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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

cystinosis, nephropathic

Summary

Gene Symbol

Ctns

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

83429

KEGG Gene ID

PubChem

83429

Alliance of Genome Resources

MGI:1932872

Annotation

Keyword

Glycoprotein
Lysosome
Melanin biosynthesis
Protein transport
Reference proteome
Repeat
Signal
Symport
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q542U5
P57757

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 41 in total

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GO Term	Evidence Code	PMID
lens development in camera-type eye	IMP
glutathione metabolic process	ISO
glutathione metabolic process	IEA
brain development	ISO
brain development	IEA

GO Hierarchy

biological process

cellular process [inference]

metabolic process [inference]

modified amino acid metabolic process [inference]

glutathione metabolic process

sulfur compound metabolic process [inference]

glutathione metabolic process

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

organophosphate metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

biosynthetic process [inference]

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

phenol-containing compound metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

phenol-containing compound biosynthetic process [inference]

melanin biosynthetic process

secondary metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

secondary metabolite biosynthetic process [inference]

melanin biosynthetic process

pigment metabolic process [inference]

melanin metabolic process [inference]

melanin biosynthetic process

pigment biosynthetic process [inference]

melanin biosynthetic process

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

small molecule metabolic process [inference]

nucleobase-containing small molecule metabolic process [inference]

nucleoside phosphate metabolic process [inference]

nucleotide metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

nucleoside triphosphate metabolic process [inference]

purine nucleoside triphosphate metabolic process [inference]

purine ribonucleoside triphosphate metabolic process [inference]

ATP metabolic process

purine-containing compound metabolic process [inference]

purine nucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

carbohydrate derivative metabolic process [inference]

ribose phosphate metabolic process [inference]

ribonucleotide metabolic process [inference]

purine ribonucleotide metabolic process [inference]

ATP metabolic process

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

D-glucose transmembrane transport [inference]

renal D-glucose absorption

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

cellular component organization or biogenesis [inference]

cellular component organization [inference]

cellular component assembly [inference]

brush border assembly

multicellular organismal process [inference]

system process [inference]

renal system process [inference]

renal water transport [inference]

renal water absorption

renal absorption [inference]

renal protein absorption [inference]

renal albumin absorption

renal phosphate ion absorption

nervous system process [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory [inference]

long-term memory

behavior [inference]

learning or memory [inference]

learning [inference]

associative learning [inference]

visual learning

memory [inference]

long-term memory

grooming behavior

locomotory behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

walking behavior [inference]

adult walking behavior

visual behavior [inference]

visual learning

adult behavior [inference]

adult locomotory behavior [inference]

adult walking behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

proximal tubule morphogenesis

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

renal tubule morphogenesis [inference]

nephron tubule morphogenesis [inference]

proximal tubule morphogenesis

nephron epithelium morphogenesis [inference]

nephron tubule morphogenesis [inference]

proximal tubule morphogenesis

anatomical structure development [inference]

lens development in camera-type eye

animal organ development

brain development

gland development [inference]

thyroid gland development

system development

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus [inference]

visual behavior [inference]

visual learning

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein transport

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

amino acid transport [inference]

neutral amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

carbohydrate transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

D-glucose transmembrane transport [inference]

renal D-glucose absorption

protein transport

organic anion transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

organic acid transport [inference]

carboxylic acid transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

fluid transport [inference]

water transport [inference]

renal water transport [inference]

renal water absorption

transmembrane transport [inference]

carbohydrate transmembrane transport [inference]

monosaccharide transmembrane transport [inference]

hexose transmembrane transport [inference]

D-glucose transmembrane transport [inference]

renal D-glucose absorption

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

proton transmembrane transport

nitrogen compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

L-amino acid transport [inference]

L-cystine transport

modified amino acid transport [inference]

L-cystine transport

sulfur compound transport [inference]

sulfur amino acid transport [inference]

L-cystine transport

establishment of protein localization [inference]

protein transport

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of TORC1 signaling

positive regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of TORC1 signaling

positive regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of intracellular signal transduction [inference]

regulation of TOR signaling [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of TORC1 signaling

positive regulation of TORC1 signaling

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

positive regulation of metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of secondary metabolic process [inference]

regulation of secondary metabolite biosynthetic process [inference]

regulation of melanin biosynthetic process

regulation of reactive oxygen species metabolic process [inference]

regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

regulation of hydrogen peroxide biosynthetic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

regulation of reactive oxygen species biosynthetic process [inference]

regulation of hydrogen peroxide biosynthetic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of TOR signaling [inference]

positive regulation of TORC1 signaling

negative regulation of cellular process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species metabolic process [inference]

negative regulation of hydrogen peroxide metabolic process [inference]

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of reactive oxygen species biosynthetic process

negative regulation of hydrogen peroxide biosynthetic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process

regulation of biological quality [inference]

regulation of hormone levels [inference]

regulation of hormone metabolic process [inference]

positive regulation of hormone metabolic process [inference]

positive regulation of thyroid hormone generation

regulation of thyroid hormone generation [inference]

positive regulation of thyroid hormone generation

regulation of membrane potential [inference]

positive regulation of membrane potential [inference]

positive regulation of mitochondrial membrane potential

regulation of mitochondrial membrane potential [inference]

positive regulation of mitochondrial membrane potential

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
lysosome	ISO
lysosome	IDA
lysosome	IEA
lysosomal membrane	ISS
lysosomal membrane	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

pigment granule membrane [inference]

melanosome membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

pigment granule membrane [inference]

melanosome membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

pigment granule [inference]

melanosome

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

pigment granule [inference]

melanosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

late endosome

pigment granule [inference]

melanosome

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
L-cystine transmembrane transporter activity	ISO
L-cystine transmembrane transporter activity	IDA
L-cystine transmembrane transporter activity	IMP
L-cystine transmembrane transporter activity	IBA
L-cystine transmembrane transporter activity	IEA

GO Hierarchy

molecular function

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

solute:proton symporter activity

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

amino acid transmembrane transporter activity [inference]

L-amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

active transmembrane transporter activity [inference]

secondary active transmembrane transporter activity [inference]

symporter activity [inference]

solute:monoatomic cation symporter activity [inference]

solute:proton symporter activity

carboxylic acid transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

L-amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

modified amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

sulfur compound transmembrane transporter activity [inference]

sulfur amino acid transmembrane transporter activity [inference]

L-cystine transmembrane transporter activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

cystinosin

Functional Category

O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
L-cystine transmembrane transporter activity

Displaying **all 2** entries
InterPro
Lysosomal cystine transporter
PQ-loop repeat

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1064	cystinosis	Alliance of Genome Resources

Ortholog

Displaying **all 4** entries
Species	Gene ID	Alliance of Genome Resources
Caenorhabditis elegans	174308	WB:WBGene00008052
Drosophila melanogaster	42723	FB:FBgn0039045
Homo sapiens	1497	HGNC:2518
Saccharomyces cerevisiae S288C	850438	SGD:S000000671

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Acknowledgements

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GlyCosmos Portal v4.5.0

Last updated: April 6, 2026