing [inference]

negative regulation of vascular wound healing

negative regulation of vasculature development [inference]

negative regulation of blood vessel morphogenesis [inference]

negative regulation of angiogenesis [inference]

negative regulation of vascular wound healing

regulation of biological quality [inference]

regulation of anatomical structure size [inference]

regulation of cellular component size [inference]

regulation of cell size [inference]

cell volume homeostasis

positive regulation of cell volume

Displaying entries **16 - 20** of 20 in total

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GO Term	Evidence Code	PMID
cell body membrane	TAS	11940529
extracellular exosome	HDA	19199708 20458337
cell periphery	ISS	15347682
cell periphery	IDA	16227993
extracellular vesicle	HDA	24769233

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane

plasma membrane region [inference]

lateral plasma membrane

cell projection

plasma membrane bounded cell projection [inference]

neuron projection

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle

extracellular exosome

cell body

neuronal cell body

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	17721439 22570591 24555568
sodium:potassium:chloride symporter activity	TAS
sodium:potassium:chloride symporter activity	IDA	33597714
sodium:potassium:chloride symporter activity	IBA
ammonium transmembrane transporter activity	IDA	12946942 18032481