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SMC hinge domain containing 1

Summary

Gene Symbol

Smchd1

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

74355

KEGG Gene ID

PubChem

74355

Alliance of Genome Resources

MGI:1921605

Annotation

Keyword

3D-structure
Acetylation
Chromatin regulator
Chromosome
DNA repair
DNA-binding
Hydrolase
Isopeptide bond
Phosphoprotein
Reference proteome
Repressor
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
Q6P5D8

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
double-strand break repair	IEA
dosage compensation by inactivation of X chromosome	ISO
dosage compensation by inactivation of X chromosome	IEA
nose development	ISS
nose development	ISO

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

epigenetic programming of gene expression [inference]

genomic imprinting [inference]

inactivation of paternal X chromosome by genomic imprinting

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

heterochromatin organization [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

organelle organization [inference]

chromosome organization

cellular component assembly [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

sensory organ development [inference]

nose development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of response to stimulus [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of response to stimulus [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

epigenetic programming of gene expression [inference]

genomic imprinting [inference]

inactivation of paternal X chromosome by genomic imprinting

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

epigenetic regulation of gene expression [inference]

sex-chromosome dosage compensation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

epigenetic programming of gene expression [inference]

genomic imprinting [inference]

inactivation of paternal X chromosome by genomic imprinting

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic [inference]

heterochromatin formation [inference]

dosage compensation by inactivation of X chromosome

inactivation of paternal X chromosome by genomic imprinting

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of DNA recombination [inference]

negative regulation of double-strand break repair via homologous recombination

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

negative regulation of DNA repair [inference]

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of DNA repair

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

negative regulation of double-strand break repair via homologous recombination

negative regulation of double-strand break repair [inference]

negative regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via nonhomologous end joining

regulation of double-strand break repair via nonhomologous end joining [inference]

positive regulation of double-strand break repair via nonhomologous end joining

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	ISO
chromosome, telomeric region	IEA
Barr body	ISO
Barr body	IDA
Barr body	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

nucleoplasm

organelle [inference]

membraneless organelle [inference]

intracellular membraneless organelle [inference]

chromosome

nuclear chromosome [inference]

Barr body

sex chromosome [inference]

X chromosome [inference]

Barr body

nuclear body

intracellular organelle [inference]

intracellular membraneless organelle [inference]

chromosome

nuclear chromosome [inference]

Barr body

sex chromosome [inference]

X chromosome [inference]

Barr body

nuclear body

site of DNA damage [inference]

site of double-strand break

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
DNA binding
protein binding	IPI
ATP binding	IEA
ATP hydrolysis activity	ISO
ATP hydrolysis activity	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

binding [inference]

nucleic acid binding [inference]

DNA binding

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

structural maintenance of chromosomes flexible hinge domain-containing protein 1

Functional Category

G: Carbohydrate transport and metabolism
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
double-strand break repair

Displaying **all 4** entries
InterPro
Histidine kinase/HSP90-like ATPase superfamily
SMCs flexible hinge superfamily
SMCs flexible hinge
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Homo sapiens	23347	HGNC:29090

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements