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frizzled class receptor 4

Summary

Gene Symbol

FZD4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8322

KEGG Gene ID

PubChem

8322

Alliance of Genome Resources

HGNC:4042

Annotation

Keyword

3D-structure
Cell membrane
Developmental protein
Disease variant
Disulfide bond
G-protein coupled receptor
Glycoprotein
Proteomics identification
Reference proteome
Signal
Transmembrane helix
Ubl conjugation
Wnt signaling pathway

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9ULV1	FzE4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
angiogenesis
vasculogenesis
response to hypoxia
cell surface receptor signaling pathway	IEA
Wnt signaling pathway, calcium modulating pathway	IDA

GO Hierarchy

biological process

cellular process [inference]

cell communication [inference]

extracellular matrix-cell signaling

cell adhesion [inference]

cell-substrate adhesion [inference]

substrate adhesion-dependent cell spreading

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

non-canonical Wnt signaling pathway

Wnt signaling pathway, calcium modulating pathway

canonical Wnt signaling pathway

cell population proliferation

cellular process involved in reproduction in multicellular organism [inference]

progesterone secretion

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

endothelial cell differentiation

cell development [inference]

establishment of blood-brain barrier

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

progesterone secretion

lipid export from cell [inference]

steroid hormone secretion [inference]

progesterone secretion

reproductive process [inference]

ovulation cycle process [inference]

progesterone secretion

multicellular organismal reproductive process [inference]

cellular process involved in reproduction in multicellular organism [inference]

progesterone secretion

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

blood vessel morphogenesis [inference]

retinal blood vessel morphogenesis

retina vasculature morphogenesis in camera-type eye

retinal blood vessel morphogenesis

cerebellum vasculature morphogenesis

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

anatomical structure development [inference]

cell development [inference]

establishment of blood-brain barrier

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation [inference]

endothelial cell differentiation

cell development [inference]

establishment of blood-brain barrier

locomotion [inference]

locomotion involved in locomotory behavior

rhythmic process [inference]

ovulation cycle process [inference]

progesterone secretion

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

response to chemical [inference]

response to lipid [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

response to peptide [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

response to oxygen-containing compound [inference]

response to retinoic acid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to lipid [inference]

cellular response to retinoic acid

cellular response to oxygen-containing compound [inference]

cellular response to retinoic acid

localization [inference]

establishment of localization [inference]

transport [inference]

lipid transport [inference]

lipid export from cell [inference]

steroid hormone secretion [inference]

progesterone secretion

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

progesterone secretion

secretion [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

progesterone secretion

export from cell [inference]

secretion by cell [inference]

signal release [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

progesterone secretion

lipid export from cell [inference]

steroid hormone secretion [inference]

progesterone secretion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

signaling [inference]

extracellular matrix-cell signaling

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neuron projection arborization

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of cell morphogenesis [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of neuron projection arborization [inference]

positive regulation of neuron projection arborization

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of developmental process [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neuron projection arborization

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

Wnt signaling pathway

non-canonical Wnt signaling pathway

Wnt signaling pathway, calcium modulating pathway

canonical Wnt signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell-substrate adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cell differentiation [inference]

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of cell development [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of transcription, DNA-templated

positive regulation of transcription by RNA polymerase II

positive regulation of cell differentiation [inference]

positive regulation of cell development [inference]

positive regulation of cell morphogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cell adhesion [inference]

negative regulation of cell-substrate adhesion

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

regulation of dendrite development [inference]

regulation of dendrite morphogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of neuron projection arborization [inference]

positive regulation of neuron projection arborization

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

positive regulation of multicellular organismal process [inference]

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of multicellular organismal development [inference]

regulation of nervous system development [inference]

regulation of neurogenesis [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

positive regulation of nervous system development [inference]

positive regulation of neurogenesis [inference]

positive regulation of dendrite morphogenesis

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

endocrine hormone secretion [inference]

steroid hormone secretion [inference]

progesterone secretion

Displaying entries **1 - 5** of 16 in total

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GO Term	Evidence Code	PMID
nucleoplasm
plasma membrane	TAS
plasma membrane	IC
plasma membrane	IDA
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

bounding membrane of organelle [inference]

coated vesicle membrane [inference]

clathrin-coated vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

endocytic vesicle membrane [inference]

clathrin-coated endocytic vesicle membrane

cell junction [inference]

synapse

glutamatergic synapse

anchoring junction [inference]

cell-cell junction

cell projection [inference]

plasma membrane bounded cell projection [inference]

cilium

neuron projection [inference]

dendrite

organelle [inference]

membrane-bounded organelle [inference]

cilium

Displaying entries **1 - 5** of 21 in total

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GO Term	Evidence Code	PMID
amyloid-beta binding	IPI
transmembrane signaling receptor activity	IEA
cytokine receptor activity	IDA
G protein-coupled receptor activity
protein binding	IPI

GO Hierarchy

molecular function

binding [inference]

protein binding

Wnt-protein binding

enzyme binding [inference]

ubiquitin-like protein ligase binding [inference]

ubiquitin protein ligase binding

protein domain specific binding [inference]

PDZ domain binding

cytokine binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

peptide binding [inference]

amyloid-beta binding

protein-containing complex binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

immune receptor activity [inference]

cytokine receptor activity

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0111412	exudative vitreoretinopathy 1	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Mus musculus	14366	MGI:108520
Rattus norvegicus	64558	RGD:71017
Drosophila melanogaster	31659	FB:FBgn0027342
Xenopus laevis	399192	Xenbase:XB-GENE-865153

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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External Links

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Acknowledgements