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Wnt family member 2

Summary

Gene Symbol

WNT2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7472

KEGG Gene ID

PubChem

7472

Alliance of Genome Resources

HGNC:12780

Annotation

Keyword

Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Proteomics identification
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A384MDX3
P09544	Int-1-like protein 1 Int-1-related protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **21 - 25** of 34 in total

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GO Term	Evidence Code	PMID
canonical Wnt signaling pathway	TAS
canonical Wnt signaling pathway	IDA
canonical Wnt signaling pathway	IMP
canonical Wnt signaling pathway	IBA
cardiac epithelial to mesenchymal transition

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

cell-cell signaling

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

canonical Wnt signaling pathway

cell population proliferation [inference]

mesenchymal cell proliferation

muscle cell proliferation [inference]

striated muscle cell proliferation [inference]

cardiac muscle cell proliferation

epithelial cell proliferation [inference]

epithelial cell proliferation involved in lung morphogenesis

neural precursor cell proliferation [inference]

cell proliferation in midbrain

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

neuron differentiation

central nervous system neuron differentiation [inference]

midbrain dopaminergic neuron differentiation

dopaminergic neuron differentiation [inference]

midbrain dopaminergic neuron differentiation

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

cell fate commitment

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

muscle tissue morphogenesis [inference]

cardiac muscle tissue morphogenesis [inference]

atrial cardiac muscle tissue morphogenesis

iris morphogenesis

developmental induction [inference]

organ induction [inference]

lung induction

anatomical structure development [inference]

blood vessel development [inference]

placenta blood vessel development [inference]

labyrinthine layer blood vessel development

lens development in camera-type eye

tissue development [inference]

epithelium development [inference]

mammary gland epithelium development

animal organ development

embryonic organ development [inference]

labyrinthine layer blood vessel development

system development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

neuron differentiation

central nervous system neuron differentiation [inference]

midbrain dopaminergic neuron differentiation

dopaminergic neuron differentiation [inference]

midbrain dopaminergic neuron differentiation

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition [inference]

cardiac epithelial to mesenchymal transition

cell fate commitment

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to transforming growth factor beta [inference]

cellular response to transforming growth factor beta stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to transforming growth factor beta stimulus

response to chemical [inference]

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of growth [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of biological process [inference]

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in lung morphogenesis

positive regulation of cardiac muscle cell proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of morphogenesis of an epithelium [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of animal organ morphogenesis [inference]

regulation of animal organ formation [inference]

organ induction [inference]

lung induction

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

regulation of developmental growth [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

positive regulation of developmental growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

canonical Wnt signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in lung morphogenesis

positive regulation of cardiac muscle cell proliferation

regulation of mesenchymal cell proliferation [inference]

positive regulation of mesenchymal cell proliferation

regulation of fibroblast proliferation [inference]

positive regulation of fibroblast proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in lung morphogenesis

regulation of epithelial cell proliferation involved in lung morphogenesis [inference]

positive regulation of epithelial cell proliferation involved in lung morphogenesis

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation involved in lung morphogenesis

positive regulation of cardiac muscle cell proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis

regulation of multicellular organismal process [inference]

regulation of organ growth [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of organ growth [inference]

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

positive regulation of animal organ morphogenesis [inference]

organ induction [inference]

lung induction

regulation of morphogenesis of a branching structure [inference]

regulation of branching involved in lung morphogenesis [inference]

lung induction

regulation of multicellular organismal development [inference]

regulation of embryonic development [inference]

lung induction

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis

regulation of heart growth [inference]

regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

regulation of cardiac muscle cell proliferation [inference]

positive regulation of cardiac muscle cell proliferation

positive regulation of heart growth [inference]

positive regulation of cardiac muscle tissue growth [inference]

positive regulation of cardiac muscle cell proliferation

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
extracellular region	EXP
extracellular region	NAS
extracellular region	TAS
extracellular region	IDA
extracellular region	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

Wnt signalosome

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IEA
frizzled binding	IBA
frizzled binding	IPI
cytokine activity	IDA
cytokine activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

frizzled binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:3996	urinary system cancer	Alliance of Genome Resources
DOID:3459	breast carcinoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22413	MGI:98954
Danio rerio	30127	ZFIN:ZDB-GENE-980526-416

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

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Acknowledgements