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mannosyl-oligosaccharide glucosidase

Summary

Gene Symbol

MOGS

Aliases

CWH41
DER7
GCS1
glucosidase I
processing A-glucosidase I

Organism

Homo sapiens (human)

External Links

NCBI Gene

7841

HGNC

24862

KEGG Gene ID

hsa:7841

PubChem

7841

Alliance of Genome Resources

HGNC:24862

JoGo

MOGS

TogoVar

MOGS

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Glycosidase
Proteomics identification
Reference proteome
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A0A384MDR6	Glucosidase I
Q58F09	Glucosidase I
Q13724	Processing A-glucosidase I

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
carbohydrate metabolic process	IEA
protein folding	TAS
protein N-linked glycosylation	TAS
protein N-linked glycosylation	IBA
protein N-linked glycosylation	IEA

GO Hierarchy

biological process

cellular process [inference]

protein folding

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

carbohydrate metabolic process

oligosaccharide metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

viral process [inference]

viral protein processing

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GO Term	Evidence Code	PMID
endoplasmic reticulum	TAS
endoplasmic reticulum	IDA
endoplasmic reticulum	IEA
endoplasmic reticulum membrane	EXP
endoplasmic reticulum membrane	TAS

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

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GO Term	Evidence Code	PMID
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	EXP
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	TAS
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IBA
Glc3Man9GlcNAc2 oligosaccharide glucosidase activity	IEA
glucosidase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

glucosidase activity

alpha-glucosidase activity [inference]

Glc3Man9GlcNAc2 oligosaccharide glucosidase activity

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000115275

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K01228

Name

mannosyl-oligosaccharide glucosidase [EC:3.2.1.106]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R05979	3.2.1.106	G57930PW	G18948TG

Rhea

RHEA:55988

H₂O

β-D-glucose

Enzyme

3.2.1.106

PMID

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0070254	congenital disorder of glycosylation type IIb	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000034	Hydrocele testis
HP:0000218	High palate
HP:0000269	Prominent occiput
HP:0000278	Retrognathia
HP:0000407	Sensorineural hearing impairment
HP:0000445	Wide nose
HP:0000527	Long eyelashes
HP:0000581	Blepharophimosis
HP:0000648	Optic atrophy

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:79330	MOGS-congenital disorder of glycosylation
OMIM:606056	MOGS-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

MOGS-congenital disorder of glycosylation

OMIM Phenotypes

CONGENITAL DISORDER OF GLYCOSYLATION, TYPE IIb; CDG2B

KEGG Diseases

Congenital disorders of glycosylation type II

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	57377	MGI:1929872
Rattus norvegicus	78947	RGD:69240
Caenorhabditis elegans	177998	WB:WBGene00008775
Saccharomyces cerevisiae S288C	852857	SGD:S000002995

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements