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integrator complex subunit 1

Summary

Gene Symbol

Ints1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

68510

KEGG Gene ID

PubChem

68510

Alliance of Genome Resources

MGI:1915760

Annotation

Keyword

Acetylation
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q3U1N8
Q6P4S8
A0A0G2JH17

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
blastocyst growth	IMP
inner cell mass cell proliferation	IMP
embryo implantation	IMP
snRNA processing	ISO
regulation of transcription elongation by RNA polymerase II	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

catabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound catabolic process [inference]

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

snRNA metabolic process [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

nucleic acid catabolic process [inference]

RNA catabolic process [inference]

RNA surveillance [inference]

nuclear RNA surveillance [inference]

RNA polymerase II transcription initiation surveillance

RNA processing [inference]

snRNA processing

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

RNA 3'-end processing [inference]

snRNA 3'-end processing [inference]

U2 snRNA 3'-end processing

cell population proliferation [inference]

inner cell mass cell proliferation

reproductive process [inference]

embryo implantation

growth [inference]

developmental growth [inference]

blastocyst growth

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of DNA-templated transcription elongation [inference]

regulation of transcription elongation by RNA polymerase II

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleus	ISO
nucleus	IDA
nucleus	IEA
nuclear membrane	ISS
nuclear membrane	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying 1 entry
GO Term	Evidence Code	PMID
molecular_function	ND

GO Hierarchy

molecular function

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Integrator complex subunit

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism

Displaying 1 entry
Gene Ontology
U2 snRNA 3'-end processing

Displaying **all 3** entries
InterPro
Armadillo-type fold
Integrator complex subunit 1, RPB2-binding domain
Integrator complex subunit 1

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	26173	HGNC:24555

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Last updated: April 6, 2026

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Acknowledgements