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complement C1q A chain

Summary

Gene Symbol

C1QA

Organism

Homo sapiens (human)

External Links

NCBI Gene

712

PubChem

712

Alliance of Genome Resources

HGNC:1241

JoGo

C1QA

TogoVar

C1QA

Annotation

Keyword

3D-structure
Collagen
Complement pathway
Direct protein sequencing
Disulfide bond
Glycoprotein
Host-virus interaction
Hydroxylation
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P02745

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
microglial cell activation	ISS
complement activation	TAS	9461517
complement activation, classical pathway	NAS	11527969
complement activation, classical pathway	IDA	29449492
cell-cell signaling	TAS	9461517

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

cell communication [inference]

cell-cell signaling

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

cell junction disassembly [inference]

synapse pruning

complement-mediated synapse pruning

cell junction organization [inference]

synapse organization

synapse pruning

complement-mediated synapse pruning

cell junction disassembly [inference]

synapse pruning

complement-mediated synapse pruning

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

leukocyte activation involved in inflammatory response [inference]

microglial cell activation

myeloid leukocyte activation [inference]

macrophage activation [inference]

microglial cell activation

glial cell activation [inference]

pattern specification process [inference]

regionalization [inference]

vertebrate eye-specific patterning

developmental process [inference]

developmental maturation [inference]

anatomical structure maturation [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

cellular developmental process [inference]

cell maturation [inference]

neuron maturation [inference]

neuron remodeling

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

signaling [inference]

cell-cell signaling

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
extracellular region	NAS	28104818
extracellular region	TAS
extracellular region	IDA	18250442
collagen trimer	IEA
complement component C1 complex	NAS	28104818

GO Hierarchy

cellular component

protein-containing complex [inference]

cellular anatomical entity [inference]

extracellular region

extrinsic component of membrane [inference]

extrinsic component of plasma membrane [inference]

extrinsic component of synaptic membrane [inference]

cell junction [inference]

synapse

glutamatergic synapse

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

postsynapse

Displaying **all 2** entries
GO Term	Evidence Code	PMID
amyloid-beta binding	TAS	15269255
protein binding	IPI	12960167 21054788 21988832 28018340 28325905 32296183 34804054 7240

GO Hierarchy

molecular function

binding [inference]

protein binding

amide binding [inference]

peptide binding [inference]

amyloid-beta binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Complement C1q subcomponent subunit A

Functional Category

O: Posttranslational modification, protein turnover, chaperones
P: Inorganic ion transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
C1q domain
Collagen triple helix repeat
Tumour necrosis factor-like domain superfamily

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2921	glomerulonephritis	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 54** of 54 in total

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Species	Gene ID	Orthologous MAtrix
Ursus americanus	123782397	URSAM05812
Serinus canaria	127060352	SERCA21660
Pan troglodytes	129135278	PANTR20200
Gorilla gorilla gorilla	129533651	GORGO20504

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements