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MIRAGE
C-X-C motif chemokine receptor 4
Summary
- Gene Symbol
-
- CXCR4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Alternative splicing
- Cell junction
- Cell membrane
- Disease variant
- Disulfide bond
- Endosome
- G-protein coupled receptor
- Host cell receptor for virus entry
- Host-virus interaction
- Isopeptide bond
- Lysosome
- Phosphoprotein
- Proteoglycan
- Proteomics identification
- Reference proteome
- Sulfation
- Transmembrane helix
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A0U3FJG0 |
|
| A0A8Q3WLL1 |
|
| P61073 |
|
| A0A0U3GXA9 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| response to hypoxia |
|
|
| dendritic cell chemotaxis |
|
|
| apoptotic process |
|
|
| chemotaxis |
|
|
| inflammatory response |
|
GO Hierarchy
biological process
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of developmental process [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytoplasm |
|
|
| lysosome |
|
|
| lysosome |
|
|
| early endosome |
|
|
| early endosome |
|
| GO Term | Evidence Code | PMID |
|---|---|---|
| virus receptor activity |
|
|
| actin binding |
|
|
| G protein-coupled receptor activity |
|
|
| G protein-coupled receptor activity |
|
|
| chemokine receptor activity |
|
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- C-X-C chemokine receptor type 4-A
- Functional Category
-
- E: Amino acid transport and metabolism
- G: Carbohydrate transport and metabolism
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| C-C chemokine binding |
| C-C chemokine receptor activity |
| brain development |
| calcium-mediated signaling |
| cell chemotaxis |
| chemokine receptor activity |
| chemokine-mediated signaling pathway |
| chemotaxis |
| immune response |
| neurogenesis |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060591 | WHIM syndrome 1 | |
| DOID:0060901 | lymphoplasmacytic lymphoma | |
| DOID:10283 | prostate cancer | |
| DOID:10534 | stomach cancer | |
| DOID:11476 | osteoporosis | |
| DOID:3347 | osteosarcoma | |
| DOID:4074 | pancreatic adenocarcinoma | |
| DOID:5603 | T-cell acute lymphoblastic leukemia | |
| DOID:615 | leukopenia | |
| DOID:9119 | acute myeloid leukemia |
