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Guidelines

MIRAGE

X-ray repair cross complementing 1

Summary

Gene Symbol

XRCC1

Organism

Homo sapiens (human)

External Links

NCBI Gene

7515

KEGG Gene ID

PubChem

7515

Alliance of Genome Resources

HGNC:12828

Annotation

Keyword

3D-structure
Chromosome
DNA repair
Isopeptide bond
Neurodegeneration
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Repeat
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P18887	X-ray repair cross-complementing protein 1
B2RCY5	X-ray repair cross-complementing protein 1
Q59HH7	X-ray repair cross-complementing protein 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
single strand break repair	IMP
single strand break repair	IEA
regulation of DNA repair	NAS
base-excision repair	IDA
base-excision repair	IBA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

double-strand break repair

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

DNA repair [inference]

double-strand break repair

double-strand break repair via nonhomologous end joining

DNA recombination [inference]

mitotic recombination [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

double-strand break repair via nonhomologous end joining

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

chromosome organization [inference]

telomere organization [inference]

telomere maintenance [inference]

telomere maintenance via recombination [inference]

telomeric DNA-containing double minutes formation

developmental process [inference]

anatomical structure development [inference]

hippocampus development

response to stimulus [inference]

response to stress [inference]

response to oxidative stress [inference]

response to hydroperoxide

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

double-strand break repair via nonhomologous end joining

response to chemical [inference]

response to oxygen-containing compound [inference]

response to hydroperoxide

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

double-strand break repair

double-strand break repair via nonhomologous end joining

biological regulation [inference]

regulation of biological process [inference]

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of response to stimulus [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of response to stimulus [inference]

negative regulation of response to stimulus [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair

regulation of base-excision repair

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of base-excision repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of base-excision repair

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of DNA metabolic process [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of chromosome organization [inference]

regulation of telomere maintenance [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere capping [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of cellular component organization [inference]

negative regulation of organelle organization [inference]

negative regulation of chromosome organization [inference]

negative regulation of telomere maintenance [inference]

negative regulation of telomere capping [inference]

negative regulation of protection from non-homologous end joining at telomere

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of cellular response to stress [inference]

regulation of DNA repair

regulation of base-excision repair

regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of telomere maintenance in response to DNA damage [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of protection from non-homologous end joining at telomere [inference]

negative regulation of protection from non-homologous end joining at telomere

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of protein ADP-ribosylation

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of protein ADP-ribosylation

regulation of transferase activity [inference]

regulation of protein ADP-ribosylation [inference]

negative regulation of protein ADP-ribosylation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IEA
chromatin	IDA
nucleus	EXP
nucleus	NAS
nucleus	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nucleotide-excision repair complex [inference]

ERCC4-ERCC1 complex

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

site of DNA damage

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
damaged DNA binding	IEA
protein binding	IPI
enzyme binding	IPI
oxidized DNA binding	IMP
poly-ADP-D-ribose binding	IDA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

single-stranded DNA endonuclease activity [inference]

3' overhang single-stranded DNA endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

nuclease activity [inference]

endonuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endonuclease activity [inference]

3' overhang single-stranded DNA endonuclease activity

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endonuclease activity [inference]

3' overhang single-stranded DNA endonuclease activity

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA endonuclease activity [inference]

single-stranded DNA endonuclease activity [inference]

3' overhang single-stranded DNA endonuclease activity

binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

protein binding

enzyme binding

modification-dependent protein binding [inference]

ADP-D-ribose modification-dependent protein binding

carbohydrate derivative binding [inference]

poly-ADP-D-ribose binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying entries **1 - 10** of 47 in total

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DO ID	Disease Name	Source
DOID:2773	contact dermatitis	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources
DOID:9669	senile cataract	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:2600	laryngeal carcinoma	Alliance of Genome Resources
DOID:127	leiomyoma	Alliance of Genome Resources
DOID:684	hepatocellular carcinoma	Alliance of Genome Resources
DOID:5041	esophageal cancer	Alliance of Genome Resources
DOID:11054	urinary bladder cancer	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources

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Last updated: April 6, 2026