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Guidelines

MIRAGE

phosphoinositide-3-kinase regulatory subunit 4

Summary

Gene Symbol

Pik3r4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

75669

PubChem

75669

Alliance of Genome Resources

MGI:1922919

Annotation

Keyword

ATP-binding
Cytoplasmic vesicle
Endosome
Membrane
Myristate
Phosphoprotein
Reference proteome
Repeat
Serine/threonine-protein kinase
WD repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q8VD65

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 23 in total

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GO Term	Evidence Code	PMID
pexophagy	IBA
protein targeting to lysosome	NAS	16467569
protein targeting to vacuole	IBA
regulation of autophagy	ISO
regulation of autophagy	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

catabolic process [inference]

autophagy [inference]

pexophagy

autophagy of peroxisome [inference]

pexophagy

macromolecule catabolic process [inference]

receptor catabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

macromolecule metabolic process [inference]

macromolecule catabolic process [inference]

receptor catabolic process

receptor metabolic process [inference]

receptor catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process [inference]

phosphatidylinositol-3-phosphate biosynthetic process

intercellular transport [inference]

late endosome to vacuole transport

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

late endosome to vacuole transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

process utilizing autophagic mechanism [inference]

autophagy [inference]

pexophagy

autophagy of peroxisome [inference]

pexophagy

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component disassembly [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

protein-containing complex organization [inference]

protein-containing complex disassembly [inference]

autophagosome maturation

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to nutrient levels [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

response to starvation [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stimulus [inference]

cellular response to nutrient levels [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

cellular response to stress [inference]

cellular response to starvation [inference]

cellular response to glucose starvation

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

protein localization to organelle [inference]

protein localization to vacuole [inference]

protein targeting to vacuole

protein targeting to lysosome

protein localization to lysosome [inference]

protein targeting to lysosome

establishment of localization [inference]

transport [inference]

intercellular transport [inference]

late endosome to vacuole transport

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vesicle-mediated transport [inference]

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

late endosome to vacuole transport

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

establishment of protein localization [inference]

protein targeting [inference]

protein targeting to vacuole

protein targeting to lysosome

protein transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

establishment of protein localization to organelle [inference]

establishment of protein localization to vacuole [inference]

protein targeting to vacuole

protein targeting to lysosome

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein targeting to vacuole

protein targeting to lysosome

vacuolar transport [inference]

protein targeting to vacuole

protein targeting to lysosome

lysosomal transport [inference]

protein targeting to lysosome

late endosome to vacuole transport

endosomal transport [inference]

vesicle-mediated transport between endosomal compartments [inference]

early endosome to late endosome transport

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

intracellular signaling cassette [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of metabolic process [inference]

regulation of catabolic process [inference]

regulation of autophagy

regulation of macroautophagy

regulation of cell division [inference]

regulation of cytokinesis

regulation of cell cycle [inference]

regulation of cell cycle process [inference]

regulation of cytokinesis

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
cytoplasm	IEA
late endosome	ISS
late endosome	ISO
late endosome	IBA
late endosome	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class III

cellular anatomical structure [inference]

cytoplasm

microtubule organizing center [inference]

ciliary basal body

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

organelle [inference]

membrane-bounded organelle [inference]

cilium

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

microtubule cytoskeleton

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

autophagosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

intracellular membraneless organelle [inference]

microtubule cytoskeleton

organelle membrane contact site [inference]

nucleus-vacuole junction

intercellular bridge

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein kinase activity	IEA
protein serine/threonine kinase activity	IBA
protein serine/threonine kinase activity	IEA
protein binding	IPI	24705551 34428398
ATP binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphoinositide 3-kinase regulatory subunit 4

Functional Category

C: Energy production and conversion
E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism

Displaying **all 6** entries
Gene Ontology
ATP binding
kinase activity
late endosome to vacuole transport
phosphorylation
protein targeting to vacuole
transferase activity

Displaying **all 10** entries
InterPro
Armadillo-like helical
Armadillo-type fold
HEAT, type 2
Protein kinase domain
Protein kinase-like domain superfamily
Serine/threonine-protein kinase Vps15-like
Serine/threonine-protein kinase, active site
WD40 repeat
WD40-repeat-containing domain superfamily
WD40/YVTN repeat-like-containing domain superfamily

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026