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Guidelines

MIRAGE

voltage dependent anion channel 1

Summary

Gene Symbol

VDAC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7416

KEGG Gene ID

PubChem

7416

Alliance of Genome Resources

HGNC:12669

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Apoptosis
Cell membrane
Direct protein sequencing
Host-virus interaction
Isopeptide bond
Lipid transport
Lipid-binding
Mitochondrion outer membrane
NAD
Phosphoprotein
Porin
Proteomics identification
Reference proteome
Transmembrane beta strand
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KTS5	Voltage-dependent anion-selective channel protein 1
P21796	Outer mitochondrial membrane protein porin 1 Plasmalemmal porin Porin 31HL Porin 31HM Voltage-dependent anion-selective channel protein 1
A0A1L1UHR1	Voltage-dependent anion-selective channel protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 22 in total

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GO Term	Evidence Code	PMID
behavioral fear response
anion transport	IDA
monoatomic anion transport	IDA
lipid transport
apoptotic process	TAS

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

small molecule metabolic process [inference]

organic acid metabolic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

oxoacid metabolic process [inference]

carboxylic acid metabolic process [inference]

monocarboxylic acid metabolic process [inference]

pyruvate metabolic process [inference]

pyruvate biosynthetic process

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

small molecule biosynthetic process [inference]

organic acid biosynthetic process [inference]

carboxylic acid biosynthetic process [inference]

monocarboxylic acid biosynthetic process [inference]

pyruvate biosynthetic process

cell death [inference]

programmed cell death [inference]

apoptotic process

intercellular transport [inference]

calcium import into the mitochondrion

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular localization [inference]

intracellular transport [inference]

mitochondrial transport [inference]

mitochondrial transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic anion transmembrane transport

mitochondrial transmembrane transport

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic anion transport

monoatomic anion transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic anion transmembrane transport

lipid transport

intercellular transport [inference]

calcium import into the mitochondrion

intracellular transport [inference]

mitochondrial transport [inference]

mitochondrial transmembrane transport

transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

mitochondrial calcium ion transmembrane transport [inference]

calcium import into the mitochondrion

monoatomic anion transmembrane transport

mitochondrial transmembrane transport

establishment of localization in cell [inference]

intracellular transport [inference]

mitochondrial transport [inference]

mitochondrial transmembrane transport

cellular localization [inference]

intracellular transport [inference]

mitochondrial transport [inference]

mitochondrial transmembrane transport

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling [inference]

synaptic signaling [inference]

trans-synaptic signaling [inference]

anterograde trans-synaptic signaling [inference]

chemical synaptic transmission [inference]

neuron-neuron synaptic transmission

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

negative regulation of transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of monoatomic ion transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of autophagy [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of mitophagy

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of type 2 mitophagy [inference]

positive regulation of type 2 mitophagy

regulation of autophagy of mitochondrion

regulation of mitophagy

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of type 2 mitophagy [inference]

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

regulation of reactive oxygen species metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

regulation of transmembrane transport [inference]

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic ion transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport [inference]

regulation of calcium import into the mitochondrion [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of autophagy of mitochondrion [inference]

positive regulation of mitophagy

positive regulation of type 2 mitophagy

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of reactive oxygen species metabolic process

negative regulation of transmembrane transport [inference]

negative regulation of monoatomic ion transmembrane transport [inference]

negative regulation of cation transmembrane transport [inference]

negative regulation of calcium ion transmembrane transport [inference]

negative regulation of calcium import into the mitochondrion

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
nucleus	HDA
mitochondrion	IDA
mitochondrion	IEA
mitochondrion	HTP
mitochondrion	HDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

mitochondrial permeability transition pore complex

mitochondrial protein-containing complex [inference]

mitochondrial permeability transition pore complex

cellular anatomical structure [inference]

nucleoid [inference]

mitochondrial nucleoid

plasma membrane

outer membrane [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

organelle membrane [inference]

mitochondrial membrane

mitochondrial outer membrane

bounding membrane of organelle [inference]

organelle outer membrane [inference]

mitochondrial outer membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular membraneless organelle [inference]

mitochondrial nucleoid

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
voltage-gated monoatomic ion channel activity	IDA
protein binding	IPI
ATP binding
oxysterol binding	ISS
oxysterol binding	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

monoatomic anion transmembrane transporter activity [inference]

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

monoatomic anion channel activity [inference]

voltage-gated monoatomic anion channel activity

wide pore channel activity [inference]

porin activity

gated channel activity [inference]

voltage-gated channel activity [inference]

voltage-gated monoatomic ion channel activity

voltage-gated monoatomic anion channel activity

binding [inference]

protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

lipid binding [inference]

steroid binding [inference]

sterol binding [inference]

phospholipid binding [inference]

phosphatidylcholine binding

sphingolipid binding [inference]

ceramide binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

cation binding [inference]

phosphatidylcholine binding

alcohol binding [inference]

cholesterol binding

quaternary ammonium group binding [inference]

phosphatidylcholine binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

voltage-dependent anion-selective channel

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
porin activity

Displaying **all 3** entries
InterPro
Eukaryotic porin/Tom40
Porin domain superfamily
Porin, eukaryotic type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:10283	prostate cancer	Alliance of Genome Resources

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Last updated: April 6, 2026