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MIRAGE

ADAM metallopeptidase with thrombospondin type 1 motif, 4

Summary

Gene Symbol

Adamts4

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

66015

PubChem

66015

Alliance of Genome Resources

RGD:621242

Annotation

Keyword

Cleavage on pair of basic residues
Disulfide bond
Extracellular matrix
Glycoprotein
Metal-binding
Metalloprotease
Reference proteome
Zinc
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ESP7	Aggrecanase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
proteolysis	ISO
proteolysis	IBA
proteolysis	IEA
extracellular matrix organization	IBA
extracellular matrix organization	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization

external encapsulating structure organization [inference]

extracellular matrix organization

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to bacterium

Displaying **all 5** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IEA
nuclear speck	ISO
nuclear speck	IEA
extracellular matrix	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

nuclear body [inference]

nuclear speck

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
protease binding	ISO
protease binding	IEA
metalloendopeptidase activity	ISO
metalloendopeptidase activity	IBA
metalloendopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity [inference]

metalloendopeptidase activity

metallopeptidase activity

metalloendopeptidase activity

binding [inference]

protein binding [inference]

enzyme binding [inference]

protease binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

A disintegrin and metalloproteinase with thrombospondin motifs

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
extracellular matrix organization
metalloendopeptidase activity
metallopeptidase activity
proteolysis

Displaying **all 2** entries
InterPro
Metallopeptidase, catalytic domain superfamily
Peptidase M12B, ADAM/reprolysin

Ortholog

Displaying entries **31 - 40** of 67 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Otolemur garnettii	100949534		OTOGA15529
Pan paniscus	100978654		PANPA02942
Papio anubis	101001940		PAPAN18477
Saimiri boliviensis boliviensis	101049525		SAIBB29368
Felis catus	101089488		FELCA36365
Ovis aries	101106565		SHEEP01082
Gorilla gorilla gorilla	101151733		GORGO20735
Octodon degus	101580274		OCTDE18132
Jaculus jaculus	101615695		JACJA23383
Mustela putorius furo	101674803		MUSPF03445

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025