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Guidelines

MIRAGE

myosin heavy chain 14

Summary

Gene Symbol

MYH14

Organism

Homo sapiens (human)

External Links

NCBI Gene

79784

KEGG Gene ID

PubChem

79784

Alliance of Genome Resources

HGNC:23212

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Actin-binding
Alternative splicing
Calmodulin-binding
Cell shape
Coiled coil
Cytoplasm
Direct protein sequencing
Disease variant
Myosin
Neuropathy
Non-syndromic deafness
Phosphoprotein
Proteomics identification
Reference proteome
Thick filament

Proteins

Displaying **all 3** entries
UniProt	Protein Name
B3KWH4
A1L2Z2
Q7Z406	Myosin heavy chain 14 Myosin heavy chain, non-muscle IIc Non-muscle myosin heavy chain IIc

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	IBA
skeletal muscle contraction	IMP
mitochondrion organization	IMP
skeletal muscle tissue development	IMP
sensory perception of sound	IMP

GO Hierarchy

biological process

cellular process [inference]

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

actin filament-based process

actin cytoskeleton organization [inference]

actomyosin structure organization

actin filament-based movement

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

mitochondrion organization

cytoskeleton organization [inference]

actin cytoskeleton organization [inference]

actomyosin structure organization

multicellular organismal process [inference]

system process [inference]

muscle system process [inference]

muscle contraction [inference]

striated muscle contraction [inference]

skeletal muscle contraction

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

vocalization behavior

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

muscle tissue development [inference]

striated muscle tissue development [inference]

skeletal muscle tissue development

biological regulation [inference]

regulation of biological process [inference]

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

regulation of cell shape

regulation of biological quality [inference]

regulation of cell shape

regulation of membrane potential [inference]

action potential [inference]

neuronal action potential

Displaying entries **16 - 18** of 18 in total

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GO Term	Evidence Code	PMID
extracellular exosome	HDA
myosin II filament	IDA
supramolecular fiber	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin II complex

cellular anatomical structure [inference]

site of polarized growth [inference]

growth cone

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

membraneless organelle [inference]

intracellular membraneless organelle [inference]

contractile muscle fiber [inference]

myofibril

intracellular organelle [inference]

intracellular membraneless organelle [inference]

contractile muscle fiber [inference]

myofibril

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber

myosin filament

myosin II filament

contractile muscle fiber [inference]

myofibril

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
microfilament motor activity	IDA
microfilament motor activity	IEA
cytoskeletal motor activity	IEA
actin binding
calmodulin binding

GO Hierarchy

molecular function

cytoskeletal motor activity

microfilament motor activity

catalytic activity [inference]

isomerase activity [inference]

macromolecular conformation isomerase activity [inference]

polypeptide conformation or assembly isomerase activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin filament binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
ATP binding
actin binding
actin filament binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 7** entries
InterPro
IQ motif, EF-hand binding site
Kinesin motor domain superfamily
Myosin S1 fragment, N-terminal
Myosin head, motor domain
Myosin tail
Myosin, N-terminal, SH3-like
P-loop containing nucleoside triphosphate hydrolase

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110573	autosomal dominant nonsyndromic deafness 4A	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026