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UDP-glucose pyrophosphorylase 2

Summary

Gene Symbol

UGP2

Aliases

SVUGP2
UGPP1
UTP--glucose-1-phosphate uridylyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

7360

HGNC

12527

KEGG Gene ID

hsa:7360

PubChem

7360

Alliance of Genome Resources

HGNC:12527

JoGo

UGP2

TogoVar

UGP2

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Disease variant
Epilepsy
Magnesium
Metal-binding
Nucleotidyltransferase
Phosphoprotein
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q16851	UDP-glucose pyrophosphorylase
A0A140VKE1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
glycogen metabolic process	IBA
glycogen biosynthetic process	IMP
glycogen biosynthetic process	IEA
UDP-alpha-D-glucose metabolic process	TAS
UDP-alpha-D-glucose metabolic process	IDA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

generation of precursor metabolites and energy [inference]

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-alpha-D-glucose metabolic process

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

glucose 1-phosphate metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-alpha-D-glucose metabolic process

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

glucose 1-phosphate metabolic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

UDP-glucuronate biosynthetic process

organophosphate biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

macromolecule biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

glucan metabolic process [inference]

glycogen metabolic process

glycogen biosynthetic process

glucan biosynthetic process [inference]

glycogen biosynthetic process

carbohydrate biosynthetic process [inference]

polysaccharide biosynthetic process [inference]

glucan biosynthetic process [inference]

glycogen biosynthetic process

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-alpha-D-glucose metabolic process

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

UDP-glucuronate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

carboxylic acid biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

UDP-glucuronate biosynthetic process

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-alpha-D-glucose metabolic process

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

nucleoside phosphate biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

carbohydrate derivative metabolic process [inference]

nucleotide-sugar metabolic process [inference]

UDP-alpha-D-glucose metabolic process

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

UDP-glucuronate metabolic process [inference]

UDP-glucuronate biosynthetic process

glucose 1-phosphate metabolic process

carbohydrate derivative biosynthetic process [inference]

nucleotide-sugar biosynthetic process [inference]

UDP-glucuronate biosynthetic process

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	HDA
cytoplasm	EXP
cytoplasm	IBA
cytoplasm	IEA
cytosol	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
UTP:glucose-1-phosphate uridylyltransferase activity	TAS
UTP:glucose-1-phosphate uridylyltransferase activity	IDA
UTP:glucose-1-phosphate uridylyltransferase activity	IMP
UTP:glucose-1-phosphate uridylyltransferase activity	IBA
UTP:glucose-1-phosphate uridylyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

uridylyltransferase activity

UTP-monosaccharide-1-phosphate uridylyltransferase activity

UTP:glucose-1-phosphate uridylyltransferase activity

binding [inference]

protein binding

identical protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

D-glucose binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

monosaccharide binding [inference]

D-glucose binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

pyrimidine nucleotide binding [inference]

pyrimidine ribonucleotide binding

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

pyrimidine nucleotide binding [inference]

pyrimidine ribonucleotide binding

ribonucleotide binding [inference]

pyrimidine ribonucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE

Functional Category

G: Carbohydrate transport and metabolism
H: Coenzyme transport and metabolism
T: Signal transduction mechanisms

Displaying **all 6** entries
Gene Ontology
UDP-glucose metabolic process
UTP
glycogen metabolic process
nucleotidyltransferase activity
transferase activity
uridylyltransferase activity

Displaying **all 3** entries
InterPro
Nucleotide-diphospho-sugar transferases
UDPGP family
UTP--glucose-1-phosphate uridylyltransferase

Human Protein Atlas

ENSG00000169764

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

Rhea

RHEA:19889

H⁺ + UTP + α-D-glucose 1-phosphate

diphosphate + UDP-α-D-glucose

Enzyme

2.7.7.9

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0112218	developmental and epileptic encephalopathy 83	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of 31 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000252	Microcephaly
HP:0000286	Epicanthus
HP:0000340	Sloping forehead
HP:0000341	Narrow forehead
HP:0000343	Long philtrum
HP:0000369	Low-set ears
HP:0000639	Nystagmus
HP:0000664	Synophrys
HP:0000817	Reduced eye contact