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Guidelines

MIRAGE

delta like canonical Notch ligand 1

Summary

Gene Symbol

Dll1

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

84010

PubChem

84010

Alliance of Genome Resources

RGD:70949

Annotation

Keyword

Cell junction
Cell membrane
Developmental protein
Differentiation
Disulfide bond
EGF-like domain
Glycoprotein
Isopeptide bond
Notch signaling pathway
Phosphoprotein
Reference proteome
Repeat
Signal
Transmembrane helix
Ubl conjugation

Proteins

Displaying **all 3** entries
UniProt	Protein Name
P97677	Drosophila Delta homolog 1
G3V7W6
A6KB40

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of **110** in total

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GO Term	Evidence Code	PMID
cell fate determination	TAS	14743446
somitogenesis	ISS
somitogenesis	ISO
somite specification	ISO
heart looping	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cellular process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cell communication

cell-cell signaling

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Notch signaling pathway involved in arterial endothelial cell fate commitment

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

endothelial cell fate specification [inference]

blood vessel endothelial cell fate specification [inference]

endothelial tip cell fate specification

cell fate determination

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cell fate commitment

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

glial cell development [inference]

astrocyte development

multicellular organismal process [inference]

cell activation [inference]

cell activation involved in immune response [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

leukocyte activation [inference]

leukocyte activation involved in immune response [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte activation [inference]

lymphocyte activation involved in immune response [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell activation [inference]

B cell activation involved in immune response [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification [inference]

proximal/distal pattern formation

segmentation [inference]

somitogenesis

segment specification [inference]

somite specification

axis specification [inference]

left/right axis specification

specification of symmetry [inference]

determination of bilateral symmetry [inference]

determination of left/right symmetry

embryonic pattern specification [inference]

somite specification

stem cell population maintenance [inference]

neuronal stem cell population maintenance

organ growth

multicellular organismal-level homeostasis [inference]

energy homeostasis

developmental process [inference]

anatomical structure morphogenesis [inference]

tube morphogenesis [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

embryonic morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

tissue morphogenesis [inference]

morphogenesis of an epithelium [inference]

epithelial tube morphogenesis [inference]

embryonic heart tube morphogenesis [inference]

heart looping

retina morphogenesis in camera-type eye

anatomical structure arrangement [inference]

cerebellar Purkinje cell layer structural organization

anatomical structure formation involved in morphogenesis [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development [inference]

skin epidermis development

epithelium development [inference]

renal tubule development [inference]

nephron tubule development [inference]

kidney epithelium development [inference]

nephron epithelium development [inference]

nephron tubule development [inference]

skin epidermis development

spinal cord development

tube development [inference]

renal tubule development [inference]

nephron tubule development [inference]

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

glial cell development [inference]

astrocyte development

system development [inference]

nervous system development

cellular developmental process [inference]

cell fate specification [inference]

neuron fate specification

endothelial cell fate specification [inference]

blood vessel endothelial cell fate specification [inference]

endothelial tip cell fate specification

cell fate determination

cell differentiation [inference]

leukocyte differentiation [inference]

mononuclear cell differentiation [inference]

lymphocyte differentiation [inference]

B cell differentiation [inference]

mature B cell differentiation [inference]

mature B cell differentiation involved in immune response [inference]

marginal zone B cell differentiation

cell fate commitment

neuron fate commitment [inference]

inner ear receptor cell fate commitment [inference]

auditory receptor cell fate commitment

cell development [inference]

epithelial cell development [inference]

type B pancreatic cell development

glial cell development [inference]

astrocyte development

maintenance of cell number [inference]

stem cell population maintenance [inference]

neuronal stem cell population maintenance

growth [inference]

developmental growth [inference]

homeostatic process [inference]

multicellular organismal-level homeostasis [inference]

energy homeostasis

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

import into cell [inference]

endocytosis [inference]

receptor-mediated endocytosis [inference]

clathrin-dependent endocytosis

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation

regulation of signaling [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

signaling [inference]

cell-cell signaling

cell-cell signaling involved in cell fate commitment [inference]

lateral inhibition

regulation of localization [inference]

regulation of transport [inference]

positive regulation of transport [inference]

positive regulation of endocytosis

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of growth

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of growth [inference]

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of transport [inference]

positive regulation of endocytosis

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of biological process [inference]

negative regulation of signaling [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of glial cell apoptotic process

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of developmental process [inference]

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of response to stimulus [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of vascular endothelial growth factor receptor signaling pathway

regulation of cellular response to vascular endothelial growth factor stimulus [inference]

regulation of vascular endothelial growth factor signaling pathway

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of development, heterochronic [inference]

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

regulation of neuron differentiation [inference]

regulation of mechanoreceptor differentiation [inference]

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear receptor cell differentiation [inference]

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cell development [inference]

regulation of neurogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of epidermis development [inference]

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of muscle organ development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

regulation of developmental growth [inference]

regulation of skeletal muscle tissue growth

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

negative regulation of developmental process [inference]

