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Wnt family member 11

Summary

Gene Symbol

WNT11

Organism

Homo sapiens (human)

External Links

NCBI Gene

7481

KEGG Gene ID

PubChem

7481

Alliance of Genome Resources

HGNC:12776

Annotation

Keyword

Developmental protein
Disulfide bond
Extracellular matrix
Glycoprotein
Lipoprotein
Proteomics identification
Reference proteome
Signal
Wnt signaling pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
M4IS22
O96014

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 49 in total

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GO Term	Evidence Code	PMID
osteoblast differentiation
epithelial to mesenchymal transition
primary heart field specification	IEA
secondary heart field specification	IEA
outflow tract morphogenesis

GO Hierarchy

biological process

cellular process [inference]

establishment or maintenance of cell polarity [inference]

maintenance of cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of bipolar cell polarity [inference]

establishment or maintenance of apical/basal cell polarity [inference]

maintenance of apical/basal cell polarity [inference]

maintenance of epithelial cell apical/basal polarity

establishment or maintenance of epithelial cell apical/basal polarity [inference]

maintenance of epithelial cell apical/basal polarity

signal transduction

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

non-canonical Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process

cell population proliferation [inference]

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

neuron differentiation

neuroendocrine cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

neuroendocrine cell differentiation

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell fate commitment

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

tight junction assembly [inference]

bicellular tight junction assembly

tight junction organization [inference]

tight junction assembly [inference]

bicellular tight junction assembly

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

specification of animal organ identity [inference]

heart field specification [inference]

developmental process [inference]

anatomical structure morphogenesis [inference]

outflow tract morphogenesis

animal organ morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

artery morphogenesis

cloacal septation

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

embryonic morphogenesis [inference]

embryonic organ morphogenesis [inference]

notochord morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

convergent extension [inference]

convergent extension involved in axis elongation

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

nephron epithelium morphogenesis [inference]

nephron tubule morphogenesis [inference]

mesonephric tubule morphogenesis [inference]

ureteric bud morphogenesis

cardiac septum morphogenesis [inference]

ventricular septum morphogenesis

anatomical structure formation involved in morphogenesis [inference]

formation of primary germ layer [inference]

mesoderm formation [inference]

paraxial mesoderm formation

anatomical structure development [inference]

cardiac septum development [inference]

tissue development [inference]

biomineral tissue development [inference]

bone mineralization

epithelium development [inference]

somite development

kidney epithelium development [inference]

mesonephric epithelium development [inference]

mesonephric tubule development [inference]

mesonephric duct development

nephric duct development [inference]

mesonephric duct development

mesenchyme development [inference]

lung-associated mesenchyme development

tube development [inference]

mesonephric tubule development [inference]

mesonephric duct development

nephric duct development [inference]

mesonephric duct development

animal organ development [inference]

gland development [inference]

adrenal gland development

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

roof of mouth development [inference]

secondary palate development

cellular developmental process [inference]

cell differentiation

osteoblast differentiation

neuron differentiation

neuroendocrine cell differentiation

epithelial cell differentiation [inference]

columnar/cuboidal epithelial cell differentiation [inference]

neuroepithelial cell differentiation [inference]

neuroendocrine cell differentiation

mesenchymal cell differentiation [inference]

epithelial to mesenchymal transition

cell fate commitment

response to stimulus [inference]

response to external stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to external stimulus [inference]

cellular response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus [inference]

cellular response to mechanical stimulus

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

response to nutrient levels

response to chemical [inference]

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to mechanical stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of developmental process [inference]

negative regulation of cartilage development

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of cartilage development

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of developmental process [inference]

negative regulation of developmental process [inference]

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

regulation of cellular process [inference]

signal transduction

cell surface receptor signaling pathway [inference]

Wnt signaling pathway

non-canonical Wnt signaling pathway [inference]

canonical Wnt signaling pathway

intracellular signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta2 production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of fibroblast growth factor production [inference]

negative regulation of fibroblast growth factor production

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta2 production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of fibroblast growth factor production [inference]

negative regulation of fibroblast growth factor production

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation [inference]

regulation of mesenchymal cell proliferation [inference]

negative regulation of mesenchymal cell proliferation

regulation of stem cell proliferation [inference]

negative regulation of stem cell proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process

regulation of epithelial cell apoptotic process [inference]

positive regulation of epithelial cell apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process [inference]

positive regulation of epithelial cell apoptotic process

negative regulation of cellular process [inference]

negative regulation of cell population proliferation [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Wnt signaling pathway [inference]

negative regulation of canonical Wnt signaling pathway

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta2 production [inference]

positive regulation of transforming growth factor beta2 production

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

regulation of fibroblast growth factor production [inference]

negative regulation of fibroblast growth factor production

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production [inference]

positive regulation of transforming growth factor beta production [inference]

positive regulation of transforming growth factor beta2 production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of fibroblast growth factor production

negative regulation of cartilage development

regulation of multicellular organismal development [inference]

regulation of cartilage development [inference]

negative regulation of cartilage development

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
extracellular region	TAS
extracellular region	IBA
extracellular region	IEA
obsolete extracellular space
cytoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

external encapsulating structure [inference]

extracellular matrix

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
signaling receptor binding	IEA
frizzled binding	NAS
frizzled binding	IBA
cytokine activity	IBA
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding

G protein-coupled receptor binding [inference]

frizzled binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

kinase regulator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

protein kinase regulator activity [inference]

protein kinase activator activity

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

molecular function activator activity [inference]

enzyme activator activity [inference]

kinase activator activity [inference]

protein kinase activator activity

signaling receptor activator activity [inference]

receptor ligand activity [inference]

cytokine activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0050866	oral squamous cell carcinoma	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	22411	MGI:101948
Caenorhabditis elegans	171994	WB:WBGene00003029
Xenopus laevis	446915	Xenbase:XB-GENE-866540
Xenopus tropicalis	100158655	Xenbase:XB-GENE-854158

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

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Summary

External Links

Annotation

International Collaboration

Acknowledgements