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transcription factor A, mitochondrial

Summary

Gene Symbol

TFAM

Organism

Homo sapiens (human)

External Links

NCBI Gene

7019

KEGG Gene ID

PubChem

7019

Alliance of Genome Resources

HGNC:11741

Annotation

Keyword

3D-structure
Activator
Alternative splicing
DNA-binding
Direct protein sequencing
Disease variant
Mitochondrion nucleoid
Nucleus
Phosphoprotein
Primary mitochondrial disease
Proteomics identification
Reference proteome
Repeat
Signal
Transcription regulation
Transit peptide

Proteins

Displaying **all 2** entries
UniProt	Protein Name
E5KSU5
Q00059	Mitochondrial transcription factor 1 Transcription factor 6 Transcription factor 6-like 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEA
mitochondrial transcription	IDA
mitochondrial transcription	IMP
mitochondrial transcription	IEA
transcription initiation at mitochondrial promoter	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

mitochondrial transcription

DNA-templated transcription initiation [inference]

transcription initiation at mitochondrial promoter

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

mitochondrial respiratory chain complex assembly

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to nutrient levels [inference]

response to nutrient

response to chemical [inference]

response to nutrient

Displaying entries **6 - 10** of 15 in total

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GO Term	Evidence Code	PMID
mitochondrion	HTP
mitochondrial matrix	NAS
mitochondrial matrix	TAS
mitochondrial matrix	IDA
mitochondrial matrix	IEA

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical structure [inference]

cytosol

nucleoid [inference]

mitochondrial nucleoid

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

mitochondrial matrix

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mitochondrial promoter sequence-specific DNA binding	IDA
mitochondrial promoter sequence-specific DNA binding	IEA
transcription coactivator binding	IEA
chromatin binding	IDA
RNA binding	HDA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

transcription regulatory region nucleic acid binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

DNA binding [inference]

double-stranded DNA binding [inference]

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

sequence-specific DNA binding

sequence-specific double-stranded DNA binding [inference]

transcription cis-regulatory region binding [inference]

mitochondrial promoter sequence-specific DNA binding

RNA binding

chromatin binding

protein binding

transcription factor binding [inference]

transcription coregulator binding [inference]

transcription coactivator binding

heat shock protein binding

transcription regulator activity [inference]

mitochondrial transcription factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

high mobility group protein

Functional Category

I: Lipid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
DNA binding, bending
transcription initiation at mitochondrial promoter

Displaying **all 2** entries
InterPro
High mobility group box domain superfamily
High mobility group box domain

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:12858	Huntington's disease	Alliance of Genome Resources
DOID:10652	Alzheimer's disease	Alliance of Genome Resources
DOID:0080337	mitochondrial DNA depletion syndrome 15	Alliance of Genome Resources
DOID:14330	Parkinson's disease	Alliance of Genome Resources
DOID:332	amyotrophic lateral sclerosis	Alliance of Genome Resources