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Guidelines

MIRAGE

ubiquitin specific peptidase 8

Summary

Gene Symbol

Usp8

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

84092

PubChem

84092

Alliance of Genome Resources

MGI:1934029

Annotation

Keyword

3D-structure
Cell cycle
Cell membrane
Coiled coil
Cytoplasm
Endosome
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
SH3-binding
Thiol protease
Ubl conjugation
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q80U87	Deubiquitinating enzyme 8 Ubiquitin isopeptidase Y Ubiquitin thioesterase 8 Ubiquitin-specific-processing protease 8
A2AI52

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 20 in total

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GO Term	Evidence Code	PMID
mitotic cytokinesis	ISO
proteolysis	IEA
endosome organization	IMP	16771824
endosome organization	IBA
Ras protein signal transduction	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein removal [inference]

protein deubiquitination

cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

cell cycle process [inference]

cytokinesis [inference]

cytoskeleton-dependent cytokinesis [inference]

mitotic cytokinesis

mitotic cell cycle process [inference]

mitotic cytokinesis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vesicle organization [inference]

endosome organization

response to stimulus [inference]

response to endogenous stimulus [inference]

response to growth factor [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

response to nerve growth factor [inference]

cellular response to nerve growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to nerve growth factor stimulus

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of amyloid fibril formation [inference]

positive regulation of amyloid fibril formation

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of amyloid fibril formation [inference]

positive regulation of amyloid fibril formation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of protein catabolic process in the vacuole [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of lysosomal protein catabolic process [inference]

negative regulation of lysosomal protein catabolic process

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of amyloid fibril formation [inference]

positive regulation of amyloid fibril formation

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

regulation of localization [inference]

regulation of cellular localization [inference]

regulation of protein localization

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of amyloid fibril formation

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of protein catabolic process in the vacuole [inference]

negative regulation of lysosomal protein catabolic process

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction [inference]

small GTPase mediated signal transduction [inference]

Ras protein signal transduction

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of Wnt signaling pathway [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of canonical Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

regulation of trans-synaptic signaling [inference]

modulation of chemical synaptic transmission [inference]

postsynaptic modulation of chemical synaptic transmission [inference]

regulation of protein catabolic process at postsynapse, modulating synaptic transmission

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of Wnt signaling pathway [inference]

positive regulation of canonical Wnt signaling pathway

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

regulation of cellular component organization [inference]

positive regulation of cellular component organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

regulation of supramolecular fiber organization [inference]

positive regulation of supramolecular fiber organization [inference]

positive regulation of amyloid fibril formation

regulation of amyloid fibril formation [inference]

positive regulation of amyloid fibril formation

regulation of cellular localization [inference]

regulation of protein localization

regulation of biological quality [inference]

regulation of protein stability

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
acrosomal membrane	IDA	15342353
intracellular anatomical structure	IDA	11500497
nucleus	IEA
cytoplasm	ISO
early endosome	ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

endosome membrane

secretory granule membrane [inference]

acrosomal membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

midbody

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

neuron spine [inference]

dendritic spine

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

postsynaptic specialization [inference]

postsynaptic density

postsynapse [inference]

dendritic spine

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cysteine-type deubiquitinase activity	ISO
cysteine-type deubiquitinase activity	IDA	11500497 15342353 16120644 16771824
cysteine-type deubiquitinase activity	IBA
protein binding	IPI	10982817 15314180 15342353 16120644 16771824
SH3 domain binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

cysteine-type peptidase activity [inference]

cysteine-type deubiquitinase activity

ubiquitin-like protein peptidase activity [inference]

deubiquitinase activity [inference]

binding [inference]

protein binding

protein domain specific binding [inference]

SH3 domain binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ubiquitin carboxyl-terminal hydrolase

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Papain-like cysteine peptidase superfamily
Peptidase C19, ubiquitin carboxyl-terminal hydrolase
Ubiquitin specific protease domain
Ubiquitin specific protease, conserved site

Ortholog

Displaying entries **1 - 10** of 90 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	9101	Xenbase:XB-GENE-969023	HUMAN23060
Xenopus tropicalis	84092	Xenbase:XB-GENE-969023
Rattus norvegicus	296121		RATNO27960
Pan troglodytes	453931		PANTR10306
Canis lupus familiaris	478299		CANLF12508
Danio rerio	565434		DANRE13649
Macaca mulatta	715523		MACMU42705
Xenopus tropicalis	856887	Xenbase:XB-GENE-969023
Monodelphis domestica	100026038		MONDO03935
Equus caballus	100055443		HORSE16494

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Last updated: August 4, 2025