GlyCosmos Portal

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Cytoskeleton
Direct protein sequencing
Hydrolase
Methylation
Nucleus
Oxidation
Reference proteome
Ubl conjugation

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A6K1N6
P60711	Beta-actin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 26 in total

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GO Term	Evidence Code	PMID
morphogenesis of a polarized epithelium	ISO
cytoskeleton organization	IMP
microtubule-based process	ISO
establishment or maintenance of cell polarity	ISO
axonogenesis	IDA

GO Hierarchy

biological process

cellular process [inference]

actin filament-based process [inference]

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cell motility

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cytochalasin B

cellular response to oxygen-containing compound [inference]

cellular response to cytochalasin B

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

actin cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

postsynaptic cytoskeleton organization [inference]

postsynaptic actin cytoskeleton organization

cellular component assembly [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

cell projection organization [inference]

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

cell junction organization [inference]

cell junction assembly [inference]

cell-cell junction assembly [inference]

adherens junction assembly

cell-cell junction organization [inference]

cell-cell junction assembly [inference]

adherens junction assembly

adherens junction organization [inference]

adherens junction assembly

developmental process [inference]

anatomical structure morphogenesis [inference]

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

morphogenesis of a polarized epithelium

cell projection morphogenesis [inference]

plasma membrane bounded cell projection morphogenesis [inference]

neuron projection morphogenesis [inference]

axonogenesis

anatomical structure development [inference]

retina development in camera-type eye

rhythmic process [inference]

circadian rhythm

response to stimulus [inference]

response to stress [inference]

response to immobilization stress

response to external stimulus [inference]

response to mechanical stimulus

response to abiotic stimulus [inference]

response to mechanical stimulus

response to electrical stimulus [inference]

cellular response to electrical stimulus

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cytochalasin B

cellular response to oxygen-containing compound [inference]

cellular response to cytochalasin B

response to nitrogen compound [inference]

response to cytochalasin B [inference]

cellular response to cytochalasin B

cellular response to nitrogen compound [inference]

cellular response to cytochalasin B

response to oxygen-containing compound [inference]

response to cytochalasin B [inference]

cellular response to cytochalasin B

cellular response to oxygen-containing compound [inference]

cellular response to cytochalasin B

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to cytochalasin B

cellular response to oxygen-containing compound [inference]

cellular response to cytochalasin B

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to electrical stimulus

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

apical protein localization

protein localization to cell junction [inference]

protein localization to cell-cell junction [inference]

protein localization to adherens junction

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of protein localization [inference]

regulation of protein localization to cell periphery [inference]

regulation of protein localization to plasma membrane

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

regulation of transport [inference]

regulation of norepinephrine uptake

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of transepithelial transport

regulation of synaptic vesicle recycling [inference]

regulation of synaptic vesicle endocytosis

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA recombination [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of DNA metabolic process [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of DNA recombination [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of cell cycle

regulation of cellular localization [inference]

regulation of protein localization to membrane [inference]

regulation of protein localization to plasma membrane

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

regulation of synaptic vesicle endocytosis

regulation of cellular response to stress [inference]

regulation of DNA repair [inference]

positive regulation of DNA repair [inference]

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

regulation of double-strand break repair [inference]

regulation of double-strand break repair via homologous recombination [inference]

positive regulation of double-strand break repair via homologous recombination

positive regulation of double-strand break repair [inference]

positive regulation of double-strand break repair via homologous recombination

Displaying entries **1 - 5** of 42 in total

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GO Term	Evidence Code	PMID
nucleosome	ISO
stress fiber	IDA
podosome	IDA
nucleus	ISS
nucleus	ISO

GO Hierarchy

cellular component

protein-containing complex

protein-DNA complex [inference]

nucleosome

intracellular protein-containing complex [inference]

protein acetyltransferase complex [inference]

histone acetyltransferase complex [inference]

H4 histone acetyltransferase complex [inference]

H4/H2A histone acetyltransferase complex [inference]

NuA4 histone acetyltransferase complex

catalytic complex [inference]

transferase complex [inference]

acetyltransferase complex [inference]

protein acetyltransferase complex [inference]

histone acetyltransferase complex [inference]

H4 histone acetyltransferase complex [inference]

H4/H2A histone acetyltransferase complex [inference]

NuA4 histone acetyltransferase complex

ribonucleoprotein complex

cellular anatomical structure [inference]

membrane

plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

synapse

anchoring junction [inference]

cell-cell junction

cell-substrate junction [inference]

focal adhesion

actin filament bundle [inference]

contractile actin filament bundle [inference]

stress fiber

actomyosin [inference]

stress fiber

cell projection [inference]

plasma membrane bounded cell projection [inference]

lamellipodium

neuron projection [inference]

axon

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

podosome

cytoskeleton

actin cytoskeleton

postsynaptic actin cytoskeleton

cortical cytoskeleton

postsynaptic cytoskeleton [inference]

postsynaptic actin cytoskeleton

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

neuron projection terminus [inference]

axon terminus [inference]

calyx of Held

dense body

presynapse [inference]

axon terminus [inference]

calyx of Held

cluster of actin-based cell projections [inference]

brush border

supramolecular complex [inference]

ribonucleoprotein granule [inference]

cytoplasmic ribonucleoprotein granule

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

actin filament

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding
ATP hydrolysis activity	ISS
ATP hydrolysis activity	ISO
kinesin binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

structural molecule activity [inference]

structural constituent of cytoskeleton [inference]

structural constituent of postsynaptic actin cytoskeleton

structural constituent of synapse [inference]

structural constituent of postsynapse [inference]

structural constituent of postsynaptic actin cytoskeleton

binding [inference]

protein binding

cytoskeletal protein binding [inference]

kinesin binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

Tat protein binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding

nitric-oxide synthase binding

identical protein binding

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

molecular function regulator activity [inference]

enzyme regulator activity [inference]

nitric-oxide synthase regulator activity

transporter regulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Actin

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
InterPro
ATPase, nucleotide binding domain
Actin family
Actin/actin-like conserved site

Alliance of Genome Resources

Expression

Displaying **all 4** entries
Location	References
podosome	PMID:17111031
protein-containing complex	PMID:15823548
stress fiber	PMID:17111031
axon	PMID:12504890

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0080208	metabolic dysfunction-associated steatotic liver disease	Alliance of Genome Resources

Ortholog

Displaying **all 2** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	11461	MGI:87904
Homo sapiens	60	HGNC:132

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements