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MIRAGE

post-GPI attachment to proteins inositol deacylase 1

Summary

Gene Symbol

PGAP1

Aliases

Bst1
FLJ12377
GPI inositol-deacylase
SPG67

Organism

Homo sapiens (human)

External Links

NCBI Gene

80055

HGNC

25712

KEGG Gene ID

hsa:80055

PubChem

80055

Alliance of Genome Resources

HGNC:25712

JoGo

PGAP1

TogoVar

PGAP1

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Glycoprotein
Hydrolase
Intellectual disability
Protein transport
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q75T13	Post-GPI attachment to proteins factor 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	IBA
sensory perception of sound
embryonic pattern specification
anterior/posterior axis specification
protein transport

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein maturation [inference]

attachment of GPI anchor to protein

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

protein metabolic process [inference]

protein maturation [inference]

attachment of GPI anchor to protein

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

pattern specification process [inference]

regionalization [inference]

forebrain regionalization

axis specification [inference]

anterior/posterior axis specification

embryonic pattern specification

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

protein transport

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

positive regulation of transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular process [inference]

positive regulation of cellular process [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

positive regulation of intracellular transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

regulation of vesicle-mediated transport [inference]

regulation of ER to Golgi vesicle-mediated transport [inference]

positive regulation of ER to Golgi vesicle-mediated transport

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA
endoplasmic reticulum membrane	ISS
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IEA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 5** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on ester bonds	TAS
hydrolase activity, acting on ester bonds	IEA
phosphatidylinositol deacylase activity
deacylase activity	IDA
deacylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds

carboxylic ester hydrolase activity [inference]

phosphatidylinositol deacylase activity

deacylase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K05294

Name

GPI inositol-deacylase [EC:3.-.-.-]

References

14734546

Disease

The Human Phenotype Ontology

Displaying entries **1 - 10** of 65 in total

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000154	Wide mouth
HP:0000164	Abnormality of the dentition
HP:0000193	Bifid uvula
HP:0000252	Microcephaly
HP:0000294	Low anterior hairline
HP:0000395	Prominent antihelix
HP:0000400	Macrotia
HP:0000470	Short neck
HP:0000490	Deeply set eye

Displaying **all 2** entries
Disease ID	Disease Name
ORPHA:401820	autosomal recessive spastic paraplegia type 67
OMIM:615802	intellectual disability, autosomal recessive 42

PubChem Disease

MedGen Diseases

Intellectual disability, autosomal recessive 42

OMIM Phenotypes

NEURODEVELOPMENTAL DISORDER WITH DYSMORPHIC FEATURES, SPASTICITY, AND BRAIN ABNORMALITIES; NEDDSBA

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP006714
Gene Name: post-GPI attachment to proteins 1

Ortholog

Displaying **all 6** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	241062	MGI:2443342
Rattus norvegicus	316400	RGD:1303213
Caenorhabditis elegans	179556	WB:WBGene00011835
Drosophila melanogaster	31487	FB:FBgn0029789
Saccharomyces cerevisiae S288C	850519	SGD:S000001869
Xenopus laevis	447534	Xenbase:XB-GENE-5818693

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026