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C-X-C motif chemokine receptor 4

Summary

Gene Symbol

CXCR4

Organism

Homo sapiens (human)

External Links

NCBI Gene

7852

PubChem

7852

Alliance of Genome Resources

HGNC:2561

Annotation

Keyword

3D-structure
Alternative splicing
Cell junction
Cell membrane
Disease variant
Disulfide bond
Endosome
G-protein coupled receptor
Host cell receptor for virus entry
Host-virus interaction
Isopeptide bond
Lysosome
Phosphoprotein
Proteoglycan
Proteomics identification
Reference proteome
Sulfation
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0U3FJG0
A0A0U3GXA9
A0A8Q3WLL1
P61073	FB22 Fusin HM89 LCR1 Leukocyte-derived seven transmembrane domain receptor Lipopolysaccharide-associated protein 3 NPYRL Stromal cell-derived factor 1 receptor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 46 in total

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GO Term	Evidence Code	PMID
response to hypoxia	IEP	15174142
neuron migration	IEA
epithelial cell development	IEA
dendritic cell chemotaxis	TAS	16621978
apoptotic process	TAS	10942389

GO Hierarchy

biological process

immune system process [inference]

immune response

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

cell recognition [inference]

neuron recognition

cell death [inference]

programmed cell death [inference]

apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

epithelial cell differentiation [inference]

endothelial cell differentiation

cell development [inference]

epithelial cell development

cell motility [inference]

cell migration [inference]

neuron migration

forebrain cell migration [inference]

telencephalon cell migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

cell chemotaxis

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to xenobiotic stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

myelin maintenance

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

cardiac muscle contraction

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

endothelial tube morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of an endothelium [inference]

endothelial tube morphogenesis

epithelial tube morphogenesis [inference]

endothelial tube morphogenesis

anatomical structure development [inference]

cell development [inference]

epithelial cell development

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

epithelial cell differentiation [inference]

endothelial cell differentiation

cell development [inference]

epithelial cell development

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with host [inference]

movement in host [inference]

entry into host [inference]

viral entry into host cell

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

response to hypoxia

defense response [inference]

inflammatory response

immune response

response to external stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to ultrasound

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to temperature stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to mechanical stimulus [inference]

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

response to ultrasound

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to activity

response to chemical [inference]

response to xenobiotic stimulus [inference]

cellular response to xenobiotic stimulus

response to organic substance [inference]

response to organonitrogen compound [inference]

response to tacrolimus

response to organic cyclic compound [inference]

response to tacrolimus

response to cytokine [inference]

cellular response to cytokine stimulus

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to xenobiotic stimulus

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to tacrolimus

response to oxygen-containing compound [inference]

response to tacrolimus

detection of stimulus [inference]

detection of external stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of abiotic stimulus [inference]

detection of temperature stimulus [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus [inference]

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception [inference]

detection of temperature stimulus involved in sensory perception of pain

detection of mechanical stimulus involved in sensory perception [inference]

detection of mechanical stimulus involved in sensory perception of pain

detection of stimulus involved in sensory perception of pain [inference]

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus

cellular response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport

regulation of growth [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

regulation of chemotaxis

positive regulation of chemotaxis

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

regulation of mesenchymal stem cell migration [inference]

positive regulation of mesenchymal stem cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of cold-induced thermogenesis

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of locomotion [inference]

positive regulation of chemotaxis

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

positive regulation of growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of vascular wound healing

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cold-induced thermogenesis

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

regulation of chemotaxis

positive regulation of chemotaxis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to external stimulus [inference]

positive regulation of chemotaxis

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of vascular wound healing

regulation of response to cytokine stimulus [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of response to cytokine stimulus [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of response to stress [inference]

regulation of response to wounding [inference]

regulation of wound healing [inference]

regulation of vascular wound healing [inference]

positive regulation of vascular wound healing

positive regulation of wound healing [inference]

positive regulation of vascular wound healing

positive regulation of response to wounding [inference]

positive regulation of wound healing [inference]

positive regulation of vascular wound healing

regulation of viral process

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of vascular wound healing [inference]

positive regulation of vascular wound healing

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of glial cell differentiation [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of oligodendrocyte differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of developmental growth [inference]

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of developmental growth [inference]

positive regulation of dendrite extension

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of vascular wound healing [inference]

positive regulation of vascular wound healing

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

cytokine-mediated signaling pathway [inference]

chemokine-mediated signaling pathway [inference]

chemokine (C-X-C motif) ligand 12 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

C-X-C chemokine receptor CXCR4 signaling pathway [inference]

