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toll like receptor 3

Summary

Gene Symbol

TLR3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7098

PubChem

7098

Alliance of Genome Resources

HGNC:11849

JoGo

TLR3

TogoVar

TLR3

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Disease variant
Disulfide bond
Endoplasmic reticulum
Endosome
Glycoprotein
Inflammatory response
Innate immunity
Isopeptide bond
Leucine-rich repeat
Phosphoprotein
Proteomics identification
RNA-binding
Receptor
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
O15455

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 63 in total

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GO Term	Evidence Code	PMID
MAPK cascade	IEA
microglial cell activation
toll-like receptor signaling pathway	IDA
regulation of immune system process	IEA
regulation of dendritic cell cytokine production

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response [inference]

innate immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

microglial cell activation

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

intracellular signal transduction

intracellular receptor signaling pathway [inference]

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

intracellular signaling cassette [inference]

MAPK cascade

JNK cascade

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

necroptotic signaling pathway

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type III interferon production

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

type III interferon production

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to dsRNA [inference]

cellular response to exogenous dsRNA

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

reproductive process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

microglial cell activation

cytokine production [inference]

type III interferon production

developmental process [inference]

developmental process involved in reproduction [inference]

reproductive structure development [inference]

gonad development [inference]

male gonad development

anatomical structure development [inference]

animal organ development [inference]

gonad development [inference]

male gonad development

reproductive structure development [inference]

gonad development [inference]

male gonad development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

inflammatory response to wounding

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to osmotic stress [inference]

hyperosmotic response

response to wounding [inference]

inflammatory response to wounding

immune response [inference]

innate immune response

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus [inference]

response to bacterium [inference]

defense response to bacterium

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response

response to abiotic stimulus [inference]

response to osmotic stress [inference]

hyperosmotic response

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to dsRNA [inference]

cellular response to exogenous dsRNA

response to peptide [inference]

response to cytokine [inference]

response to type II interferon [inference]

cellular response to type II interferon

response to interferon-beta [inference]

cellular response to interferon-beta

cellular response to cytokine stimulus [inference]

response to nitrogen compound [inference]

response to dsRNA

response to exogenous dsRNA

cellular response to exogenous dsRNA

cellular response to dsRNA [inference]

cellular response to exogenous dsRNA

cellular response to nitrogen compound [inference]

cellular response to dsRNA [inference]

cellular response to exogenous dsRNA

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to xenobiotic stimulus

cellular response to nitrogen compound [inference]

cellular response to dsRNA [inference]

cellular response to exogenous dsRNA

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process

negative regulation of immune system process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of immune effector process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of leukocyte mediated immunity [inference]

regulation of dendritic cell cytokine production

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune effector process [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of immune system process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of inflammatory response [inference]

positive regulation of inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

positive regulation of inflammatory response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

regulation of inflammatory response [inference]

positive regulation of inflammatory response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-activating signaling pathway [inference]

innate immune response-activating signaling pathway [inference]

pattern recognition receptor signaling pathway [inference]

toll-like receptor signaling pathway

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

cell surface receptor signaling pathway [inference]

extrinsic apoptotic signaling pathway

intracellular signal transduction

intracellular receptor signaling pathway [inference]

cytoplasmic pattern recognition receptor signaling pathway [inference]

endolysosomal toll-like receptor signaling pathway [inference]

toll-like receptor 3 signaling pathway

intracellular signaling cassette [inference]

MAPK cascade

JNK cascade

apoptotic signaling pathway [inference]

extrinsic apoptotic signaling pathway

necroptotic signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of intracellular signal transduction [inference]

regulation of canonical NF-kappaB signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of JNK cascade [inference]

positive regulation of JNK cascade

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of type III interferon production [inference]

positive regulation of type III interferon production

regulation of cytokine production involved in inflammatory response [inference]

positive regulation of cytokine production involved in inflammatory response

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of type III interferon production [inference]

positive regulation of type III interferon production

regulation of cytokine production involved in inflammatory response [inference]

positive regulation of cytokine production involved in inflammatory response

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of production of molecular mediator of immune response [inference]

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of production of molecular mediator of immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of canonical NF-kappaB signal transduction

positive regulation of MAPK cascade [inference]

positive regulation of JNK cascade

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

regulation of cytokine production involved in immune response [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

regulation of dendritic cell cytokine production

regulation of macrophage cytokine production [inference]

positive regulation of macrophage cytokine production

regulation of type I interferon production [inference]

positive regulation of type I interferon production [inference]

regulation of interferon-alpha production [inference]

positive regulation of interferon-alpha production

regulation of interferon-beta production [inference]

positive regulation of interferon-beta production

regulation of chemokine production [inference]

positive regulation of chemokine production

regulation of type II interferon production [inference]

positive regulation of type II interferon production

regulation of interleukin-12 production [inference]

positive regulation of interleukin-12 production

regulation of interleukin-6 production [inference]

positive regulation of interleukin-6 production

regulation of interleukin-8 production [inference]

positive regulation of interleukin-8 production

regulation of type III interferon production [inference]

positive regulation of type III interferon production

regulation of cytokine production involved in inflammatory response [inference]

positive regulation of cytokine production involved in inflammatory response

regulation of tumor necrosis factor superfamily cytokine production [inference]

regulation of tumor necrosis factor production [inference]

positive regulation of tumor necrosis factor production

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of cytokine production involved in immune response [inference]

positive regulation of myeloid leukocyte cytokine production involved in immune response [inference]

positive regulation of macrophage cytokine production

positive regulation of type I interferon production [inference]

positive regulation of tumor necrosis factor superfamily cytokine production [inference]

positive regulation of tumor necrosis factor production

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of myeloid cell differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of leukocyte differentiation [inference]

regulation of myeloid leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of osteoclast differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

negative regulation of hemopoiesis [inference]

negative regulation of leukocyte differentiation [inference]

negative regulation of myeloid leukocyte differentiation [inference]

negative regulation of osteoclast differentiation

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

activation of protein kinase activity [inference]

activation of NF-kappaB-inducing kinase activity

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
Golgi membrane	TAS
cytoplasm	IDA
lysosomal membrane	HDA
early endosome	EXP
early endosome	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

endolysosome membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endolysosome membrane

endosome membrane

endolysosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
double-stranded RNA binding	NAS
double-stranded RNA binding	IDA
double-stranded RNA binding	IBA
transmembrane signaling receptor activity	NAS
transmembrane signaling receptor activity	IDA

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding [inference]

double-stranded RNA binding

protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding

identical protein binding

molecular transducer activity [inference]

signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Toll-like receptor 3

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
immune response
immune system process
inflammatory response
toll-like receptor signaling pathway

Displaying **all 8** entries
InterPro
Cysteine-rich flanking region, C-terminal
Leucine-rich repeat domain superfamily
Leucine-rich repeat, typical subtype
Leucine-rich repeat
Toll-like receptor 3 trans-membrane domain
Toll-like receptor
Toll/interleukin-1 receptor homology (TIR) domain superfamily
Toll/interleukin-1 receptor homology (TIR) domain

Disease

Disease Ontology

Displaying **all 7** entries
DO ID	Disease Name	Source
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2841	asthma	Alliance of Genome Resources
DOID:5082	liver cirrhosis	Alliance of Genome Resources
DOID:526	human immunodeficiency virus infectious disease	Alliance of Genome Resources
DOID:612	primary immunodeficiency disease	Alliance of Genome Resources
DOID:9744	type 1 diabetes mellitus	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements