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Guidelines

MIRAGE

valyl-tRNA synthetase 1

Summary

Gene Symbol

VARS1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7407

KEGG Gene ID

PubChem

7407

Alliance of Genome Resources

HGNC:12651

Annotation

Keyword

ATP-binding
Acetylation
Alternative splicing
Aminoacyl-tRNA synthetase
Coiled coil
Direct protein sequencing
Disease variant
Epilepsy
Intellectual disability
Phosphoprotein
Protein biosynthesis
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A024RCN6	Valyl-tRNA synthetase
P26640	Protein G7a Valyl-tRNA synthetase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
tRNA aminoacylation for protein translation	TAS
tRNA aminoacylation for protein translation	IEA
valyl-tRNA aminoacylation	IBA
valyl-tRNA aminoacylation	IEA
aminoacyl-tRNA metabolism involved in translational fidelity	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

valyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

valyl-tRNA aminoacylation

aminoacyl-tRNA metabolism involved in translational fidelity

amino acid metabolic process [inference]

amino acid activation [inference]

tRNA aminoacylation [inference]

tRNA aminoacylation for protein translation

valyl-tRNA aminoacylation

biological regulation [inference]

regulation of biological quality [inference]

regulation of translational fidelity [inference]

aminoacyl-tRNA metabolism involved in translational fidelity

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
endoplasmic reticulum
cytosol	TAS
cytosol	IDA
cytosol	IBA
sperm midpiece

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying entries **1 - 5** of 9 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
nucleotide binding	IEA
aminoacyl-tRNA deacylase activity	IEA
aminoacyl-tRNA ligase activity	IEA
valine-tRNA ligase activity	TAS
valine-tRNA ligase activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

carboxylic ester hydrolase activity [inference]

aminoacyl-tRNA deacylase activity

ligase activity [inference]

ligase activity, forming carbon-oxygen bonds [inference]

aminoacyl-tRNA ligase activity

valine-tRNA ligase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

catalytic activity, acting on a tRNA [inference]

aminoacyl-tRNA deacylase activity

aminoacyl-tRNA ligase activity

valine-tRNA ligase activity

deacylase activity [inference]

aminoacyl-tRNA deacylase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22321	MGI:90675

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026