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N-acylethanolamine acid amidase

Summary

Gene Symbol

NAAA

Organism

Macaca mulatta (Rhesus monkey)

External Links

NCBI Gene: 700991
KEGG Gene ID: mcc:700991
PubChem: 700991

Annotation

Keyword

Autocatalytic cleavage
Fatty acid metabolism
Glycoprotein
Hydrolase
Lipid degradation
Lysosome
Membrane
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
I0FLL8	Acylsphingosine deacylase NAAA

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
fatty acid metabolic process	IEA	22301074
sphingosine metabolic process
N-acylethanolamine metabolic process
N-acylphosphatidylethanolamine metabolic process

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

organic substance metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

amine metabolic process [inference]

biogenic amine metabolic process [inference]

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

N-acylphosphatidylethanolamine metabolic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

polyol metabolic process [inference]

diol metabolic process [inference]

sphingosine metabolic process

primary alcohol metabolic process [inference]

N-acylethanolamine metabolic process

ethanolamine-containing compound metabolic process [inference]

N-acylethanolamine metabolic process

cellular process [inference]

cellular metabolic process [inference]

organic acid metabolic process [inference]

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

fatty acid metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

cellular lipid metabolic process [inference]

fatty acid metabolic process

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingoid metabolic process [inference]

sphingosine metabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylethanolamine metabolic process [inference]

N-acylphosphatidylethanolamine metabolic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lysosome	IEA	22301074
membrane

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
N-acylsphingosine amidohydrolase activity
fatty acid amide hydrolase activity	IEA	22301074
N-(long-chain-acyl)ethanolamine deacylase activity
DNA-binding transcription factor binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [inference]

binding [inference]

protein binding [inference]

transcription factor binding [inference]

DNA-binding transcription factor binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

acid

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
fatty acid metabolic process
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity

Displaying 1 entry
InterPro
Acid ceramidase, N-terminal

KEGG BRITE Database

Orthology

K13720

Name

N-(long-chain-acyl)ethanolamine deacylase [EC:3.5.1.60]

References

15655246

Rhea

RHEA:17505

H₂O + N-(long-chain fatty acyl)ethanolamine

a long-chain fatty acid + ethanolamine

Enzyme

3.5.1.60

PMID

4055775

RHEA:20856

H₂O + an N-acylsphing-4-enine

a fatty acid + sphing-4-enine

Enzyme

3.5.1.23

PMID

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP014392
Gene Name: N-acylethanolamine acid amidase

Ortholog

Displaying entries **11 - 20** of 65 in total

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Species	Gene ID	Orthologous MAtrix
Sus scrofa	100521735	PIGXX33900
Nomascus leucogenys	100596863	NOMLE37190
Oreochromis niloticus	100691345	ORENI58539
Cavia porcellus	100714059	CAVPO02347
Cricetulus griseus	100769622	CRIGR23453
Otolemur garnettii	100947663	OTOGA11813
Pan paniscus	100995280	PANPA30247
Saimiri boliviensis boliviensis	101050123	SAIBB19921
Takifugu rubripes	101063012	TAKRU22050
Felis catus	101091867	FELCA09339