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phosphatidylinositol-5-phosphate 4-kinase type 2 beta

Summary

Gene Symbol

PIP4K2B

Aliases

PIP5KIIB
PIP5KIIbeta

Organism

Homo sapiens (human)

External Links

NCBI Gene

8396

HGNC

8998

KEGG Gene ID

hsa:8396

PubChem

8396

Alliance of Genome Resources

HGNC:8998

JoGo

PIP4K2B

TogoVar

PIP4K2B

Annotation

Keyword

3D-structure
ATP-binding
Acetylation
Alternative splicing
Cell membrane
Cytoplasm
Endoplasmic reticulum
GTP-binding
Kinase
Lipid metabolism
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation

Proteins

Displaying 1 entry
UniProt	Protein Name
P78356	1-phosphatidylinositol 5-phosphate 4-kinase 2-beta Diphosphoinositide kinase 2-beta Phosphatidylinositol 5-phosphate 4-kinase type II beta PtdIns(5)P-4-kinase isoform 2-beta

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
cell surface receptor signaling pathway	TAS
regulation of autophagy	ISS
regulation of autophagy	IMP
regulation of autophagy	IEA
phosphatidylinositol metabolic process	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process [inference]

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process [inference]

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

phosphatidylinositol metabolic process

biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process [inference]

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate metabolic process [inference]

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

organelle fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

membrane organization [inference]

membrane fusion [inference]

organelle membrane fusion [inference]

vesicle fusion [inference]

autophagosome-lysosome fusion

biological regulation [inference]

regulation of biological process [inference]

regulation of signaling [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of insulin receptor signaling pathway [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of autophagy

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of macroautophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of autophagy [inference]

positive regulation of macroautophagy [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component biogenesis [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

negative regulation of cellular process [inference]

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of insulin receptor signaling pathway

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

regulation of cellular component organization [inference]

regulation of organelle organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of vacuole organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

regulation of organelle assembly [inference]

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of autophagosome assembly [inference]

positive regulation of autophagosome assembly

positive regulation of cellular component organization [inference]

positive regulation of organelle organization [inference]

positive regulation of vacuole organization [inference]

positive regulation of autophagosome assembly

positive regulation of organelle assembly [inference]

positive regulation of autophagosome assembly

regulation of cellular response to insulin stimulus [inference]

negative regulation of cellular response to insulin stimulus [inference]

negative regulation of insulin receptor signaling pathway

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
nucleus	EXP
nucleus	IDA
nucleus	IEA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

cellular anatomical structure [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

vacuole [inference]

autophagosome

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
protein binding	IPI
ATP binding	IDA
GTP binding	IDA
1-phosphatidylinositol-4-phosphate 5-kinase activity	IDA
1-phosphatidylinositol-4-phosphate 5-kinase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

lipid kinase activity [inference]

phosphatidylinositol kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity

binding [inference]

protein binding

identical protein binding [inference]

protein homodimerization activity

protein dimerization activity [inference]

protein homodimerization activity

small molecule binding [inference]

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatidylinositol 5-phosphate 4-kinase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 7** entries
Gene Ontology
1-phosphatidylinositol-5-phosphate 4-kinase activity
ATP binding
kinase activity
nucleotide binding
phosphatidylinositol kinase activity
phosphorylation
transferase activity

Displaying **all 4** entries
InterPro
Phosphatidylinositol-4-phosphate 4/5-kinase, C-terminal domain superfamily
Phosphatidylinositol-4-phosphate 4/5-kinase, core
Phosphatidylinositol-4-phosphate 5-kinase, N-terminal
Phosphatidylinositol-4/5-phosphate 5/4-kinase