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acid sensing ion channel subunit 1

Summary

Gene Symbol

Asic1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

79123

KEGG Gene ID

PubChem

79123

Alliance of Genome Resources

RGD:71062

Annotation

Keyword

Alternative splicing
Calcium transport
Cell membrane
Cell projection
Disulfide bond
Glycoprotein
Phosphoprotein
Postsynaptic cell membrane
Reference proteome
Sodium channel
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P55926	Acid-sensing ionic channel Amiloride-sensitive cation channel 2, neuronal Brain sodium channel 2
A6KCG6	Amiloride-sensitive cation channel 2, neuronal Brain sodium channel 2
A6KCG7

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
behavioral fear response	ISO
response to amphetamine	ISO
monoatomic cation transport	ISO
sodium ion transport	IEA
calcium ion transport

GO Hierarchy

biological process

cellular process [inference]

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of chemical stimulus [inference]

sensory perception of taste [inference]

sensory perception of sour taste

cognition [inference]

learning or memory [inference]

learning [inference]

associative learning

memory

behavior [inference]

behavioral defense response [inference]

behavioral fear response

learning or memory [inference]

learning [inference]

associative learning

memory

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

behavioral defense response [inference]

behavioral fear response

multicellular organismal response to stress [inference]

fear response [inference]

behavioral fear response

response to abiotic stimulus [inference]

response to pH [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

response to chemical [inference]

response to nitrogen compound [inference]

response to amine [inference]

response to amphetamine

cellular response to stimulus [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport

metal ion transport [inference]

sodium ion transport

sodium ion transmembrane transport

calcium ion transport

calcium ion transmembrane transport

monoatomic cation transmembrane transport [inference]

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

neurotransmitter transport [inference]

neurotransmitter secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

transmembrane transport

monoatomic ion transmembrane transport

monoatomic cation transmembrane transport [inference]

export from cell [inference]

secretion by cell [inference]

signal release [inference]

signal release from synapse [inference]

neurotransmitter secretion

establishment of localization in cell

neurotransmitter secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of localization [inference]

regulation of transport [inference]

regulation of secretion [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of neurotransmitter transport [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of transport [inference]

negative regulation of secretion [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

negative regulation of neurotransmitter transport [inference]

negative regulation of neurotransmitter secretion

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

negative regulation of cellular process [inference]

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of cellular component organization [inference]

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of secretion by cell [inference]

regulation of neurotransmitter secretion [inference]

negative regulation of neurotransmitter secretion

negative regulation of secretion by cell [inference]

negative regulation of neurotransmitter secretion

regulation of biological quality [inference]

regulation of membrane potential

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
Golgi apparatus
plasma membrane	ISS
plasma membrane	ISO
plasma membrane	EXP
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

cell surface

membrane

plasma membrane

plasma membrane region [inference]

synaptic membrane [inference]

postsynaptic membrane

postsynaptic specialization membrane [inference]

postsynaptic density membrane

cell junction [inference]

synapse

glutamatergic synapse

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

presynapse

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
monoatomic ion channel activity	IDA
ion channel activity	IDA
monoatomic cation channel activity	ISO
sodium channel activity	IEA
ligand-gated sodium channel activity	IBA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated monoatomic ion channel activity

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

metal ion transmembrane transporter activity [inference]

sodium ion transmembrane transporter activity [inference]

sodium channel activity

ligand-gated sodium channel activity

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity

monoatomic cation channel activity

sodium channel activity

ligand-gated sodium channel activity

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated monoatomic ion channel activity

gated channel activity [inference]

ligand-gated channel activity [inference]

ligand-gated monoatomic ion channel activity [inference]

ligand-gated monoatomic cation channel activity [inference]

ligand-gated sodium channel activity

pH-gated monoatomic ion channel activity

monoatomic ion-gated channel activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Acid-sensing ion channel 1

Functional Category

E: Amino acid transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ligand-gated sodium channel activity
monoatomic ion transport
sodium channel activity
sodium ion transmembrane transport

Displaying 1 entry
InterPro
Epithelial sodium channel

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
cell surface	PMID:19074149

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11419	MGI:1194915
Drosophila melanogaster	36864	FB:FBgn0024319
Homo sapiens	41	HGNC:100
Danio rerio	407672	ZFIN:ZDB-GENE-040513-1
Danio rerio	407670	ZFIN:ZDB-GENE-040513-3
Danio rerio	791696	ZFIN:ZDB-GENE-040513-2