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heat shock protein 90 beta family member 1

Summary

Gene Symbol

HSP90B1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7184

PubChem

7184

Alliance of Genome Resources

HGNC:12028

JoGo

HSP90B1

TogoVar

HSP90B1

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Calcium
Chaperone
Direct protein sequencing
Disulfide bond
Endoplasmic reticulum
Glycoprotein
Hydrolase
Hydroxylation
Phosphoprotein
Proteomics identification
Reference proteome
Sarcoplasmic reticulum
Signal
Stress response

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P14625	94 kDa glucose-regulated protein Heat shock protein 90 kDa beta member 1 Heat shock protein family C member 4 Tumor rejection antigen 1 gp96 homolog
V9HWP2	Heat shock protein 90 kDa beta member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IDA	15620698
protein folding	IDA	23572575
protein folding	IBA
protein transport	NAS	15845869
positive regulation of Wnt signaling pathway	IDA	23572575 39509507

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

proteolysis involved in protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

organonitrogen compound catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cellular process [inference]

protein folding

protein folding in endoplasmic reticulum

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

maintenance of location in cell [inference]

sequestering of calcium ion

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

actin filament bundle assembly [inference]

actin rod assembly

supramolecular fiber organization [inference]

actin filament organization [inference]

actin filament bundle organization [inference]

actin filament bundle assembly [inference]

actin rod assembly

response to stimulus [inference]

response to stress [inference]

response to hypoxia

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

ERAD pathway

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organic cyclic compound [inference]

cellular response to ATP

response to organophosphorus [inference]

response to ATP [inference]

cellular response to ATP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to inorganic substance [inference]

response to metal ion [inference]

response to manganese ion [inference]

cellular response to manganese ion

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to ATP [inference]

cellular response to ATP

ERAD pathway

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

response to oxygen-containing compound [inference]

response to ATP [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

response to salt [inference]

response to ATP [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress

ERAD pathway

cellular response to chemical stimulus [inference]

cellular response to inorganic substance [inference]

cellular response to metal ion [inference]

cellular response to manganese ion

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to ATP

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to ATP

cellular response to oxygen-containing compound [inference]

cellular response to ATP

cellular response to salt [inference]

cellular response to ATP

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

organic substance transport [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

nitrogen compound transport [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

maintenance of location [inference]

maintenance of location in cell [inference]

sequestering of calcium ion

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

endoplasmic reticulum to cytosol transport [inference]

retrograde protein transport, ER to cytosol

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to plasma membrane

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport

intracellular protein transport [inference]

protein exit from endoplasmic reticulum [inference]

retrograde protein transport, ER to cytosol

protein localization to membrane [inference]

protein localization to plasma membrane

protein localization to cell periphery [inference]

protein localization to plasma membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

regulation of phosphoprotein phosphatase activity

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein dephosphorylation [inference]

regulation of phosphoprotein phosphatase activity

regulation of macromolecule metabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein dephosphorylation [inference]

regulation of phosphoprotein phosphatase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein dephosphorylation [inference]

regulation of phosphoprotein phosphatase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway

regulation of pattern recognition receptor signaling pathway [inference]

regulation of toll-like receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

regulation of cellular metabolic process [inference]

regulation of phosphorus metabolic process [inference]

regulation of phosphate metabolic process [inference]

regulation of dephosphorylation [inference]

regulation of phosphatase activity [inference]

regulation of phosphoprotein phosphatase activity

regulation of protein dephosphorylation [inference]

regulation of phosphoprotein phosphatase activity

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway

positive regulation of pattern recognition receptor signaling pathway [inference]

positive regulation of toll-like receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of phosphatase activity [inference]

regulation of phosphoprotein phosphatase activity

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
nucleus	HDA	21630459
endoplasmic reticulum	TAS	16130169
endoplasmic reticulum	IDA	17344063 30188326
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

protein-containing complex

endoplasmic reticulum protein-containing complex [inference]

endoplasmic reticulum chaperone complex

cellular anatomical entity [inference]

membrane

plasma membrane [inference]

sperm plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

cell junction [inference]

anchoring junction [inference]

cell-substrate junction [inference]

focal adhesion

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

midbody

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

endoplasmic reticulum lumen

sarcoplasmic reticulum lumen

endocytic vesicle lumen

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

endoplasmic reticulum

smooth endoplasmic reticulum

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

pigment granule [inference]

melanosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

perinuclear region of cytoplasm

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
RNA binding	IDA	11958450
protein phosphatase inhibitor activity	IDA	19000834
calcium ion binding	TAS	10497210
protein binding	IPI	11907036 11958450 15845869 18264092 23349634 23995768 26496610 30021884 32812023 32814053 35063084 9596688
ATP binding	IBA