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BTG anti-proliferation factor 2

Summary

Gene Symbol

BTG2

Organism

Homo sapiens (human)

External Links

NCBI Gene

7832

KEGG Gene ID

PubChem

7832

Alliance of Genome Resources

HGNC:1131

Annotation

Keyword

3D-structure
Phosphoprotein
Proteomics identification
Reference proteome
Transcription regulation

Proteins

Displaying 1 entry
UniProt	Protein Name
P78543	BTG family member 2 NGF-inducible anti-proliferative protein PC3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
negative regulation of transcription by RNA polymerase II
DNA repair	TAS
cellular response to DNA damage stimulus	IDA
DNA damage response	IDA
neuroblast proliferation

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair

cell population proliferation [inference]

neural precursor cell proliferation [inference]

neuroblast proliferation

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning

developmental process [inference]

anatomical structure development [inference]

dentate gyrus development

cell development [inference]

neuron development [inference]

central nervous system neuron development

cellular developmental process [inference]

cell differentiation [inference]

skeletal muscle cell differentiation

cell development [inference]

neuron development [inference]

central nervous system neuron development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to endogenous stimulus [inference]

response to hormone [inference]

response to peptide hormone

response to chemical [inference]

response to hormone [inference]

response to peptide hormone

response to lipid [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to nitrogen compound [inference]

response to peptide hormone

response to oxygen-containing compound [inference]

response to peptide hormone

response to alcohol [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

response to ketone [inference]

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

response to phorbol 13-acetate 12-myristate [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to stimulus [inference]

cellular response to stress [inference]

cellular response to DNA damage stimulus

DNA repair

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to oxygen-containing compound [inference]

cellular response to alcohol [inference]

cellular response to phorbol 13-acetate 12-myristate

cellular response to ketone [inference]

cellular response to phorbol 13-acetate 12-myristate

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of neural precursor cell proliferation [inference]

negative regulation of neuroblast proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of cellular process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA poly(A) tail shortening [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA poly(A) tail shortening [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

post-transcriptional regulation of gene expression [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of gene expression [inference]

negative regulation of translation

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA poly(A) tail shortening [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA poly(A) tail shortening [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of mRNA metabolic process [inference]

regulation of mRNA catabolic process [inference]

regulation of nuclear-transcribed mRNA poly(A) tail shortening [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

negative regulation of transcription by RNA polymerase II

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

regulation of protein metabolic process [inference]

regulation of translation [inference]

negative regulation of translation

negative regulation of protein metabolic process [inference]

negative regulation of translation

regulation of cell population proliferation [inference]

negative regulation of cell population proliferation

negative regulation of neural precursor cell proliferation [inference]

negative regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

negative regulation of neuroblast proliferation

negative regulation of neural precursor cell proliferation [inference]

negative regulation of neuroblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of cell development [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

positive regulation of macromolecule metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of mRNA metabolic process [inference]

positive regulation of mRNA catabolic process [inference]

positive regulation of nuclear-transcribed mRNA poly(A) tail shortening

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of neural precursor cell proliferation [inference]

negative regulation of neuroblast proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of translation

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of protein metabolic process [inference]

negative regulation of translation

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of nucleobase-containing compound metabolic process [inference]

negative regulation of RNA metabolic process [inference]

negative regulation of RNA biosynthetic process [inference]

negative regulation of DNA-templated transcription

negative regulation of transcription by RNA polymerase II

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of neuron apoptotic process

negative regulation of cell differentiation [inference]

negative regulation of cell development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of multicellular organismal process [inference]

negative regulation of multicellular organismal process [inference]

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

negative regulation of nervous system development [inference]

negative regulation of neurogenesis [inference]

negative regulation of neuroblast proliferation

Displaying **all 4** entries
GO Term	Evidence Code	PMID
nucleus	IBA
cytoplasm	IBA
cytosol	TAS
extracellular exosome	HDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

nucleus

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
transcription corepressor activity	IEA
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription regulator activity [inference]

transcription coregulator activity [inference]

transcription corepressor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Tob1

Functional Category

E: Amino acid transport and metabolism
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
negative regulation of cell population proliferation
negative regulation of mitotic cell cycle

Displaying **all 3** entries
InterPro
Anti-proliferative protein
BTG family
BTG-like domain superfamily

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements