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negative elongation factor complex member A

Summary

Gene Symbol

NELFA

Organism

Homo sapiens (human)

External Links

NCBI Gene

7469

PubChem

7469

Alliance of Genome Resources

HGNC:12768

JoGo

NELFA

TogoVar

NELFA

Annotation

Keyword

3D-structure
Alternative splicing
Direct protein sequencing
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repressor
Transcription regulation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H3P2	Wolf-Hirschhorn syndrome candidate 2 protein
A0A0C4DFX9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
negative regulation of transcription elongation by RNA polymerase II	IDA	12612062
negative regulation of transcription elongation by RNA polymerase II	IBA	http://purl.obolibrary.org/obo/go/references/0000033
positive regulation of transcription by RNA polymerase II	IEA	http://purl.obolibrary.org/obo/go/references/0000107
transcription pausing by RNA polymerase II	IDA	10199401

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

nucleic acid biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription pausing by RNA polymerase II

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

regulation of DNA-templated transcription elongation [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

regulation of transcription elongation by RNA polymerase II [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of DNA-templated transcription, elongation [inference]

negative regulation of transcription elongation by RNA polymerase II

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	11150502 12612062
nucleus	IEA	http://purl.obolibrary.org/obo/go/references/0000044 http://purl.obolibrary.org/obo/go/references/0000107
nucleoplasm	TAS	https://reactome.org/content/detail/R-HSA-112379 https://reactome.org/content/detail/R-HSA-112381 https://reactome.org/content/detail/R-HSA-112385 https://reactome.org/content/detail/R-HSA-112392 https://reactome.org/content/detail/R-HSA-112395 https://reactome.org/content/detail/R-HSA-112396 https://reactome.org/content/detail/R-HSA-112437 https://reactome.org/content/detail/R-HSA-113402 https://reactome.org/content/detail/R-HSA-113409 https://reactome.org/content/detail/R-HSA-113411 https://reactome.org/content/detail/R-HSA-113412 https://reactome.org/content/detail/R-HSA-113413 https://reactome.org/content/detail/R-HSA-113414 https://reactome.org/content/detail/R-HSA-113429 https://reactome.org/content/detail/R-HSA-170704 https://reactome.org/content/detail/R-HSA-170706 https://reactome.org/content/detail/R-HSA-6797606 https://reactome.org/content/detail/R-HSA-6797616
nucleoplasm	IDA	http://purl.obolibrary.org/obo/go/references/0000052
cytosol

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

transcription elongation factor complex [inference]

NELF complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin binding	IEA	http://purl.obolibrary.org/obo/go/references/0000107
protein binding	IPI	12612062 20211142 24981860 25416956 26496610 28298427 28514442 32296183 33961781 40205054
molecular adaptor activity	IDA	30135580
molecular adaptor activity	IBA	http://purl.obolibrary.org/obo/go/references/0000033
molecular adaptor activity	IPI	30135580