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phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2

Summary

Gene Symbol

PREX2

Organism

Homo sapiens (human)

External Links

NCBI Gene

80243

PubChem

80243

Alliance of Genome Resources

HGNC:22950

Annotation

Keyword

3D-structure
Alternative splicing
Guanine-nucleotide releasing factor
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q70Z35	DEP domain-containing protein 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA
dendrite morphogenesis	IEA
regulation of small GTPase mediated signal transduction	TAS

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

multicellular organismal process [inference]

behavior [inference]

locomotory behavior [inference]

adult locomotory behavior

adult behavior [inference]

adult locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

cellular anatomical entity morphogenesis [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

dendrite morphogenesis

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

negative regulation of TOR signaling

regulation of small GTPase mediated signal transduction

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of intracellular signal transduction [inference]

negative regulation of TOR signaling

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
guanyl-nucleotide exchange factor activity	TAS
guanyl-nucleotide exchange factor activity	IDA	15304343
guanyl-nucleotide exchange factor activity	IBA
GTPase activator activity	IDA	15304343
GTPase activator activity	IBA

GO Hierarchy

molecular function

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

enzyme activator activity [inference]

GTPase activator activity

kinase regulator activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

protein kinase regulator activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

nucleoside-triphosphatase regulator activity [inference]

GTPase regulator activity [inference]

molecular function activator activity [inference]

enzyme activator activity [inference]

GTPase activator activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

kinase inhibitor activity [inference]

protein kinase inhibitor activity [inference]

protein serine/threonine kinase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Leucine rich repeat

Functional Category

K: Transcription
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:4927	Klatskin's tumor	Alliance of Genome Resources
DOID:4947	cholangiocarcinoma	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 81 in total

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Species	Gene ID	Orthologous MAtrix
Rhinopithecus roxellana	104668816	RHIRO10414
Esox lucius	105005811	ESOLU61892
Macaca nemestrina	105482163	MACNE20998
Cercocebus atys	105585240	CERAT18873
Aotus nancymaae	105724838	AOTNA06618
Equus asinus asinus	106829399	EQUAS26098
Cyprinodon variegatus	107104438	CYPVA30785
Sinocyclocheilus grahami	107584988	SINGR34777
Kryptolebias marmoratus	108230517	KRYMA03635
Pygocentrus nattereri	108438254	PYGNA02474