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of epidermis development [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

positive regulation of developmental process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of developmental growth [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of muscle tissue development [inference]

regulation of striated muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of muscle tissue development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of embryonic development [inference]

inhibition of neuroepithelial cell differentiation

regulation of nervous system development [inference]

regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Notch signaling pathway involved in arterial endothelial cell fate commitment

regulation of cell communication [inference]

regulation of signal transduction [inference]

regulation of Notch signaling pathway [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of gene expression

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

regulation of cell adhesion

regulation of cell population proliferation [inference]

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

regulation of glial cell apoptotic process [inference]

negative regulation of glial cell apoptotic process

negative regulation of apoptotic process [inference]

negative regulation of glial cell apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of glial cell apoptotic process

regulation of cell differentiation [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of myoblast differentiation [inference]

negative regulation of myoblast differentiation

regulation of neuron differentiation [inference]

regulation of mechanoreceptor differentiation [inference]

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear receptor cell differentiation [inference]

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of timing of cell differentiation [inference]

inhibition of neuroepithelial cell differentiation

regulation of muscle cell differentiation [inference]

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of striated muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cell development [inference]

regulation of neurogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation

regulation of cardiocyte differentiation [inference]

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cardiac muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

positive regulation of cellular process [inference]

positive regulation of cell population proliferation

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of RNA metabolic process [inference]

positive regulation of RNA biosynthetic process [inference]

positive regulation of DNA-templated transcription [inference]

positive regulation of transcription by RNA polymerase II

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Notch signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

negative regulation of cellular process [inference]

negative regulation of cell population proliferation

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cell communication [inference]

negative regulation of signal transduction [inference]

negative regulation of Notch signaling pathway

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of glial cell apoptotic process

negative regulation of cell differentiation

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of neuron differentiation

negative regulation of mechanoreceptor differentiation [inference]

negative regulation of inner ear receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

negative regulation of muscle cell differentiation [inference]

negative regulation of striated muscle cell differentiation [inference]

negative regulation of cardiac muscle cell differentiation

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of cellular component organization [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

positive regulation of cellular component organization [inference]

positive regulation of endocytosis

regulation of cell division

regulation of vesicle-mediated transport [inference]

regulation of endocytosis [inference]

positive regulation of endocytosis

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

regulation of interleukin-10 production [inference]

negative regulation of interleukin-10 production

regulation of somitogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of muscle organ development [inference]

positive regulation of striated muscle tissue development [inference]

positive regulation of skeletal muscle tissue development [inference]

positive regulation of skeletal muscle tissue growth

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of interleukin-10 production

negative regulation of cardiocyte differentiation [inference]

negative regulation of cardiac muscle cell differentiation

regulation of multicellular organismal development [inference]

regulation of epithelial cell differentiation [inference]

negative regulation of epithelial cell differentiation

inhibition of neuroepithelial cell differentiation

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of epidermal cell differentiation [inference]

negative regulation of epidermal cell differentiation

negative regulation of inner ear auditory receptor cell differentiation

regulation of inner ear auditory receptor cell differentiation [inference]

negative regulation of inner ear auditory receptor cell differentiation

regulation of embryonic development [inference]

inhibition of neuroepithelial cell differentiation

regulation of nervous system development [inference]

regulation of neurogenesis

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of sprouting angiogenesis [inference]

positive regulation of sprouting angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis [inference]

positive regulation of sprouting angiogenesis

regulation of hemopoiesis [inference]

regulation of myeloid cell differentiation [inference]

negative regulation of myeloid cell differentiation

regulation of biological quality [inference]

regulation of blood pressure

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
plasma membrane	ISO
plasma membrane	TAS
plasma membrane	IBA
adherens junction	ISS
adherens junction	ISO

GO Hierarchy

cellular component

cellular anatomical structure [inference]

plasma membrane

plasma membrane region [inference]

apical plasma membrane

membrane microdomain [inference]

membrane raft

cell junction [inference]

anchoring junction [inference]

cell-cell junction [inference]

adherens junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying entries **1 - 5** of 10 in total

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GO Term	Evidence Code	PMID
Notch binding	ISO
Notch binding	TAS	14743446
Notch binding	IBA
Notch binding	IPI	10079256 11823422 28089369
Notch binding	IEA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

Notch binding

transcription factor binding [inference]

DNA-binding transcription factor binding [inference]

RNA polymerase II-specific DNA-binding transcription factor binding [inference]

Tat protein binding

scaffold protein binding

small molecule binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

molecular function regulator activity [inference]

signaling receptor regulator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

molecular function activator activity [inference]

signaling receptor activator activity [inference]

receptor ligand activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Delta-like protein

Functional Category

O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
Notch binding
calcium ion binding
cell communication
negative regulation of Notch signaling pathway

Displaying **all 8** entries
InterPro
Delta/Serrate/lag-2 (DSL) protein
EGF-like calcium-binding domain
EGF-like calcium-binding, conserved site
EGF-like domain
EGF-like, conserved site
EGF-type aspartate/asparagine hydroxylation site
Growth factor receptor cysteine-rich domain superfamily
Notch ligand, N-terminal domain

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: April 6, 2026