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Guidelines

MIRAGE

uromodulin

Summary

Gene Symbol

UMOD

Aliases

Tamm-Horsfall glycoprotein
uromucoid

Organism

Homo sapiens (human)

External Links

NCBI Gene

7369

HGNC

12559

KEGG Gene ID

hsa:7369

PubChem

7369

Alliance of Genome Resources

HGNC:12559

JoGo

UMOD

TogoVar

UMOD

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Ciliopathy
Cilium
Direct protein sequencing
Disease variant
Disulfide bond
EGF-like domain
GPI-anchor
Innate immunity
Nephronophthisis
Proteomics identification
Reference proteome
Repeat
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
P07911	Tamm-Horsfall urinary glycoprotein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 50 in total

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GO Term	Evidence Code	PMID
organ or tissue specific immune response
renal water homeostasis
glomerular filtration
protein folding
lipid metabolic process

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular process [inference]

protein folding

cell adhesion [inference]

cell-cell adhesion [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

metabolic process [inference]

catabolic process [inference]

autophagy

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

macromolecule biosynthetic process [inference]

gene expression

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

primary metabolic process [inference]

RNA processing [inference]

RNA splicing

lipid metabolic process

protein metabolic process [inference]

protein catabolic process [inference]

proteasomal protein catabolic process [inference]

ERAD pathway

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

myeloid leukocyte migration [inference]

granulocyte migration [inference]

neutrophil migration

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

transmembrane transport [inference]

urea transmembrane transport

process utilizing autophagic mechanism [inference]

autophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

endoplasmic reticulum organization

membrane organization [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water homeostasis

renal sodium ion transport [inference]

renal sodium ion absorption

renal absorption [inference]

renal sodium ion absorption

renal filtration [inference]

glomerular filtration

renal tubular secretion [inference]

renal urate salt excretion

excretion [inference]

micturition

renal tubular secretion [inference]

renal urate salt excretion

multicellular organismal response to stress

tissue remodeling [inference]

connective tissue replacement

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

metanephric epithelium development [inference]

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

metanephric nephron epithelium development [inference]

metanephric nephron tubule development [inference]

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

ascending thin limb development [inference]

metanephric ascending thin limb development

thick ascending limb development [inference]

metanephric thick ascending limb development

distal convoluted tubule development [inference]

metanephric distal convoluted tubule development

metanephric nephron tubule development [inference]

collecting duct development

metanephric tubule development [inference]

metanephric nephron tubule development [inference]

juxtaglomerular apparatus development

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

multicellular organismal-level homeostasis [inference]

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

chemical homeostasis [inference]

monoatomic ion homeostasis

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

monoatomic cation homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

monoatomic anion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic anion homeostasis [inference]

intracellular chloride ion homeostasis

intracellular monoatomic cation homeostasis [inference]

intracellular phosphate ion homeostasis

inorganic ion homeostasis [inference]

phosphate ion homeostasis [inference]

intracellular phosphate ion homeostasis

chloride ion homeostasis [inference]

intracellular chloride ion homeostasis

calcium ion homeostasis [inference]

intracellular calcium ion homeostasis

potassium ion homeostasis

sodium ion homeostasis [inference]

intracellular sodium ion homeostasis

multicellular organismal-level chemical homeostasis [inference]

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to water deprivation

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

multicellular organismal response to stress

response to topologically incorrect protein [inference]

response to unfolded protein [inference]

cellular response to unfolded protein

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

immune response [inference]

organ or tissue specific immune response

innate immune response [inference]

antibacterial innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to molecule of bacterial origin [inference]

response to lipopolysaccharide

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to other organism [inference]

defense response to symbiont [inference]

innate immune response [inference]

antibacterial innate immune response

response to abiotic stimulus [inference]

response to water [inference]

response to water deprivation

response to chemical [inference]

response to acid chemical [inference]

response to water [inference]

response to water deprivation

response to xenobiotic stimulus

response to lipid [inference]

response to lipopolysaccharide

ERAD pathway

response to oxygen-containing compound [inference]

response to water [inference]

response to water deprivation

response to lipopolysaccharide

cellular response to stimulus [inference]

cellular response to stress [inference]

response to endoplasmic reticulum stress [inference]

ERAD pathway

cellular response to topologically incorrect protein [inference]

cellular response to unfolded protein

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to organelle [inference]

protein localization to vacuole

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to cell periphery [inference]

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

protein localization to extracellular region

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

sodium ion transport [inference]

renal sodium ion transport [inference]

renal sodium ion absorption

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

organic anion transport [inference]

urate transport

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

organic acid transport [inference]

carboxylic acid transport [inference]

tricarboxylic acid transport [inference]

citrate transport [inference]

citric acid secretion

one-carbon compound transport [inference]

urea transport [inference]

urea transmembrane transport

secretion [inference]

acid secretion [inference]

citric acid secretion

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

transmembrane transport [inference]

urea transmembrane transport

nitrogen compound transport [inference]

urate transport

urea transport [inference]

urea transmembrane transport

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein transport within lipid bilayer [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to membrane raft [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

protein localization to plasma membrane raft [inference]

protein transport into plasma membrane raft

establishment of protein localization to membrane [inference]

protein transport into membrane raft [inference]

protein transport into plasma membrane raft

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport

regulation of transport [inference]

regulation of protein transport

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

tumor necrosis factor-mediated signaling pathway

apoptotic signaling pathway

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

regulation of biological quality [inference]

regulation of blood pressure

regulation of body fluid levels [inference]

regulation of urine volume

multicellular organismal-level water homeostasis [inference]

renal water homeostasis

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
spindle pole	IDA
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
endoplasmic reticulum	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

microtubule organizing center [inference]

spindle pole body [inference]

mitotic spindle pole body

cell surface

plasma membrane

organelle membrane [inference]

bounding membrane of organelle [inference]

ciliary membrane

plasma membrane region [inference]

cell projection membrane [inference]

ciliary membrane

extrinsic component of membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA
protein binding	IPI
IgG binding	IDA

GO Hierarchy

molecular function

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

immunoglobulin binding [inference]

IgG binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Pancreatic secretory granule membrane major glycoprotein GP2

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 3** entries
InterPro
EGF-like domain
Zona pellucida domain
Zona pellucida, ZP-C domain

KEGG BRITE Database

Orthology

K18274

Name

uromodulin

References

20798515

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060062	autosomal dominant tubulointerstitial kidney disease	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 10** entries
HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000083	Renal insufficiency
HP:0000092	Renal tubular atrophy
HP:0000112	Nephropathy
HP:0000123	Nephritis
HP:0001997	Gout
HP:0002149	Hyperuricemia
HP:0003621	Juvenile onset
HP:0003676	Progressive
HP:0012213	Decreased glomerular filtration rate

Displaying 1 entry
Disease ID	Disease Name
OMIM:162000	familial juvenile hyperuricemic nephropathy type 1

PubChem Disease

GHR Health Conditions

Uromodulin-associated kidney disease

MedGen Diseases

Familial juvenile hyperuricemic nephropathy type 1

OMIM Phenotypes

TUBULOINTERSTITIAL KIDNEY DISEASE, AUTOSOMAL DOMINANT, 1; ADTKD1

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22242	MGI:102674
Rattus norvegicus	25128	RGD:3940

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026