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transketolase

Summary

Gene Symbol

Aliases

Wernicke-Korsakoff syndrome

Organism

Homo sapiens (human)

External Links

NCBI Gene

7086

HGNC

11834

KEGG Gene ID

hsa:7086

PubChem

7086

Alliance of Genome Resources

HGNC:11834

JoGo

TKT

TogoVar

TKT

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Calcium
Direct protein sequencing
Disease variant
Dwarfism
Isopeptide bond
Magnesium
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Thiamine pyrophosphate
Transferase
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P29401
V9HWD9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
pentose-phosphate shunt	IDA
pentose-phosphate shunt	IEA
pentose-phosphate shunt, non-oxidative branch	NAS
pentose-phosphate shunt, non-oxidative branch	IBA
pentose-phosphate shunt, non-oxidative branch	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

aldehyde metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

generation of precursor metabolites and energy [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pentose-phosphate shunt, non-oxidative branch

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

D-xylulose 5-phosphate metabolic process [inference]

D-xylulose 5-phosphate biosynthetic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

glyceraldehyde-3-phosphate metabolic process

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

D-xylulose 5-phosphate metabolic process [inference]

D-xylulose 5-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

biosynthetic process [inference]

aldehyde biosynthetic process [inference]

glyceraldehyde-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

carbohydrate derivative biosynthetic process [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

pyridine-containing compound metabolic process [inference]

nicotinamide nucleotide metabolic process [inference]

NADP+ metabolic process [inference]

NADPH regeneration [inference]

pentose-phosphate shunt

carbohydrate derivative metabolic process [inference]

glyceraldehyde-3-phosphate metabolic process

glucose 6-phosphate metabolic process [inference]

pentose-phosphate shunt

D-xylulose 5-phosphate metabolic process [inference]

D-xylulose 5-phosphate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

biological regulation [inference]

regulation of biological process [inference]

regulation of growth

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
nucleoplasm	IDA
cytoplasm	IEA
peroxisome	ISS
endoplasmic reticulum membrane
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

microbody [inference]

peroxisome

intracellular membraneless organelle [inference]

nuclear body

nuclear ribonucleoprotein granule [inference]

nuclear speck

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

supramolecular complex [inference]

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

nuclear speck

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
magnesium ion binding	IDA
transketolase activity	EXP
transketolase activity	IDA
transketolase activity	IBA
transketolase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transketolase or transaldolase activity

transketolase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

vitamin binding [inference]

thiamine pyrophosphate binding

ion binding [inference]

anion binding [inference]

thiamine pyrophosphate binding

cation binding [inference]

thiamine pyrophosphate binding

metal ion binding

quaternary ammonium group binding [inference]

thiamine pyrophosphate binding

heterocyclic compound binding [inference]

thiamine pyrophosphate binding

sulfur compound binding [inference]

thiamine pyrophosphate binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Transketolase

Functional Category

C: Energy production and conversion
G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
I: Lipid transport and metabolism

Displaying **all 4** entries
Gene Ontology
catalytic activity
thiamine pyrophosphate binding
transferase activity
transketolase activity

Displaying **all 6** entries
InterPro
Thiamin diphosphate-binding fold
Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
Transketolase binding site
Transketolase, C-terminal domain
Transketolase, N-terminal
Transketolase-like, pyrimidine-binding domain

Human Protein Atlas

ENSG00000163931

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00615

Name

transketolase [EC:2.2.1.1]

References

8419340

Rhea

RHEA:27626

D-erythrose 4-phosphate + D-xylulose 5-phosphate

β-D-fructose 6-phosphate + D-glyceraldehyde 3-phosphate

Enzyme

2.2.1.1

RHEA:10508

D-sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

D-xylulose 5-phosphate + aldehydo-D-ribose 5-phosphate

Enzyme

2.2.1.1

PMID

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 30 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000107	Renal cyst
HP:0000365	Hearing impairment
HP:0000486	Strabismus
HP:0000509	Conjunctivitis
HP:0000518	Cataract
HP:0000519	Developmental cataract
HP:0000554	Uveitis
HP:0000722	Compulsive behaviors
HP:0000733	Motor stereotypy