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Guidelines

MIRAGE

cubilin

Summary

Gene Symbol

Cubn

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

65969

PubChem

65969

Alliance of Genome Resources

MGI:1931256

Annotation

Keyword

Calcium
Cell membrane
Cholesterol metabolism
Cleavage on pair of basic residues
Coated pit
Cobalamin
Direct protein sequencing
Disulfide bond
EGF-like domain
Endosome
Glycoprotein
Lysosome
Metal-binding
Phosphoprotein
Protein transport
Reference proteome
Repeat
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9JLB4	Intrinsic factor-cobalamin receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **11 - 13** of 13 in total

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GO Term	Evidence Code	PMID
lipoprotein transport	IDA	15616221
establishment of localization in cell	IDA	15616221
establishment of localization in cell	IMP	15616221

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

catabolic process [inference]

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

vitamin metabolic process [inference]

water-soluble vitamin metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

small molecule catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

sterol metabolic process [inference]

cholesterol metabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic substance catabolic process [inference]

organic cyclic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organonitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

secondary alcohol metabolic process [inference]

cholesterol metabolic process

sterol metabolic process [inference]

cholesterol metabolic process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular catabolic process [inference]

vitamin catabolic process [inference]

water-soluble vitamin catabolic process [inference]

cobalamin catabolic process

aromatic compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular nitrogen compound catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle metabolic process [inference]

tetrapyrrole metabolic process [inference]

cobalamin metabolic process

cobalamin catabolic process

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

heterocycle catabolic process [inference]

tetrapyrrole catabolic process [inference]

cobalamin catabolic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

response to stimulus [inference]

response to external stimulus [inference]

response to extracellular stimulus [inference]

response to nutrient levels [inference]

response to nutrient

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

response to chemical [inference]

response to nutrient

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

vitamin transport [inference]

cobalamin transport

organic substance transport [inference]

protein transport [inference]

cobalamin transport

nitrogen compound transport [inference]

protein transport [inference]

cobalamin transport

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis

endocytic hemoglobin import into cell

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

establishment of localization in cell

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

lipoprotein localization [inference]

lipoprotein transport

establishment of protein localization [inference]

protein transport [inference]

establishment of protein localization to organelle [inference]

endocytic hemoglobin import into cell

Displaying entries **1 - 5** of 28 in total

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GO Term	Evidence Code	PMID
cytoplasm	IDA	11856751
lysosomal membrane	IEA
endosome	IDA	10766831 12815097
endoplasmic reticulum	IDA	15616221
Golgi apparatus	IDA	15616221

GO Hierarchy

cellular component

protein-containing complex

receptor complex

cellular anatomical entity [inference]

cytoplasm

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endocytic vesicle membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endocytic vesicle membrane

plasma membrane region [inference]

cell projection membrane [inference]

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

vacuolar lumen [inference]

lysosomal lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

apical part of cell

cluster of actin-based cell projections [inference]

brush border

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI	11856751
hemoglobin binding	ISO
cobalamin binding	IEA
signaling receptor activity	TAS	10766831

GO Hierarchy

molecular function

binding [inference]

protein binding

hemoglobin binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

cobalamin binding

heterocyclic compound binding [inference]

cobalamin binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

cobalamin binding

cargo receptor activity

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Cubilin

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
calcium ion binding

Displaying **all 7** entries
InterPro
CUB domain
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-type aspartate/asparagine hydroxylation site
NOTCH1 EGF-like calcium-binding domain
Spermadhesin, CUB domain superfamily

Ortholog

Displaying entries **1 - 10** of 80 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	8029	Xenbase:XB-GENE-957007	HUMAN00415
Xenopus tropicalis	65969	Xenbase:XB-GENE-957007
Rattus norvegicus	80848	Xenbase:XB-GENE-957007	RATNO12306
Xenopus tropicalis	179729	Xenbase:XB-GENE-957007
Xenopus tropicalis	326235	Xenbase:XB-GENE-957007
Canis lupus familiaris	403767		CANLF06533
Pan troglodytes	450327		PANTR00240
Bos taurus	523202		BOVIN04467
Macaca mulatta	705162		MACMU44856
Monodelphis domestica	100026923		MONDO34213

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Supported by JST NBDC Grant Number JPMJND2204

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Last updated: December 8, 2025