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ALG8 alpha-1,3-glucosyltransferase

Summary

Gene Symbol

ALG8

Aliases

MGC2840
dolichyl-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichol alpha- 1->3-glucosyltransferase

Organism

Homo sapiens (human)

External Links

NCBI Gene

79053

GGDB ID

gg147

HGNC

23161

mRNA

NM_024079

map

11q14.1

Protein

NP_076984

OMIM

608103

KEGG Gene ID

hsa:79053

PubChem

79053

Alliance of Genome Resources

HGNC:23161

JoGo

ALG8

TogoVar

ALG8

Annotation

Keyword

Alternative splicing
Congenital disorder of glycosylation
Disease variant
Endoplasmic reticulum
Glycosyltransferase
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

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UniProt	Protein Name
Q9BVK2	Asparagine-linked glycosylation protein 8 homolog Dol-P-Glc:Glc(1)Man(9)GlcNAc(2)-PP-dolichyl alpha-1,3-glucosyltransferase Dolichyl-P-Glc:Glc1Man9GlcNAc2-PP-dolichyl glucosyltransferase
H0YCV0
A0A024R5K5
H0YEE0
A0A804G6E3
A0A7P0Z449
E9PR58
A0A7P0TAA8
H0YDD3
H0YD42

Annotation information from UniProt.

Gene Ontology (GO)

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GO Term	Evidence Code	PMID
protein N-linked glycosylation	ISS
protein N-linked glycosylation	IMP
protein N-linked glycosylation	IEA
dolichol-linked oligosaccharide biosynthetic process	TAS
dolichol-linked oligosaccharide biosynthetic process	IMP

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

biosynthetic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

primary metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

carbohydrate derivative biosynthetic process [inference]

dolichol-linked oligosaccharide biosynthetic process

glycoprotein biosynthetic process [inference]

protein N-linked glycosylation

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IGI
endoplasmic reticulum membrane	IBA
endoplasmic reticulum membrane	IEA
lumenal side of endoplasmic reticulum membrane	IC

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

side of membrane [inference]

lumenal side of membrane [inference]

lumenal side of endoplasmic reticulum membrane

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GO Term	Evidence Code	PMID
dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity	TAS
protein binding	IPI
hexosyltransferase activity	IEA
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IMP
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity

glucosyltransferase activity [inference]

dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity

dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

alpha-1,3-glucosyltransferase

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
dolichyl pyrophosphate Glc1Man9GlcNAc2 alpha-1,3-glucosyltransferase activity
hexosyltransferase activity
oligosaccharide-lipid intermediate biosynthetic process
protein N-linked glycosylation
transferase activity

Displaying 1 entry
InterPro
Glycosyl transferase, ALG6/ALG8

Human Protein Atlas

ENSG00000159063

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

GlycoGene Database (GGDB)

GGDB ID

gg147

Gene Symbol

ALG8

Reactions

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Glc	G24620AI		G98256YA

Displaying 1 entry
Donor	Acceptor	Reducing terminal(Acceptor)	Product	Reducing terminal(Product)	Reference
Dol-P-Glc	G24620AI		G98256YA

Orthologous Gene

Displaying **all 6** entries
Species	Protein	mRNA
Caenorhabditis elegans	NP_496135	NM_063734
Mus musculus	NP_950200	NM_199035
Saccharomyces cerevisiae	CAA99260	Z74975
Drosophila melanogaster	NP_572355	NM_132127
Rattus norvegicus	XP_214992	XM_214992
Arabidopsis thaliana	NP_181994	NM_130030

KEGG BRITE Database

Orthology

K03849

Name

alpha-1,3-glucosyltransferase [EC:2.4.1.265]

References

Reactions

Displaying 1 entry
KEGG Reaction	Enzyme	Acceptor	Product
R06263	2.4.1.265	G24620AI G71142DF	G98256YA

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060976	polycystic liver disease 3	Alliance of Genome Resources
DOID:0080560	congenital disorder of glycosylation Ih	Glyco-Disease Genes Database Alliance of Genome Resources

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000006	Autosomal dominant inheritance
HP:0000007	Autosomal recessive inheritance
HP:0000028	Cryptorchidism
HP:0000107	Renal cyst
HP:0000158	Macroglossia
HP:0000239	Large fontanelles
HP:0000316	Hypertelorism
HP:0000343	Long philtrum
HP:0000369	Low-set ears
HP:0000470	Short neck

Displaying **all 3** entries
Disease ID	Disease Name
ORPHA:79325	ALG8-congenital disorder of glycosylation
OMIM:617874	polycystic liver disease 3 with or without kidney cysts
OMIM:608104	ALG8-congenital disorder of glycosylation

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements