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H4 clustered histone 4

Summary

Gene Symbol

H4C4

Organism

Homo sapiens (human)

External Links

NCBI Gene

8360

KEGG Gene ID

PubChem

8360

Alliance of Genome Resources

HGNC:4782

Annotation

Keyword

3D-structure
Acetylation
Chromosomal rearrangement
Citrullination
Direct protein sequencing
Disease variant
Hydroxylation
Intellectual disability
Isopeptide bond
Methylation
Nucleosome core
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P62805

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chromatin organization	NAS
nucleosome assembly	IDA
nucleosome assembly	IBA
telomere organization	TAS
negative regulation of megakaryocyte differentiation	IDA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

chromatin organization

chromatin remodeling [inference]

nucleosome organization [inference]

nucleosome assembly

organelle organization [inference]

chromosome organization [inference]

telomere organization

cellular component assembly [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-containing complex organization [inference]

protein-containing complex assembly [inference]

protein-DNA complex assembly [inference]

nucleosome assembly

protein-DNA complex organization [inference]

nucleosome organization [inference]

nucleosome assembly

protein-DNA complex assembly [inference]

nucleosome assembly

localization [inference]

macromolecule localization [inference]

intracellular protein localization [inference]

protein localization to organelle [inference]

protein localization to chromosome [inference]

protein localization to chromatin [inference]

protein localization to CENP-A containing chromatin

protein localization to chromosome, centromeric region [inference]

protein localization to CENP-A containing chromatin

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of developmental process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of developmental process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cellular process [inference]

regulation of cell differentiation [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of cell development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

negative regulation of cellular process [inference]

negative regulation of cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of multicellular organismal process [inference]

regulation of multicellular organismal development [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation [inference]

negative regulation of megakaryocyte differentiation

regulation of megakaryocyte differentiation [inference]

negative regulation of megakaryocyte differentiation

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
DNA binding	TAS
DNA binding	IEA
RNA binding	HDA
protein binding	IPI
structural constituent of chromatin	IDA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of chromatin

binding [inference]

nucleic acid binding [inference]

protein binding

protein dimerization activity [inference]

protein heterodimerization activity

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying 1 entry
Species	Gene ID	Alliance of Genome Resources
Mus musculus	100041230	MGI:2448441

International Collaboration

GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026

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