CXCL12-activated CXCR4 signaling pathway

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

second-messenger-mediated signaling [inference]

calcium-mediated signaling

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of cytokine-mediated signaling pathway [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of macrophage migration inhibitory factor signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of glial cell differentiation [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of oligodendrocyte differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of cytokine-mediated signaling pathway [inference]

positive regulation of macrophage migration inhibitory factor signaling pathway

positive regulation of cell growth [inference]

positive regulation of dendrite extension

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cell growth [inference]

positive regulation of dendrite extension

regulation of dendrite extension [inference]

positive regulation of dendrite extension

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

regulation of mesenchymal stem cell migration [inference]

positive regulation of mesenchymal stem cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of mesenchymal stem cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of cold-induced thermogenesis

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of cold-induced thermogenesis [inference]

positive regulation of cold-induced thermogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

regulation of gliogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of gliogenesis [inference]

positive regulation of glial cell differentiation [inference]

positive regulation of oligodendrocyte differentiation

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of vascular wound healing [inference]

positive regulation of vascular wound healing

positive regulation of vasculature development

positive regulation of angiogenesis [inference]

positive regulation of vascular wound healing

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

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GO Term	Evidence Code	PMID
cytoplasm	TAS	10415069
lysosome	IDA	21540189 24790097
early endosome	IDA	21540189 24790097
late endosome	IDA	21540189
plasma membrane	TAS

GO Hierarchy

cellular component

protein-containing complex

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

anchoring junction

cell leading edge

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

endosome [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

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GO Term	Evidence Code	PMID
virus receptor activity	IEA
actin binding	IDA	12421915
G protein-coupled receptor activity	TAS	8276799
protein binding	IPI	10644702 12421915 15660419 17077324 18632580 18765807 19106094 19380869 19665027 20215400 20802527 21730065 23170857 23773523 23926103 24094005 25775528 27331810 28862946 28978524 29386406 34927784
coreceptor activity	TAS	10754293

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding [inference]

actin binding

myosin binding [inference]

myosin light chain binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

cytokine binding [inference]

chemokine binding [inference]

C-C chemokine binding

ubiquitin-like protein binding [inference]

ubiquitin binding

exogenous protein binding [inference]

virus receptor activity

small molecule binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

C-X-C motif chemokine 12 receptor activity

G protein-coupled receptor activity

G protein-coupled chemoattractant receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

C-X-C motif chemokine 12 receptor activity

coreceptor activity

immune receptor activity [inference]

cytokine receptor activity [inference]

chemokine receptor activity [inference]

C-C chemokine receptor activity

C-X-C chemokine receptor activity

C-X-C motif chemokine 12 receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

receptor

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

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Gene Ontology
C-C chemokine binding
C-C chemokine receptor activity
brain development
calcium-mediated signaling
cell chemotaxis
chemokine receptor activity
chemokine-mediated signaling pathway
chemotaxis
immune response
neurogenesis

Displaying **all 4** entries
InterPro
CXC chemokine receptor 4/atypical chemokine receptor 2
Chemokine receptor family
G protein-coupled receptor, rhodopsin-like
GPCR, rhodopsin-like, 7TM

Disease

Disease Ontology

Displaying **all 10** entries
DO ID	Disease Name	Source
DOID:0060591	WHIM syndrome 1	Alliance of Genome Resources
DOID:0060901	lymphoplasmacytic lymphoma	Alliance of Genome Resources
DOID:10283	prostate cancer	Alliance of Genome Resources
DOID:10534	stomach cancer	Alliance of Genome Resources
DOID:11476	osteoporosis	Alliance of Genome Resources
DOID:3347	osteosarcoma	Alliance of Genome Resources
DOID:4074	pancreatic adenocarcinoma	Alliance of Genome Resources
DOID:5603	T-cell acute lymphoblastic leukemia	Alliance of Genome Resources
DOID:615	leukopenia	Alliance of Genome Resources
DOID:9119	acute myeloid leukemia	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of **132** in total

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Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	643	WB:WBGene00011578
Caenorhabditis elegans	1230	WB:WBGene00011578
Caenorhabditis elegans	1232	WB:WBGene00011578
Caenorhabditis elegans	1233	WB:WBGene00011578
Caenorhabditis elegans	1234	WB:WBGene00011578
Caenorhabditis elegans	1235	WB:WBGene00011578
Caenorhabditis elegans	1236	WB:WBGene00011578
Caenorhabditis elegans	1238	WB:WBGene00011578
Caenorhabditis elegans	2833	WB:WBGene00011578
Caenorhabditis elegans	3577	WB:WBGene00011578

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements