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MIRAGE

caspase 6

Summary

Gene Symbol

CASP6

Organism

Homo sapiens (human)

External Links

NCBI Gene

839

KEGG Gene ID

[""]

PubChem

839

Alliance of Genome Resources

HGNC:1507

Annotation

Keyword

3D-structure
Alternative splicing
Apoptosis
Autocatalytic cleavage
Cytoplasm
Nucleus
Palmitate
Phosphoprotein
Proteomics identification
Reference proteome
Thiol protease
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P55212	Apoptotic protease Mch-2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
activation of innate immune response	IDA
proteolysis	TAS
proteolysis	IDA
proteolysis	IEA
apoptotic process	TAS

GO Hierarchy

biological process

immune system process [inference]

activation of immune response [inference]

activation of innate immune response

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

protein maturation

protein processing [inference]

protein autoprocessing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

protein maturation

protein processing [inference]

protein autoprocessing

cell death [inference]

programmed cell death [inference]

apoptotic process

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

developmental process [inference]

cellular developmental process [inference]

cell differentiation [inference]

epithelial cell differentiation

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response [inference]

pyroptotic inflammatory response

response to chemical [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to nitrogen compound [inference]

response to alkaloid [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

response to staurosporine [inference]

cellular response to staurosporine

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to nitrogen compound [inference]

cellular response to alkaloid [inference]

cellular response to staurosporine

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of localization [inference]

regulation of transport [inference]

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stimulus [inference]

regulation of response to biotic stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to stimulus [inference]

positive regulation of response to biotic stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of response to external stimulus [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of immune response [inference]

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

positive regulation of immune response [inference]

activation of immune response [inference]

activation of innate immune response

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of innate immune response [inference]

positive regulation of innate immune response [inference]

activation of innate immune response

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

signal transduction by p53 class mediator [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway [inference]

intrinsic apoptotic signaling pathway by p53 class mediator

regulation of programmed cell death

regulation of apoptotic process [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

regulation of neuron apoptotic process [inference]

positive regulation of neuron apoptotic process

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

regulation of programmed necrotic cell death [inference]

regulation of necroptotic process [inference]

positive regulation of necroptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

positive regulation of cellular process [inference]

positive regulation of programmed cell death [inference]

positive regulation of apoptotic process

positive regulation of neuron apoptotic process

positive regulation of programmed necrotic cell death [inference]

positive regulation of necroptotic process

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

regulation of mitochondrion organization [inference]

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

regulation of biological quality [inference]

regulation of membrane permeability [inference]

regulation of mitochondrial membrane permeability [inference]

regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
fibrillar center	IDA
nucleus	IDA
nucleus	IEA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

membraneless organelle [inference]

intracellular membraneless organelle [inference]

nucleolus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular membraneless organelle [inference]

nucleolus

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
endopeptidase activity	IEA
cysteine-type endopeptidase activity	ISS
cysteine-type endopeptidase activity	IDA
cysteine-type endopeptidase activity	IMP
cysteine-type endopeptidase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

cysteine-type endopeptidase activity

cysteine-type peptidase activity

cysteine-type endopeptidase activity

binding [inference]

protein binding

identical protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Caspase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
cysteine-type endopeptidase activity
hydrolase activity
positive regulation of neuron apoptotic process
proteolysis

Displaying **all 7** entries
InterPro
Caspase-like domain superfamily
Peptidase C14, caspase domain
Peptidase C14, caspase non-catalytic subunit p10
Peptidase C14, p20 domain
Peptidase C14A, caspase catalytic domain
Peptidase family C14A, His active site
Peptidase family C14A, cysteine active site

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:4001	ovarian carcinoma	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026