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complement component 8, gamma polypeptide

Summary

Gene Symbol

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

69379

KEGG Gene ID

PubChem

69379

Alliance of Genome Resources

MGI:88237

Annotation

Keyword

Complement alternate pathway
Disulfide bond
Glycoprotein
Membrane attack complex
Proteomics identification
Pyrrolidone carboxylic acid
Reference proteome
Retinol-binding
Secreted
Signal
Target cell membrane

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q8VCG4
Q9DAC2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
complement activation	ISS
complement activation	ISO
complement activation	IEA
complement activation, alternative pathway
complement activation, classical pathway

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

activation of immune response [inference]

complement activation

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

cellular process [inference]

cell killing [inference]

killing of cells of another organism

transmembrane transport

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

immune response [inference]

humoral immune response [inference]

complement activation

innate immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

localization [inference]

establishment of localization [inference]

transport [inference]

transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

regulation of immune response [inference]

positive regulation of immune response

activation of immune response [inference]

complement activation

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular region	ISS
extracellular region	ISO
extracellular region	IEA
membrane attack complex	ISO
membrane attack complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

pore complex [inference]

membrane attack complex

plasma membrane protein complex [inference]

membrane attack complex

transmembrane transporter complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical structure [inference]

extracellular region

membrane [inference]

plasma membrane

other organism part [inference]

other organism cell membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
retinol binding
wide pore channel activity	ISO
wide pore channel activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

passive transmembrane transporter activity [inference]

channel activity [inference]

wide pore channel activity

binding [inference]

lipid binding [inference]

isoprenoid binding [inference]

retinoid binding [inference]

retinol binding

small molecule binding [inference]

vitamin binding [inference]

retinol binding

alcohol binding [inference]

retinol binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement component c8 gamma chain

Functional Category

K: Transcription
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
complement activation
complement binding

Displaying **all 4** entries
InterPro
Alpha-1-microglobulin
Calycin
Complement component C8 gamma chain
Lipocalin/cytosolic fatty-acid binding domain

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

GlyCosmos Portal v4.5.0

Last updated: April 6, 2026

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Acknowledgements