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frizzled class receptor 3

Summary

Gene Symbol

FZD3

Organism

Homo sapiens (human)

External Links

NCBI Gene

7976

KEGG Gene ID

PubChem

7976

Alliance of Genome Resources

HGNC:4041

Annotation

Keyword

3D-structure
Alternative splicing
Cell membrane
Developmental protein
Direct protein sequencing
Disulfide bond
G-protein coupled receptor
Glycoprotein
Neurogenesis
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NPG1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 31 in total

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GO Term	Evidence Code	PMID
establishment of planar polarity
neural tube closure
hair follicle development	IEA
positive regulation of neuroblast proliferation	ISS
positive regulation of neuroblast proliferation	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

canonical Wnt signaling pathway

cell population proliferation [inference]

neural precursor cell proliferation [inference]

cell proliferation in midbrain

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

cell motility [inference]

cell migration [inference]

neuron migration [inference]

motor neuron migration

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

plasma membrane bounded cell projection organization [inference]

neuron projection development [inference]

neuron projection guidance [inference]

axon guidance [inference]

multicellular organismal process [inference]

molting cycle process [inference]

hair cycle process [inference]

hair follicle development

developmental process [inference]

anatomical structure morphogenesis [inference]

establishment of tissue polarity [inference]

establishment of planar polarity

post-anal tail morphogenesis

embryonic morphogenesis [inference]

inner ear morphogenesis

midbrain morphogenesis

anatomical structure formation involved in morphogenesis [inference]

tube formation [inference]

tube closure [inference]

neural tube closure

anatomical structure development [inference]

hair follicle development

tissue development [inference]

ganglion development [inference]

sympathetic ganglion development

cellular developmental process [inference]

cell differentiation [inference]

neuron differentiation

response to stimulus [inference]

response to abiotic stimulus [inference]

response to electrical stimulus

response to chemical [inference]

response to xenobiotic stimulus

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of developmental process [inference]

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway [inference]

non-canonical Wnt signaling pathway

Wnt signaling pathway, planar cell polarity pathway

canonical Wnt signaling pathway

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of neural precursor cell proliferation [inference]

regulation of neuroblast proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of neural precursor cell proliferation [inference]

positive regulation of neuroblast proliferation

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

negative regulation of cellular process [inference]

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of execution phase of apoptosis

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

regulation of mitotic cell cycle, embryonic [inference]

negative regulation of mitotic cell cycle, embryonic

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

negative regulation of cell cycle [inference]

negative regulation of mitotic cell cycle [inference]

negative regulation of mitotic cell cycle, embryonic

regulation of execution phase of apoptosis [inference]

negative regulation of execution phase of apoptosis

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of neuroblast proliferation

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
cell surface	ISS
cell surface	IEA
membrane	IEA
apical plasma membrane	ISS
apical plasma membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

plasma membrane region [inference]

apical plasma membrane

synaptic membrane [inference]

presynaptic active zone membrane

lateral plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

filopodium tip

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

cell body [inference]

neuronal cell body

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GO Term	Evidence Code	PMID
transmembrane signaling receptor activity	IEA
G protein-coupled receptor activity
protein binding	IPI
Wnt-protein binding	NAS
Wnt-protein binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

Wnt-protein binding

protein domain specific binding [inference]

PDZ domain binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

frizzled class receptor 6

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
Wnt receptor activity
Wnt-protein binding
canonical Wnt signaling pathway
cell surface receptor signaling pathway
non-canonical Wnt signaling pathway

Displaying **all 5** entries
InterPro
Frizzled cysteine-rich domain superfamily
Frizzled domain
Frizzled/Smoothened, 7TM
Frizzled/secreted frizzled-related protein
GPCR, family 2-like, 7TM

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:1928	Williams-Beuren syndrome	Alliance of Genome Resources
DOID:5419	schizophrenia	Alliance of Genome Resources

Ortholog

Displaying **all 3** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14365	MGI:108476
Caenorhabditis elegans	172856	WB:WBGene00003397
Xenopus laevis	399190	Xenbase:XB-GENE-865070

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements