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UDP glycosyltransferase 8

Summary

Gene Symbol

UGT8

Aliases

2-hydroxyacylsphingosine 1-beta-galactosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

7368

GGDB ID

gg084

HGNC

12555

mRNA

NM_003360

map

4q26

Protein

NP_003351

OMIM

601291

KEGG Gene ID

hsa:7368

PubChem

7368

Alliance of Genome Resources

HGNC:12555

JoGo

UGT8

TogoVar

UGT8

Annotation

Keyword

Endoplasmic reticulum
Glycoprotein
Glycosyltransferase
Proteomics identification
Reference proteome
Signal
Sphingolipid metabolism
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q16880	Ceramide UDP-galactosyltransferase Cerebroside synthase UDP-galactose-ceramide galactosyltransferase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
protein localization to paranode region of axon	IEA
galactosylceramide biosynthetic process	ISS
galactosylceramide biosynthetic process	IBA
galactosylceramide biosynthetic process	IEA
glycosphingolipid biosynthetic process	TAS

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

galactosylceramide biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

sphingolipid metabolic process [inference]

ceramide metabolic process [inference]

glycosylceramide metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

galactosylceramide biosynthetic process

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

galactosylceramide biosynthetic process

lipid biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

sphingolipid biosynthetic process [inference]

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

ceramide biosynthetic process [inference]

galactosylceramide biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

glycosphingolipid metabolic process [inference]

glycosylceramide metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

glycolipid biosynthetic process

glycosphingolipid biosynthetic process

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

galactolipid metabolic process [inference]

galactosylceramide metabolic process [inference]

galactosylceramide biosynthetic process

galactolipid biosynthetic process [inference]

galactosylceramide biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

cellular component assembly [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

paranodal junction assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis

anatomical structure formation involved in morphogenesis [inference]

cellular component assembly involved in morphogenesis [inference]

paranodal junction assembly

anatomical structure development [inference]

system development [inference]

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to axon [inference]

protein localization to paranode region of axon

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GO Term	Evidence Code	PMID
endoplasmic reticulum	ISS
endoplasmic reticulum	IBA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	TAS
membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
N-acylsphingosine galactosyltransferase activity	ISS
N-acylsphingosine galactosyltransferase activity	TAS
N-acylsphingosine galactosyltransferase activity	IBA
N-acylsphingosine galactosyltransferase activity	IEA
UDP-glycosyltransferase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

UDP-galactosyltransferase activity [inference]

hexosyltransferase activity

galactosyltransferase activity [inference]

UDP-galactosyltransferase activity [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

glucuronosyltransferase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
UDP-glycosyltransferase activity
transferase activity

Displaying **all 2** entries
InterPro
UDP-glucuronosyl/UDP-glucosyltransferase
UDP-glycosyltransferase family, conserved site

Human Protein Atlas

ENSG00000174607

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg084

Gene Symbol

UGT8

Orthologous Gene

Displaying **all 3** entries
Species	Protein	mRNA
Mus musculus	NP_035804	NM_011674
Drosophila melanogaster	NP_724419	NM_165438
Rattus norvegicus	NP_062149	NM_019276

KEGG BRITE Database

Orthology

K04628

Name

ceramide galactosyltransferase [EC:2.4.1.47]

References

Rhea

RHEA:10856

a N-(2-hydroxyacyl)sphing-4-enine + UDP-α-D-galactose

H⁺ + a 1-(β-D-galactosyl)-2-(2-hydroxyacyl)sphing-4-enine + UDP

Enzyme

2.4.1.47

PMID

RHEA:13093

an N-acylsphing-4-enine + UDP-α-D-galactose

H⁺ + a β-D-galactosyl-(1↔1ʼ)-N-acylsphing-4-enine + UDP

Enzyme

2.4.1.47

PMID

5807218

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP002504
Gene Name: UDP glycosyltransferase 8

Ortholog

Displaying entries **1 - 10** of 29 in total

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Species	Gene ID	Alliance of Genome Resources
Mus musculus	22239	MGI:109522
Rattus norvegicus	50555	RGD:3938
Caenorhabditis elegans	174507	WB:WBGene00009450
Caenorhabditis elegans	176904	WB:WBGene00018931
Caenorhabditis elegans	179446	WB:WBGene00007070
Caenorhabditis elegans	179449	WB:WBGene00007072
Caenorhabditis elegans	180404	WB:WBGene00015141
Caenorhabditis elegans	181205	WB:WBGene00007650
Caenorhabditis elegans	185500	WB:WBGene00018206
Caenorhabditis elegans	188072	WB:WBGene00011452

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements