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izumo sperm-egg fusion 1

Summary

Gene Symbol

Izumo1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

73456

KEGG Gene ID

PubChem

73456

Alliance of Genome Resources

MGI:1920706

Annotation

Keyword

3D-structure
Cell membrane
Cytoplasmic vesicle
Disulfide bond
Fertilization
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9D9J7	Oocyte binding/fusion factor Sperm-specific protein izumo
A0A455R725

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
syncytium formation by cell-cell fusion	IMP
cell adhesion	IC
signal transduction	IEA
binding of sperm to zona pellucida	ISO
binding of sperm to zona pellucida	IBA

GO Hierarchy

biological process

cellular process [inference]

cell adhesion

cell-cell adhesion [inference]

heterotypic cell-cell adhesion

signal transduction

cell recognition [inference]

cell-cell recognition [inference]

sperm-egg recognition

binding of sperm to zona pellucida

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cell-cell fusion [inference]

syncytium formation by cell-cell fusion

reproductive process [inference]

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction

Displaying entries **1 - 5** of 15 in total

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GO Term	Evidence Code	PMID
acrosomal vesicle	IDA
acrosomal membrane	IDA
acrosomal membrane	IBA
acrosomal membrane	IEA
endoplasmic reticulum membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein complex involved in cell adhesion [inference]

protein complex involved in cell-cell adhesion

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

acrosomal vesicle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	ISO
signaling receptor binding	IPI
signaling receptor binding	IEA
protein binding	IPI
identical protein binding	ISO

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

identical protein binding

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

cell adhesion molecule binding [inference]

cell adhesion mediator activity [inference]

cell-cell adhesion mediator activity [inference]

protein binding involved in heterotypic cell-cell adhesion

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

izumo sperm-egg fusion protein 1

Functional Category

M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
fusion of sperm to egg plasma membrane involved in single fertilization
protein binding involved in heterotypic cell-cell adhesion
signaling receptor binding
sperm-egg recognition