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poly-U binding splicing factor 60

Summary

Gene Symbol

Puf60

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

67959

PubChem

67959

Alliance of Genome Resources

MGI:1915209

Annotation

Keyword

Acetylation
Alternative splicing
Apoptosis
DNA-binding
Isopeptide bond
Nucleus
Phosphoprotein
RNA-binding
Reference proteome
Repeat
Repressor
Ribonucleoprotein
Transcription regulation
Ubl conjugation
mRNA splicing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q3UEB3	60 kDa poly(U)-binding-splicing factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
alternative mRNA splicing, via spliceosome	IBA
regulation of alternative mRNA splicing, via spliceosome	IBA
regulation of alternative mRNA splicing, via spliceosome	IEA
mRNA splice site recognition	IBA
mRNA processing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

cellular process [inference]

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

RNA splicing

RNA splicing, via transesterification reactions [inference]

RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [inference]

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

mRNA metabolic process [inference]

mRNA processing

mRNA splicing, via spliceosome [inference]

alternative mRNA splicing, via spliceosome

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

protein-RNA complex organization [inference]

protein-RNA complex assembly [inference]

mRNA splice site recognition

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of mRNA metabolic process [inference]

regulation of mRNA processing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of RNA splicing [inference]

regulation of mRNA splicing, via spliceosome [inference]

regulation of alternative mRNA splicing, via spliceosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	ISO
nucleoplasm	IEA
cell junction	ISO
cell junction	IEA
ribonucleoprotein complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

ribonucleoprotein complex

cellular anatomical entity [inference]

Displaying **all 4** entries
GO Term	Evidence Code	PMID
DNA binding	IEA
RNA binding	IEA
identical protein binding	ISO
identical protein binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

identical protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

poly(u)-binding-splicing factor puf60

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
alternative mRNA splicing, via spliceosome
mRNA splice site recognition
regulation of alternative mRNA splicing, via spliceosome

Displaying **all 5** entries
InterPro
Nucleotide-binding alpha-beta plait domain superfamily
PUF60, RNA recognition motif 1
RNA recognition motif domain, eukaryote
RNA recognition motif domain
RNA-binding domain superfamily

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	22827	Xenbase:XB-GENE-5785623	HUMAN95966
Xenopus tropicalis	67959	Xenbase:XB-GENE-5785623
Rattus norvegicus	84401		RATNO39666
Bos taurus	512824		BOVIN05580
Canis lupus familiaris	607245		CANLF03285
Macaca mulatta	699008		MACMU44121
Monodelphis domestica	100017015		MONDO18957
Equus caballus	100065550		HORSE43047
Pongo abelii	100174042		PONAB34959
Pongo abelii	100189623		PONAB34959

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OrthoDB (Group)

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Acknowledgements