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ST14 transmembrane serine protease matriptase

Summary

Gene Symbol

ST14

Organism

Homo sapiens (human)

External Links

NCBI Gene

6768

KEGG Gene ID

PubChem

6768

Alliance of Genome Resources

HGNC:11344

Annotation

Keyword

3D-structure
Disease variant
Disulfide bond
Glycoprotein
Hypotrichosis
Ichthyosis
Proteomics identification
Reference proteome
Repeat
Serine protease
Signal-anchor
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y5Y6	Matriptase Membrane-type serine protease 1 Prostamin Serine protease 14 Serine protease TADG-15 Tumor-associated differentially-expressed gene 15 protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
neural tube closure
proteolysis	TAS
proteolysis	IDA
proteolysis	IEA
protein processing	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process

protein metabolic process [inference]

proteolysis

protein processing

protein catabolic process

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

protein catabolic process

protein maturation [inference]

protein processing

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

developmental process [inference]

anatomical structure morphogenesis [inference]

cell morphogenesis [inference]

epithelial cell morphogenesis [inference]

epithelial cell morphogenesis involved in placental branching

embryonic morphogenesis [inference]

epithelial cell morphogenesis involved in placental branching

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

animal organ development

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

epidermal cell differentiation [inference]

keratinocyte differentiation

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GO Term	Evidence Code	PMID
extracellular region	IEA
obsolete extracellular space
plasma membrane	TAS
plasma membrane	IBA
external side of plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

extracellular region

membrane

plasma membrane

plasma membrane region [inference]

basolateral plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying **all 5** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA
serine-type peptidase activity	TAS
serine-type peptidase activity	IDA
serine-type peptidase activity	IBA
serine-type peptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

of tumorigenicity 14

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
acrosome reaction
hydrolase activity
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

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InterPro
CUB domain
LDL receptor-like superfamily
Low-density lipoprotein (LDL) receptor class A repeat
Low-density lipoprotein (LDL) receptor class A, conserved site
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, matripase
SEA domain superfamily
SEA domain
Serine proteases, trypsin domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060720	autosomal recessive congenital ichthyosis 11	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	19143	MGI:1338881
Drosophila melanogaster	41958	FB:FBgn0003319

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements