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MIRAGE
FTO alpha-ketoglutarate dependent dioxygenase

Summary
Gene Symbol
  • FTO
Organism
Homo sapiens (human)
NCBI Gene
79068
KEGG Gene ID
[""]
PubChem
79068
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Acetylation
  • Alternative splicing
  • Cytoplasm
  • Dioxygenase
  • Disease variant
  • Iron
  • Metal-binding
  • Nucleus
  • Obesity
  • Phosphoprotein
  • Proteomics identification
  • Reference proteome
  • Transferase
Proteins
Displaying all 4 entries
UniProt Protein Name
Q9C0B1
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
A0A1B0GTC5
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
B3KU60
  • Fat mass and obesity-associated protein
  • U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • U6 small nuclear RNA N(6)-methyladenosine-demethylase FTO
  • mRNA (2'-O-methyladenosine-N(6)-)-demethylase FTO
  • mRNA N(6)-methyladenosine demethylase FTO
  • tRNA N1-methyl adenine demethylase FTO
Q99770
Annotation information from UniProt.
Gene Ontology (GO)
Displaying entries 1 - 5 of 17 in total
GO Term Evidence Code PMID
temperature homeostasis
DNA alkylation repair
DNA alkylation repair
DNA alkylation repair
regulation of lipid storage
GO Hierarchy
Displaying entries 1 - 5 of 15 in total
GO Term Evidence Code PMID
protein binding
ferrous iron binding
2-oxoglutarate-dependent dioxygenase activity
transferase activity
oxidative RNA demethylase activity
GO Hierarchy
Gene Ontology information from NCBI Gene and UniProt.
OrthoDB (Group)
Group level
Eukaryota
Group Name
alpha-ketoglutarate-dependent dioxygenase FTO
Functional Category
  • E: Amino acid transport and metabolism
  • O: Posttranslational modification, protein turnover, chaperones
  • T: Signal transduction mechanisms
Displaying entries 1 - 10 of 11 in total
Gene Ontology
DNA dealkylation involved in DNA repair
RNA repair
dioxygenase activity
ferrous iron binding
mRNA N6-methyladenosine dioxygenase activity
metal ion binding
oxidative RNA demethylase activity
oxidative single-stranded DNA demethylation
oxidative single-stranded RNA demethylation
oxidoreductase activity
Displaying all 5 entries
InterPro
Alpha-ketoglutarate-dependent dioxygenase AlkB-like superfamily
Alpha-ketoglutarate-dependent dioxygenase FTO, C-terminal
Alpha-ketoglutarate-dependent dioxygenase FTO, catalytic domain
Alpha-ketoglutarate-dependent dioxygenase FTO
FTO, C-terminal domain superfamily
Disease
Disease Ontology
Displaying entries 1 - 10 of 13 in total
DO ID Disease Name Source
DOID:0080334 aortic valve disease 2
DOID:10763 hypertension
DOID:10825 essential hypertension
DOID:1287 cardiovascular system disease
DOID:13963 nuclear senile cataract
DOID:3393 coronary artery disease
DOID:4450 renal cell carcinoma
DOID:4467 clear cell renal cell carcinoma
DOID:5844 myocardial infarction
DOID:9352 type 2 diabetes mellitus
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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026