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transforming growth factor alpha

Summary

Gene Symbol

TGFA

Organism

Homo sapiens (human)

External Links

NCBI Gene

7039

PubChem

7039

Alliance of Genome Resources

HGNC:11765

JoGo

TGFA

TogoVar

TGFA

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Disulfide bond
EGF-like domain
Glycoprotein
Growth factor
Mitogen
Palmitate
Proteomics identification
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
F8VNR3
P01135
E7EPT6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
angiogenesis
cell surface receptor signaling pathway	IDA	11278323
epidermal growth factor receptor signaling pathway	IDA	6315706
epidermal growth factor receptor signaling pathway	IBA	http://purl.obolibrary.org/obo/go/references/0000033
epidermal growth factor receptor signaling pathway	IEA	http://purl.obolibrary.org/obo/go/references/0000107

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2-EGFR signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-EGFR signaling pathway

intracellular signal transduction

cell population proliferation [inference]

epithelial cell proliferation [inference]

hepatocyte proliferation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

mammary gland alveolus development

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell division

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

cell surface receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

ERBB2-EGFR signaling pathway

ERBB2 signaling pathway [inference]

ERBB2-EGFR signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell division

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of nuclear division [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell division [inference]

positive regulation of cell division

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

regulation of cell cycle process [inference]

regulation of mitotic nuclear division [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

positive regulation of cell cycle [inference]

positive regulation of cell cycle process [inference]

positive regulation of mitotic nuclear division

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS	https://reactome.org/content/detail/R-HSA-1225978 https://reactome.org/content/detail/R-HSA-177922 https://reactome.org/content/detail/R-HSA-177923 https://reactome.org/content/detail/R-HSA-177924 https://reactome.org/content/detail/R-HSA-177925 https://reactome.org/content/detail/R-HSA-177926 https://reactome.org/content/detail/R-HSA-177927 https://reactome.org/content/detail/R-HSA-177930 https://reactome.org/content/detail/R-HSA-177933 https://reactome.org/content/detail/R-HSA-177934 https://reactome.org/content/detail/R-HSA-177935 https://reactome.org/content/detail/R-HSA-177936 https://reactome.org/content/detail/R-HSA-177937 https://reactome.org/content/detail/R-HSA-177938 https://reactome.org/content/detail/R-HSA-177939 https://reactome.org/content/detail/R-HSA-177941 https://reactome.org/content/detail/R-HSA-177942 https://reactome.org/content/detail/R-HSA-177943 https://reactome.org/content/detail/R-HSA-177944 https://reactome.org/content/detail/R-HSA-177945 https://reactome.org/content/detail/R-HSA-182969 https://reactome.org/content/detail/R-HSA-182986 https://reactome.org/content/detail/R-HSA-182990 https://reactome.org/content/detail/R-HSA-182993 https://reactome.org/content/detail/R-HSA-182994 https://reactome.org/content/detail/R-HSA-183002 https://reactome.org/content/detail/R-HSA-183036 https://reactome.org/content/detail/R-HSA-183051 https://reactome.org/content/detail/R-HSA-183055 https://reactome.org/content/detail/R-HSA-183058 https://reactome.org/content/detail/R-HSA-183067 https://reactome.org/content/detail/R-HSA-183072 https://reactome.org/content/detail/R-HSA-183084 https://reactome.org/content/detail/R-HSA-183089 https://reactome.org/content/detail/R-HSA-212706 https://reactome.org/content/detail/R-HSA-212710 https://reactome.org/content/detail/R-HSA-212713 https://reactome.org/content/detail/R-HSA-2316434 https://reactome.org/content/detail/R-HSA-2400009 https://reactome.org/content/detail/R-HSA-5672965 https://reactome.org/content/detail/R-HSA-8866279 https://reactome.org/content/detail/R-HSA-8867041 https://reactome.org/content/detail/R-HSA-8867044 https://reactome.org/content/detail/R-HSA-8867047 https://reactome.org/content/detail/R-HSA-8867754 https://reactome.org/content/detail/R-HSA-8867756 https://reactome.org/content/detail/R-HSA-8868071 https://reactome.org/content/detail/R-HSA-8868072 https://reactome.org/content/detail/R-HSA-8868230 https://reactome.org/content/detail/R-HSA-8868236 https://reactome.org/content/detail/R-HSA-8868648 https://reactome.org/content/detail/R-HSA-8868651 https://reactome.org/content/detail/R-HSA-8868661 https://reactome.org/content/detail/R-HSA-8951490 https://reactome.org/content/detail/R-HSA-9625482 https://reactome.org/content/detail/R-HSA-9625487
extracellular region	IDA	12743035 8702723
extracellular region	IBA
extracellular region	IEA	http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000107
obsolete extracellular space

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

transport vesicle membrane [inference]

ER to Golgi transport vesicle membrane

coated vesicle membrane [inference]

ER to Golgi transport vesicle membrane

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endoplasmic reticulum-Golgi intermediate compartment membrane

plasma membrane region [inference]

basolateral plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IEA
epidermal growth factor receptor binding	IDA	11278323 6315706
epidermal growth factor receptor binding	IBA	http://purl.obolibrary.org/obo/go/references/0000033
protein binding	IPI	12297049 15064403 15652357 18757723 24658140 25416956 28988771 31980649 32296183 36115835
growth factor activity	IDA	11278323

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

growth factor receptor binding [inference]

epidermal growth factor receptor binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

growth factor activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity [inference]

protein tyrosine kinase activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

signaling receptor activator activity [inference]

transmembrane receptor protein tyrosine kinase activator activity

receptor ligand activity

growth factor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

protransforming growth factor alpha

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
epidermal growth factor receptor signaling pathway
growth factor activity
positive regulation of cell population proliferation
positive regulation of mitotic nuclear division

Displaying 1 entry
InterPro
EGF-like domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2326	gastroenteritis	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements