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exportin 1

Summary

Gene Symbol

XPO1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7514

KEGG Gene ID

PubChem

7514

Alliance of Genome Resources

HGNC:12825

Annotation

Keyword

3D-structure
Acetylation
Cytoplasm
Direct protein sequencing
Host-virus interaction
Nucleus
Phosphoprotein
Protein transport
Proteomics identification
RNA-binding
Reference proteome
Repeat
mRNA transport

Proteins

Displaying **all 5** entries
UniProt	Protein Name
O14980	Chromosome region maintenance 1 protein homolog
A0A7I2V2Y6	Chromosome region maintenance 1 protein homolog
A0A7I2V6B9	Chromosome region maintenance 1 protein homolog
A0A7I2V461	Chromosome region maintenance 1 protein homolog
B3KWD0	Chromosome region maintenance 1 protein homolog

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 24 in total

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GO Term	Evidence Code	PMID
ribosomal subunit export from nucleus	IMP
ribosomal large subunit export from nucleus	IMP
ribosomal large subunit export from nucleus	IBA
ribosomal small subunit export from nucleus	IMP
ribosomal small subunit export from nucleus	IBA

GO Hierarchy

biological process

cellular process [inference]

intercellular transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to triglyceride

cellular response to oxygen-containing compound [inference]

cellular response to triglyceride

cellular response to salt

cellular component organization or biogenesis [inference]

cellular component biogenesis [inference]

ribonucleoprotein complex biogenesis [inference]

ribosome biogenesis

response to stimulus [inference]

response to chemical [inference]

response to xenobiotic stimulus

response to lipid [inference]

response to triglyceride [inference]

cellular response to triglyceride

cellular response to lipid [inference]

cellular response to triglyceride

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to triglyceride

cellular response to oxygen-containing compound [inference]

cellular response to triglyceride

cellular response to salt

response to oxygen-containing compound [inference]

response to triglyceride [inference]

cellular response to triglyceride

cellular response to oxygen-containing compound [inference]

cellular response to triglyceride

response to salt [inference]

cellular response to salt

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to triglyceride

cellular response to oxygen-containing compound [inference]

cellular response to triglyceride

cellular response to salt

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

protein localization to organelle [inference]

protein localization to nucleus

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

protein transport [inference]

intracellular protein transport

protein export from nucleus

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

nitrogen compound transport [inference]

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport

mRNA export from nucleus

establishment of protein localization [inference]

protein transport [inference]

intracellular protein transport

protein export from nucleus

establishment of RNA localization [inference]

RNA transport [inference]

RNA export from nucleus [inference]

mRNA export from nucleus

mRNA transport

mRNA export from nucleus

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

organelle localization [inference]

ribosome localization [inference]

ribosomal subunit export from nucleus

establishment of organelle localization [inference]

ribosomal subunit export from nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport

protein export from nucleus

nuclear transport [inference]

nucleocytoplasmic transport

nuclear export [inference]

ribosomal subunit export from nucleus

RNA export from nucleus [inference]

mRNA export from nucleus

protein export from nucleus

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of catabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

regulation of proteasomal protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of ubiquitin-dependent protein catabolic process [inference]

regulation of proteasomal ubiquitin-dependent protein catabolic process

regulation of microtubule-based process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription [inference]

negative regulation of transcription by RNA polymerase II

regulation of cellular component organization [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of centrosome cycle [inference]

regulation of centrosome duplication

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein export from nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein export from nucleus

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
kinetochore	IDA
nucleus	IBA
nucleus	IEA
nuclear envelope	TAS
annulate lamellae	IDA

GO Hierarchy

cellular component

protein-containing complex

ribonucleoprotein complex

cellular anatomical structure [inference]

membrane

annulate lamellae

organelle membrane [inference]

nuclear membrane

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nuclear body [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

supramolecular complex [inference]

kinetochore

ribonucleoprotein granule [inference]

nuclear ribonucleoprotein granule [inference]

Cajal body

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
RNA binding
nuclear export signal receptor activity	ISS
nuclear export signal receptor activity	TAS
nuclear export signal receptor activity	IDA
nuclear export signal receptor activity	IMP

GO Hierarchy

molecular function

binding [inference]

nucleic acid binding [inference]

RNA binding

protein binding

transcription factor binding [inference]

DNA-binding transcription factor binding

enzyme binding [inference]

GTPase binding [inference]

small GTPase binding

protein domain specific binding

molecular carrier activity [inference]

nucleocytoplasmic carrier activity [inference]

nuclear export signal receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

exportin

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 9** entries
InterPro
Armadillo-like helical
Armadillo-type fold
Chromosome region maintenance repeat
Exportin-1, C-terminal
Exportin-1, repeat 2
Exportin-1, repeat 3
Exportin-1/5
Exportin-1/Importin-beta-like
Importin-beta, N-terminal domain

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources
DOID:3717	gastric adenocarcinoma	Alliance of Genome Resources

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements